Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00031 0.098 15.2 2.9 1 23 117 139 117 139 0.99

2 6 0.00018 0.057 16.0 5.1 1 23 145 167 145 167 0.98

3 6 1.2e-06 0.00038 22.8 0.5 1 23 173 195 173 195 0.99

4 6 2.8e-05 0.009 18.5 0.3 1 23 201 224 201 224 0.97

5 6 9.8e-06 0.0031 19.9 1.5 1 23 230 252 230 252 0.98

6 6 2.3 7.3e+02 3.0 0.3 3 12 320 329 315 331 0.85

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00031	0.098	15.2	2.9	1	23	117	139	117	139	0.99
2	6	0.00018	0.057	16.0	5.1	1	23	145	167	145	167	0.98
3	6	1.2e-06	0.00038	22.8	0.5	1	23	173	195	173	195	0.99
4	6	2.8e-05	0.009	18.5	0.3	1	23	201	224	201	224	0.97
5	6	9.8e-06	0.0031	19.9	1.5	1	23	230	252	230	252	0.98
6	6	2.3	7.3e+02	3.0	0.3	3	12	320	329	315	331	0.85

Coding Sequence: ATGGATTGCAGCGAGTCAAATATGTCTGACGGGAAAGAACTCGGTTCTAATGTTGTTTTGAAACATGAACGAGTCGCAGATGCTGAAGTAATGGAGCCATTCACCATTAAGAGTGAGGAAACGTATGATTCTGAAGAAGAGCCTCAACCCCAAGATTCTGACATCGATCAGAATCACCACACAACCAAGGCCAACGAAGTTCACGATGTTGAATTACAAATTGGGGAACCTGTGATTCTGAAGGAGGAACCCATCATGGACAGCGGTTACTCGATGGATTGGATGGGGGGCCCATTGCTTAAGCCTGACCCTGATGAAGCTCCATCCACTAGCTCAGGTGATAAGGGATACACCTGTCAGTTCTGCGACTACCAAACCAAAACTAAATCAGGAATGACCAAACATGCCAAAACACACACAGGTGATAAGCGATACACCTGCCAGTTCTGTGACTACCAAACCACCACTAAGTCACATTTGACCCAGCATGTCTATACACACACAGGGGAGAAACCATTCACTTGTGAAATCTGCAAACTCAGTCTCAGTTATAAATCTGATTTGGTTGTCCACATGAGAACTCATACAGGGGAGAAACCTTTCTCGTGTGGTGATTGCGATTACATGGCCATTACAAAGTCAAACCTCATCAGCCACCAAATGAGGCAGCACAACGGCGAAAAGCCATACAAATGCAGTGACTGTGACTATGCCACAGCCCGGAAGTGGCATCTGCTGAGGCACGCGAAATCACATGAAGGTACATTTTCTACTCTTCATTCTCATGTTGCTAGCCCGTATATACATAATTTTTGTAAAATAAGTGCCTGCATCCTCAGAGTGTACAGTGCTCAAAGAGGGTTCTTCTTCTCCAACGTTGGCTGGCTGATGACCAAGAAACATCCTGACGTCATAGAGAAGGGAAAGCAAATTGTCATATCCGACCTTCAAAAACACTGTGAAGACTGTGTGAAGATGTTTCAAAAGAAGGACATCCCCGAGTCACTCGTCCACTCATCACCCCAAAGGAAACTGGACGAATTGAGAAGTTCATTGCTACGATTTGCAAAGCTGTTTCCCAAGCCGTAA
Protein Sequence: MDCSESNMSDGKELGSNVVLKHERVADAEVMEPFTIKSEETYDSEEEPQPQDSDIDQNHHTTKANEVHDVELQIGEPVILKEEPIMDSGYSMDWMGGPLLKPDPDEAPSTSSGDKGYTCQFCDYQTKTKSGMTKHAKTHTGDKRYTCQFCDYQTTTKSHLTQHVYTHTGEKPFTCEICKLSLSYKSDLVVHMRTHTGEKPFSCGDCDYMAITKSNLISHQMRQHNGEKPYKCSDCDYATARKWHLLRHAKSHEGTFSTLHSHVASPYIHNFCKISACILRVYSAQRGFFFSNVGWLMTKKHPDVIEKGKQIVISDLQKHCEDCVKMFQKKDIPESLVHSSPQRKLDELRSSLLRFAKLFPKP

Sequence clustering based on sequence similarity using MMseqs2