Basic Information

Gene Symbol
-
Assembly
GCA_954871275.1
Location
OX940979.1:43569528-43576614[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.00072 0.23 14.1 0.8 1 19 257 275 257 279 0.89
2 12 0.0071 2.2 10.9 0.4 2 23 282 304 281 304 0.96
3 12 2e-06 0.00065 22.1 1.2 2 23 372 393 371 393 0.97
4 12 2.7e-05 0.0086 18.6 0.6 1 23 399 421 399 421 0.97
5 12 0.00025 0.078 15.5 2.4 1 23 427 449 427 449 0.98
6 12 3.3e-05 0.01 18.3 1.8 1 23 455 477 455 477 0.98
7 12 0.00025 0.079 15.5 3.5 1 23 483 505 483 505 0.99
8 12 2.8e-06 0.0009 21.6 0.4 1 23 513 535 513 535 0.98
9 12 0.0016 0.51 13.0 0.2 1 23 541 563 541 563 0.96
10 12 2.7e-05 0.0084 18.6 1.2 1 23 569 591 569 591 0.98
11 12 0.00015 0.046 16.2 0.2 1 23 597 619 597 619 0.98
12 12 1.5e-05 0.0049 19.3 2.4 1 23 625 647 625 647 0.98

Sequence Information

Coding Sequence
ATGGCATCGTCGATGGACCCTCTGGTGGAATTCGGCGAGCTTTGCCGTCTCTGCGGATCGAAAACAACAATGTTGATGGGTCTTCACATTTTCGAAAGGGAAGGAAGCATTCGAGAGATATTCAAGAAGATCAAAGCCTGCCTTCCCATTCAAGTCACCAGTGACGACAAGCTGCCGAAAATGGTGTGTGAAGAGTGCGTCTACAAGTTGGATGCACTGTACGAGTTCAGAGAGAAAAGTGTGAAGACGGAGTACTTGCTCAATAGTATGATGAAGGGCCTTATCGCTAGCACGCCTTCCAACCAGCATTACACTCCACCTCCTAGCCTCCCTATTGAGACGCCGACCAGTCTTCCGCTGTGCAGCCCTACTATGGTCGATGCTATGCATTTGAGTGCGCAGGTCGAAGTTCATATAACAGACAACGCTGACCACCTGGAGTCCATCATCATTGGAATGCCAATGACTGAAAGTGAGCAAATCAAGCACGAACCAGGTGTAGCCGTACAAAAGAGGAAAAAAGAAAGCTTGGTAGTTCACAACATGGAAGGGAACACAAATGATTCCATGGTGTCTGTCACGGATGTGGATCATAGTACTGACAATTGTACCATCACAGAACACATTGTCAACAATATTCAAGTTGCCGATATGAGGTCTCTTCAGGCTATCAGTAGTACCACTCAGGGCATTGCCAACTTGAAGACTACCACTGATGATCAGGGGACCAGACACTTCATCATGGCCACCCATACCGAACAACCATGGTTCTTTTGTGATATCTGCGGCAAGCCTTTTGGTGACAGTAACGAGTTCCAAGCGCATTGTGAAATTCATTGGAAGAAGTGTCAGGTTTGCGGCGTGACTTGCGCAAACGATGAGGCGCTTATGCTCCATTTGAGGGAATCTCACAACACCTCGCTTCAGCAGCTTCAGTCTGCTCATGCTATTCAAGAGCAGCCGTTGTCATCCCAGCCGGACACTGTGTCTGTACAACAGCAATCTTCGCCGATAGTTATGAGTGATTCTGATGAGCCCAATACCACAGGAATTCCTGATGAAAAGGTTATAAAAACGGAAGCTAAAAAAGAAGGTTCTTCCGATGGAGCGAAATCCTGTTCTGAATGTGGTAAAGAGTACAAAACGAACTACAAGCTTGCGGAGCATATGAGGAAACACACTGGTGAAAAACCCTACAAGTGCTCAATGTGTGAAAAAACATTCAGATCCAAAATCGGCCTTGCTCAGCACGAAGCGAGACACACTGGGCATTATGATTACAGCTGCAGCACTTGCGGGAAAGGGTTTCAGTGCAAGTCCTACTTGATTGTTCATCAAAGGGTCCATAGTGACCTCAAGCCGTACCCTTGTGACACTTGTAGTCGTAATTTCAAAACCAAGCAAAGCTTGCTGGACCACCAGAACCGCCATTTGGGCGTCAAACCATATCAGTGTCAAACTTGTGGCCGGAGCTTCATCACAAAAGGCCTCTGCAAGTCTCATCAGAAGGTCCACTCGGGCACGGACAACCGGCAGTTCCCCTGTTCTGTGTGCAGCAAGCTGTTCGTGAGCAAGTCCTACCTCGCGACTCACATGAGGATTCATACCGGAGAAAAACCGTTCATGTGCGAAGTGTGCGGTAAAGGGTTCTTGACGCGCGTCGACCTGAAGATCCATTCCACGATGCACACTGGCGAAAAGAGTTTCGTCTGCGAGGTCTGCGGGAAGGCGTTTGCTCGCCGGGACGCTCTCAGGTGCCACAAAAGAAGCCATACTGGTGAACGCCCTTACAAATGTGATATTTGCGGCCAAGGATTCACCCAGTTCTCTCCAATGGCGATCCACAAACGCCTCCACACCGGGGAAAGGCCATACTCCTGTGATATTTGCAGTAAGACTTTCGTTTCCCGCTCCACAATGATGTCTCACAGGAAGAAACACGCCGTTTCTTGA
Protein Sequence
MASSMDPLVEFGELCRLCGSKTTMLMGLHIFEREGSIREIFKKIKACLPIQVTSDDKLPKMVCEECVYKLDALYEFREKSVKTEYLLNSMMKGLIASTPSNQHYTPPPSLPIETPTSLPLCSPTMVDAMHLSAQVEVHITDNADHLESIIIGMPMTESEQIKHEPGVAVQKRKKESLVVHNMEGNTNDSMVSVTDVDHSTDNCTITEHIVNNIQVADMRSLQAISSTTQGIANLKTTTDDQGTRHFIMATHTEQPWFFCDICGKPFGDSNEFQAHCEIHWKKCQVCGVTCANDEALMLHLRESHNTSLQQLQSAHAIQEQPLSSQPDTVSVQQQSSPIVMSDSDEPNTTGIPDEKVIKTEAKKEGSSDGAKSCSECGKEYKTNYKLAEHMRKHTGEKPYKCSMCEKTFRSKIGLAQHEARHTGHYDYSCSTCGKGFQCKSYLIVHQRVHSDLKPYPCDTCSRNFKTKQSLLDHQNRHLGVKPYQCQTCGRSFITKGLCKSHQKVHSGTDNRQFPCSVCSKLFVSKSYLATHMRIHTGEKPFMCEVCGKGFLTRVDLKIHSTMHTGEKSFVCEVCGKAFARRDALRCHKRSHTGERPYKCDICGQGFTQFSPMAIHKRLHTGERPYSCDICSKTFVSRSTMMSHRKKHAVS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01365787;
90% Identity
iTF_01365787;
80% Identity
-