Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00065 0.081 14.5 2.4 3 23 136 157 135 157 0.96

2 6 0.00018 0.023 16.2 0.5 2 22 171 191 170 195 0.92

3 6 4.1e-07 5.1e-05 24.6 0.2 2 23 204 226 203 226 0.95

4 6 0.0015 0.19 13.3 2.8 1 23 232 255 232 255 0.94

5 6 4.5e-05 0.0057 18.1 1.9 3 23 266 286 265 286 0.98

6 6 0.00058 0.072 14.7 2.3 1 23 292 315 292 315 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00065	0.081	14.5	2.4	3	23	136	157	135	157	0.96
2	6	0.00018	0.023	16.2	0.5	2	22	171	191	170	195	0.92
3	6	4.1e-07	5.1e-05	24.6	0.2	2	23	204	226	203	226	0.95
4	6	0.0015	0.19	13.3	2.8	1	23	232	255	232	255	0.94
5	6	4.5e-05	0.0057	18.1	1.9	3	23	266	286	265	286	0.98
6	6	0.00058	0.072	14.7	2.3	1	23	292	315	292	315	0.98

Coding Sequence: atgGTCGCGCCTAAGGAAGAGGAAGACAGACATAGACGAGACATACTATTAGGTAAGGctgttataactttaaaagatttagagGGTAAAGAGGACATACTGGACGGGGAGGAAATAACCCCGGAAATGAGAGAGGCGTTACATAACTCTGTAGTTCCTGAATTACCAAAGAAACTCTTAAGAAAACCAGTAGAGAGGTATGGAGTTTCAAATCTCAGCATTACTGACAAGCAGAAGTACTTGGATGGTGAAAAAACATATGAGGAGGTGATAAAAGAGACCGATAAAGATATGTGGGAACACGCAATGGAACAGGAGCTCAAGGCTTTTGAAGAATACCAGGCTTGGGAAATAGTGGAAAGAAAGCAGAGAGTTCGGTGCAAAAAAACTCATCTACCCCCATTTTGCAACGAGTGTAACCGCCAATTCCCGAAGTACCACTCGCTGGAGGTTCACTACAGGAATTACCACCCGGAGCTGATCTACAAGAGTGTTCAGCCGGACCAGTCGTACTGCGTGGAGTGCAACAGACAATTCCGGAGTCAGTACCTCTACAAGCGACACCTGAGCACCGCCATAGCGCACGTGCAGAAGAAACCCATCAAGGTTCCTTGCCCCGACTGCGGGAAGGTGTTCTCTCGAAAAGCATATATGAAGAACCACTACAAACTGGTGCACGTTAGATCCTCGTCACACTACTGCGAAATATGTAATAAGCAATTCGTAAGCGGGTTTTCTTTGCGAACTCACACGAAATTTGTGCATCAAAAGTCTGCGCGACCCAAGGATAAGATTTGCGATGTTTGCGGCCGGGGTTTTCATACAAACCGGACACTTATAAACCACAAGCGAACACATACGGGTGAAAGGCCATACAAGTGCACGTACTGTCCCGCCGCGTTCGCGCAGTGCTATGCCAGGAAAACACACGAGAGGACACAACACAAGAATTTCACCGATAATTTCATTCTACCcacataa
Protein Sequence: MVAPKEEEDRHRRDILLGKAVITLKDLEGKEDILDGEEITPEMREALHNSVVPELPKKLLRKPVERYGVSNLSITDKQKYLDGEKTYEEVIKETDKDMWEHAMEQELKAFEEYQAWEIVERKQRVRCKKTHLPPFCNECNRQFPKYHSLEVHYRNYHPELIYKSVQPDQSYCVECNRQFRSQYLYKRHLSTAIAHVQKKPIKVPCPDCGKVFSRKAYMKNHYKLVHVRSSSHYCEICNKQFVSGFSLRTHTKFVHQKSARPKDKICDVCGRGFHTNRTLINHKRTHTGERPYKCTYCPAAFAQCYARKTHERTQHKNFTDNFILPT

Sequence clustering based on sequence similarity using MMseqs2