Basic Information

Insect: Leptidea sinapis
Gene Symbol: Smg1
Assembly: GCA_905404315.1
Location: FR990154.1:15424403-15442325[-]

Transcription Factor Domain

TF Family: MH1
Domain: MH1 domain
PFAM: PF03165
TF Group: Unclassified Structure
Description: The MH1 (MAD homology 1) domain is found at the amino terminus of MAD related proteins such as Smads. This domain is separated from the MH2 domain by a non-conserved linker region. The crystal structure of the MH1 domain shows that a highly conserved 11 residue beta hairpin is used to bind the DNA consensus sequence GNCN in the major groove, shown to be vital for the transcriptional activation of target genes. Not all examples of MH1 can bind to DNA however. Smad2 cannot bind DNA and has a large insertion within the hairpin that presumably abolishes DNA binding. A basic helix (H2) in MH1 with the nuclear localisation signal KKLKK has been shown to be essential for Smad3 nuclear import. Smads also use the MH1 domain to interact with transcription factors such as Jun, TFE3, Sp1, and Runx [2, 1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 20 0.55 3.7e+03 -0.7 0.0 20 71 251 299 248 309 0.80

2 20 0.0013 9.1 7.7 0.4 37 95 713 774 684 780 0.76

3 20 0.0055 37 5.7 0.0 59 95 781 820 774 827 0.83

4 20 0.0015 10 7.5 0.3 36 95 806 866 805 873 0.77

5 20 0.0054 36 5.8 0.0 59 95 873 912 866 920 0.83

6 20 0.0057 39 5.7 0.0 59 95 919 958 912 964 0.83

7 20 0.0057 38 5.7 0.0 59 95 965 1004 958 1010 0.83

8 20 0.0061 41 5.6 0.0 59 95 1011 1050 1004 1053 0.82

9 20 0.001 6.7 8.1 0.3 35 95 1035 1096 1034 1102 0.79

10 20 0.0011 7.3 8.0 0.3 35 95 1081 1142 1080 1145 0.79

11 20 0.0055 37 5.7 0.0 59 95 1149 1188 1142 1195 0.83

12 20 0.0054 36 5.8 0.0 59 95 1195 1234 1188 1242 0.83

13 20 0.0063 42 5.5 0.0 60 95 1242 1280 1235 1286 0.83

14 20 0.00092 6.2 8.2 0.2 35 95 1265 1326 1264 1334 0.79

15 20 0.27 1.8e+03 0.3 0.1 59 95 1333 1367 1326 1373 0.79

16 20 0.0023 16 6.9 0.4 45 95 1360 1413 1336 1419 0.78

17 20 0.0085 57 5.1 0.3 73 95 1391 1413 1375 1460 0.53

18 20 0.0029 20 6.6 0.3 51 95 1453 1500 1439 1506 0.78

19 20 0.0064 43 5.5 0.0 59 94 1507 1545 1500 1548 0.82

20 20 0.001 6.7 8.1 0.3 35 95 1531 1592 1530 1598 0.79

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	20	0.55	3.7e+03	-0.7	0.0	20	71	251	299	248	309	0.80
2	20	0.0013	9.1	7.7	0.4	37	95	713	774	684	780	0.76
3	20	0.0055	37	5.7	0.0	59	95	781	820	774	827	0.83
4	20	0.0015	10	7.5	0.3	36	95	806	866	805	873	0.77
5	20	0.0054	36	5.8	0.0	59	95	873	912	866	920	0.83
6	20	0.0057	39	5.7	0.0	59	95	919	958	912	964	0.83
7	20	0.0057	38	5.7	0.0	59	95	965	1004	958	1010	0.83
8	20	0.0061	41	5.6	0.0	59	95	1011	1050	1004	1053	0.82
9	20	0.001	6.7	8.1	0.3	35	95	1035	1096	1034	1102	0.79
10	20	0.0011	7.3	8.0	0.3	35	95	1081	1142	1080	1145	0.79
11	20	0.0055	37	5.7	0.0	59	95	1149	1188	1142	1195	0.83
12	20	0.0054	36	5.8	0.0	59	95	1195	1234	1188	1242	0.83
13	20	0.0063	42	5.5	0.0	60	95	1242	1280	1235	1286	0.83
14	20	0.00092	6.2	8.2	0.2	35	95	1265	1326	1264	1334	0.79
15	20	0.27	1.8e+03	0.3	0.1	59	95	1333	1367	1326	1373	0.79
16	20	0.0023	16	6.9	0.4	45	95	1360	1413	1336	1419	0.78
17	20	0.0085	57	5.1	0.3	73	95	1391	1413	1375	1460	0.53
18	20	0.0029	20	6.6	0.3	51	95	1453	1500	1439	1506	0.78
19	20	0.0064	43	5.5	0.0	59	94	1507	1545	1500	1548	0.82
20	20	0.001	6.7	8.1	0.3	35	95	1531	1592	1530	1598	0.79

