Basic Information

Gene Symbol
-
Assembly
GCA_949128165.1
Location
OX421902.1:2582102-2591220[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 21 0.0057 0.5 12.2 0.5 1 23 51 74 51 74 0.93
2 21 0.0094 0.83 11.5 1.1 3 23 106 124 104 124 0.96
3 21 0.00041 0.036 15.8 0.8 1 23 130 152 130 152 0.98
4 21 0.0049 0.43 12.4 1.0 2 23 159 180 158 180 0.97
5 21 3.3 2.9e+02 3.5 0.4 8 23 185 200 184 200 0.92
6 21 0.0049 0.43 12.4 1.0 2 23 207 228 206 228 0.97
7 21 3.3 2.9e+02 3.5 0.4 8 23 311 326 310 326 0.92
8 21 0.0049 0.43 12.4 1.0 2 23 333 354 332 354 0.97
9 21 3.3 2.9e+02 3.5 0.4 8 23 437 452 436 452 0.92
10 21 0.0049 0.43 12.4 1.0 2 23 459 480 458 480 0.97
11 21 3.3 2.9e+02 3.5 0.4 8 23 563 578 562 578 0.92
12 21 0.0049 0.43 12.4 1.0 2 23 585 606 584 606 0.97
13 21 3.3 2.9e+02 3.5 0.4 8 23 611 626 610 626 0.92
14 21 0.0049 0.43 12.4 1.0 2 23 633 654 632 654 0.97
15 21 3.3 2.9e+02 3.5 0.4 8 23 737 752 736 752 0.92
16 21 0.0049 0.43 12.4 1.0 2 23 759 780 758 780 0.97
17 21 3.3 2.9e+02 3.5 0.4 8 23 785 800 784 800 0.92
18 21 0.0049 0.43 12.4 1.0 2 23 807 828 806 828 0.97
19 21 3.3 2.9e+02 3.5 0.4 8 23 911 926 910 926 0.92
20 21 0.0049 0.43 12.4 1.0 2 23 933 954 932 954 0.97
21 21 3.1e-06 0.00027 22.5 0.9 1 23 960 982 960 982 0.98

Sequence Information

Coding Sequence
ATGCAATCGAACATCCTGTACGCCGCCGAGGTTGTAGACATTTTCTGCCTGTACGCAAATTGGTTTTTGGTAAGCAGGTTGTTCGATTCCAGGTTCAATAATAAAGCGAAACTCAAACTACACGTGCTTGGGCACAGCGACGCGAAGCCCCACGTCTGCGACCTGTGTGGGTACAGCAGCAAATACGCCTCCGGGCTCACGGCCCACAACATTAGGAGGCACGCGCCGACCAAATGCATTTGCAAGCTTTGCGGCAACGCGTTCTTAGACGCCGAGAAAATGGCGAAGCACTCCTGTACTGACACCAGCCAGATATGTCCCGTTTGTGGCAAGAGCGTGCGGCGAGGGCTCCACCGGCACATGCGCACGCACACGTCGGAGCGTCACTTCAAGTGCGAGCGCTGCCCCGCCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGTGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGTGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGTGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGTGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGTGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGTGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGAGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGTGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGTGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGTGCAGGCCCACAGACCACGTACAAGAGCCGCTCCGCCCTGAACGAGCACCGCGACAAGCACGACAACAACCCGCGGCAGGAGTGCGAGTACTGCCACGCGCGGTTCTACTCCGGCTCCGTGCTCATCAAGCACCGCCGCGTGCACACCGGTGAGAAACCATACGCGTGCACCAAGTGCGACATGCGGTTCACCGGCAACTACAACCTGAAGGTGCACATGAAGGTGCACGGCGAGAACCTCGTCAGCAAGAGGGGCCAGGAGCAGGGCGACGAGTAG
Protein Sequence
MQSNILYAAEVVDIFCLYANWFLVSRLFDSRFNNKAKLKLHVLGHSDAKPHVCDLCGYSSKYASGLTAHNIRRHAPTKCICKLCGNAFLDAEKMAKHSCTDTSQICPVCGKSVRRGLHRHMRTHTSERHFKCERCPATYKSRSALNEHRDKHDNNPRQECEYCHARFYSGSVLIKHRRVHTGPQTTYKSRSALNEHRDKHDNNPRQECEYCHARFYSGSVLIKHRRVHTGECRPTDHVQEPLRPERAPRQARQQPAAGVRVLPRAVLLRLRAHQAPPRAHRSASTATRGSTPAPCSSSTAACTPVSAGPQTTYKSRSALNEHRDKHDNNPRQECEYCHARFYSGSVLIKHRRVHTGECRPTDHVQEPLRPERAPRQARQQPAAGVRVLPRAVLLRLRAHQAPPRAHRSASTATRGSTPAPCSSSTAACTPVSAGPQTTYKSRSALNEHRDKHDNNPRQECEYCHARFYSGSVLIKHRRVHTGECRPTDHVQEPLRPERAPRQARQQPAAGVRVLPRAVLLRLRAHQAPPRAHRSASTATRGSTPAPCSSSTAACTPVSAGPQTTYKSRSALNEHRDKHDNNPRQECEYCHARFYSGSVLIKHRRVHTGPQTTYKSRSALNEHRDKHDNNPRQECEYCHARFYSGSVLIKHRRVHTGESRPTDHVQEPLRPERAPRQARQQPAAGVRVLPRAVLLRLRAHQAPPRAHRSASTATRGSTPAPCSSSTAACTPVSAGPQTTYKSRSALNEHRDKHDNNPRQECEYCHARFYSGSVLIKHRRVHTGPQTTYKSRSALNEHRDKHDNNPRQECEYCHARFYSGSVLIKHRRVHTGECRPTDHVQEPLRPERAPRQARQQPAAGVRVLPRAVLLRLRAHQAPPRAHRSASTATRGSTPAPCSSSTAACTPVSAGPQTTYKSRSALNEHRDKHDNNPRQECEYCHARFYSGSVLIKHRRVHTGEKPYACTKCDMRFTGNYNLKVHMKVHGENLVSKRGQEQGDE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-