Sequence Information

Coding Sequence: ATGCGACGCGGGCGCGAGACGCTGCTCACGCTGCTGGAGGCGTTTGTGTACGACCCGCTGGTGGAGTGGGGCGGGGGCCGGCGGCGGCGGGGGGAGAGGCACGTGCGAGCCGCGCGCGCCATGTTGGCCGTGCGAGTGCACGAGCTGAAGTACAGCGTCAACCACCTCGTCGAACAACTTTTGACATTATTACCCGAAGTAAAGAAGTGCGCAGACAAGTGGCTCGAAGAGAATGAAGAACTGAATGCTATTCAATCCAAGTTACAGCTGTGTCACCAACAAATGGTTCTGATCAAAGAAATCGAGGCATACGGAAGTAACCTGAGTAACCATCCATTACACGCTATATCTCAGAAGTATGCCTCCTACAAGCAAGCGAAAAACGCGGTCGAAGACTCCATGAAAGCTTTAGTTAAAATCCTGAACGACTTTGACACCCAAATAGAAAACTTTGCCTCAACCAATGAAGTGCTTAACGGTCCTCAATTAATGGCATGGGTACAAGAGTATAGTGGCCCCAACGAAGACGAACAATTGCCTATTTTTGAACATATAAAAGAATTTCTAACCAACGCGGGCCAAGGAACTATGTTGACACAATGCGAACAAGCCGAAGCTGAATTAAATCAGTGCATGCAGCAAACGAATGTACTCCTTCGTTCTTGTATTGAGCTACTGTCGCAGTATGTAGCCGTATCACAATATTATCCTCGGAGCCAAACAGAATACCATCGCATAGTGTTGTTCCGTGAATACCTCGCGAAGGCATTAGAAAGTAAATCACCCGAGGTCTGCCGCGAGGTTGCTAATCAAGTCACGGCGCTCGTGAACGCTGAGAGTAGCGCGGATCCACAACAAGTCATCGCCTACAATTACCGCCTTCAGCAATTGAACGGTGATTCCAACACCCTGGTCAATAAGTGCTTGGACCGGCTGCAACTAGAAGGTGGGCCTGATGCTATTACAAAAGCCCAAGAATCTTACAAAGACGTGAAAACTAATATAAGCAATTGGGTCCGGGCCGAAGAAGGTGCTGCAGCTGCGCTGGAAAGTGTCTCAATTGGAATGCTGTGCAATTTGAACAGGCGGTATTTAATGTTGGAGAATGGAGCTCAGAGTGCGGGTGATTGTCTTGTGGATCTGACATCCAGAGAGGGGGGATGGTTCCTGGACGACATGAGCGCTTTGTCCATGCAGACTGTCGAGTTACTCTCACTCTTGCCGCTGCAATCGGCGGCGGTTGAAGACGCTTCGATGCCCGTTGCTGTTGAATGTGTGAGGAACGCGAACTTGTTGCTGGCTGATCTGGTGCAATTGAATTACAATTTCAGCACCATTATACTACCTGAAGCCCTGAAGAAGGTGCACTCGGAAGATCCCTCCACGCTGCAAATCATCAATGAGTTGAATGCTGTCATTTTGAACTCTCCGGCACCATTGAACGAGATACTCGCACAGTTGGAGGTGCATTTCAGATACTTGGTAATGGAAATGGAGTCCCCTGCCAGCGGTGCTCCCCTGTGGGCGGCAGCTCTGCGCGCCAGATACGAAGCTCTCCTTTCCCCACCGAACGAGGGCGAGGCCCAATCAGGTGGCAGGATGCTGCTGATGGGCTTTAACGGACTGTTTGCGGCCGTTGAGCTGAGGGCTCGCGAGCTAGCGGACCATCTCAACTCGCCCATACCGGCCGCCTGGAGGAAGATCGATCACGTTAATGATGCGCTACATATGTCCGCAGCGATGCAAAGTCCCGCTCTTCGCGGCGTACTAGAAGACATATTCCTGGTCCGTCGTATTCAGACTGTGGGGGAAGTGTTTGCAATGTGCGCCCAGCTCAGTTGTGCTTTCCGCGGCACCGGGCCCACTGTGCTGTACGACGATGCTGCACTCTGCAAGCCGGTTCGAAGGTTCATAGCGGAGTACGTGTCGCGCTGCCTGCTGGGCGTGCACTCCAAGGCTCTGGCATCCGTGCTGTGTCTGCTGCTGCGGCGCGCACGCCTCGACCTTCACGCGGAGGTGGAACAAAAGGAGATCGGTGCGTCGTGGAGCGTGTCGCTCGAGTCGCTGTGCGAGAAGGTGTGCGCGGGCGCGAGCGGGGAGCGGGCCGTGGAGCGGGCGGCGTCGCTGGCGGGCAGCCTGTGTGCGAGCCGCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTGTGTGCGAGCCGCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTGTGTGCGAGCCGCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGGTACGCGGTCTATCTAGGTGTGTGCGAGCCGCGCGCGCCGACCGCGCCGCCGTGTGCGTGCGGGCGCTGGAGCGGGCGCGGGCCGCCGCGCGCATGCACCGACTGAGGGCACTGGCGCACGCACACCTGCACGCTGAGATACTGAACAGTAACCAAGAGTGGAGCGGGCAGTTGGCGCGTCGAGCTCGCGAGCTGAGCGCGGCCCTCGAGCGGCTGCAGGCCGGTCGCACCAAGGCGCATGGACTGCTGCAGGCCGCGCGACAGAGGTGGGGCGCGATACCGACTCAATCAGCTCTCAGGAgccacaataatataatatacaaataa
Protein Sequence: MRRGRETLLTLLEAFVYDPLVEWGGGRRRRGERHVRAARAMLAVRVHELKYSVNHLVEQLLTLLPEVKKCADKWLEENEELNAIQSKLQLCHQQMVLIKEIEAYGSNLSNHPLHAISQKYASYKQAKNAVEDSMKALVKILNDFDTQIENFASTNEVLNGPQLMAWVQEYSGPNEDEQLPIFEHIKEFLTNAGQGTMLTQCEQAEAELNQCMQQTNVLLRSCIELLSQYVAVSQYYPRSQTEYHRIVLFREYLAKALESKSPEVCREVANQVTALVNAESSADPQQVIAYNYRLQQLNGDSNTLVNKCLDRLQLEGGPDAITKAQESYKDVKTNISNWVRAEEGAAAALESVSIGMLCNLNRRYLMLENGAQSAGDCLVDLTSREGGWFLDDMSALSMQTVELLSLLPLQSAAVEDASMPVAVECVRNANLLLADLVQLNYNFSTIILPEALKKVHSEDPSTLQIINELNAVILNSPAPLNEILAQLEVHFRYLVMEMESPASGAPLWAAALRARYEALLSPPNEGEAQSGGRMLLMGFNGLFAAVELRARELADHLNSPIPAAWRKIDHVNDALHMSAAMQSPALRGVLEDIFLVRRIQTVGEVFAMCAQLSCAFRGTGPTVLYDDAALCKPVRRFIAEYVSRCLLGVHSKALASVLCLLLRRARLDLHAEVEQKEIGASWSVSLESLCEKVCAGASGERAVERAASLAGSLCASRARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVCASRARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVCASRARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEVRGLSRCVRAARADRAAVCVRALERARAAARMHRLRALAHAHLHAEILNSNQEWSGQLARRARELSAALERLQAGRTKAHGLLQAARQRWGAIPTQSALRSHNNIIYK*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -