Basic Information

Gene Symbol
ZFX
Assembly
GCA_949152495.1
Location
OX424454.1:862290-867562[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 2 3.1e+02 3.2 0.1 3 23 15 35 14 35 0.94
2 15 1.5 2.3e+02 3.7 3.8 1 23 972 995 972 995 0.81
3 15 0.00066 0.1 14.2 1.9 2 23 1092 1114 1091 1114 0.96
4 15 0.013 2 10.1 0.1 2 23 1127 1148 1127 1148 0.98
5 15 2.2e-05 0.0034 18.9 2.3 2 23 1151 1172 1150 1172 0.97
6 15 0.015 2.4 9.9 0.3 1 23 1178 1200 1178 1200 0.95
7 15 4.4e-05 0.0067 17.9 4.4 2 23 1207 1228 1206 1229 0.95
8 15 0.14 21 6.9 3.7 5 23 1242 1260 1241 1260 0.97
9 15 2.7e-05 0.0042 18.6 1.5 3 23 1267 1288 1266 1288 0.97
10 15 0.013 1.9 10.2 0.3 2 23 1304 1324 1303 1324 0.97
11 15 8.3e-05 0.013 17.1 0.7 1 20 1330 1349 1330 1352 0.92
12 15 0.0001 0.016 16.8 2.7 1 23 1360 1382 1360 1382 0.99
13 15 0.0029 0.44 12.2 3.2 1 23 1388 1410 1388 1410 0.97
14 15 5.2e-06 0.0008 20.8 3.9 1 23 1416 1438 1416 1438 0.99
15 15 0.0018 0.28 12.8 6.3 1 23 1444 1466 1444 1467 0.96

Sequence Information

Coding Sequence
ATGGAGCTCAGCGGTACGGGAACACCCGTCGGGGCCGTGGCCTGTCCCGTGTGTACCTTGTACCTGCGCGAGGGTATCAGTCTGCAGAAGCATCTGGACACTCATCCCAAGGAACAGGTTATAGATGCTCTCATCAAGGCTAGCGCCTCCTCGATTCAGACGCaccagcaacagcagcagcatcaTCAACAACAGCAAACTCCTACCCCGGCACCAGCGGCAACGTCACCACCGGTATCGCTGCAACCTTCGCCGCAAGCTTCACCGCAAGCTTCACCGCAAGCCCCTACCTCTATTCAGACGCCTCAAGCGTCGCCCCAAGTCTCGCAGAATTCAGCTCACATTTCCGCTCATTCGCCGTATCCCATAGGACCCATCTTCGAATGTCCGCCCATAAGTACTATGATGCCGCCGCAGTTTACCTCGTTCAGTTATCAACAATTTGTCAACAATGGGACCATGATGATACCGCAGTACGCGATGGCACCGCAGGCCAATCAGATGATGCAGATGCTGTACAATCCGTACGGTATGTACCAACAGCAGCAAATACCCACCGTCCAAATGATCTCACCGGTTGCAGCTATCCCAGGCGCCGCGAGGATCCGACCAGTGGTCACCATGGCCGGAGAGAACAATGTCAGAACCGCACTGGCAATTCCTGTAAATAGTCCCGAGCCGAAGCAGATCCTGCCTGAGATTTTGCCCGATGCCGAACCTGAATCCGGGCAAGTTATGCCGGATGTGAACCTACCGGACTCGCCTGTATTGCAGAACGAGGACGCGTCCATCAGACAGGAGGAGAGCGACAACACGGCGTTGTCGATCGATCACAGAGGACAGCAGATGCAGAGTACCGCATCGCCTGGTGAAAGTACAGTGCAGCACGGGTACAACGTTATTCCTAGGTCCATCACAATCGCCTGCGCCATGAATAATACCAACGACGATAAGGTGGAGAGTGTTCTACCGGACATGGAGGACGAGGAGCCGTCGAATAACATTTCGACCGTGGACTTGCAGTGTAAATCTGTAACGTACGAACAACCTGAGGCACAACAGTTTGCGCAACAGGTTTTGCAAGAAGGGTACGTGAGTATATCCAATAGGAAAACTAACGCAACGAATGATGTTGACTCTATGGCGTGCGAGCACGAATCGGAAGTGATGAGCGACGATAGACCGGCGAGCCGCGACAGCAGTAACGTTCCATCGCCGCGGGATCCAGTAGCGATAGATGCATTGAAAGACTCTATTCAACCCGAGCTTAATTCGGTGGAAAAGTTGGAGAATTTGATAACCATAATGGAGACAGAGCTTAATAACGCTTCgcttgaaaaagaaaatagctTGTCGAGTGAACGGGAGAGATTGATGGATACGAGGGAGAAATCGGATAGGGAGGAGACCGTGATTCACGACACCGTAGTGACAATTCTAGGCTCTCACGAGAAGGATCACATATTGCCTGATGTACAAGAGGATAACAATACATGGTGCCCGAACGATTATGTAGATAACGAACTCAGAACGCTAGAAAAGACCTGTCGttatttctcatataataCATGGTGCCCGAAAATAGATGACGGATTGAAAAGCCTAGAGAGACATTTACATTTGTATAAGTATAAGCATAGTTTTTCAGCACCCCCGTCTCCTGTCACGACGAAGAAGTGCCGCAGGACCGCAGTGCGTCGTTACAGCGCGCGATCGGAGCTCGGATCGTGCGAGAATCTCAGCTCGTATCATCATCGTGCTGGCTTTGACGACGCGGCGGCCATGCaggacgaggacgaggacgaggacgatgacgacgacgaggatatggacgaggaggaagagaagatCGACGAGGAGGATAATTTCGACGAGGCGGACATGGAGATCGAGGAGATTCCCAGTCCGCATACGCCTTTCGCGGAATGCGGCGTCAGATCGCATACGCCATTGTCCACGATCAGCGGTATCTCCGTGTTAAGAGTTAGGAAGGATCTCAGTAAACCATGTTCACCCACGTCCATACATTCGTTTCATCACGTGGACAGTGATAGCGTAAGTCACGACGAGGATAGTAATGGtgtagataataatattgtagataatattgcagaaaaagaTCCGATTGACTGTTCGCAAGTCGAAGAGAAGATTAAGACTGATCATCAGCATCAGGAGGCGCGCGCGACCGTGTGCGAAAATGTCGAGAAGGTTCAGGAATCGAGTAGTAGTAATAGTTATACATACCAGCAATCGGTGATAACCGAACACGTTAGTTCATTCCCTGTGATGCACTCGCAGCCATCCGTCTTGATGCACGAGTCGTATTCCGTGACGCCCAAGACGCAAAATCTCTTAAACTTGTCCGAGTCGATTAATCCTACAACCAGCACCGAGTCCAAGAGCTTTCATTCCACCAAATCTACGTTGATGCCGAAGCAATCGATGGAACTGCTCAACATAAATGAGGACGCTCACGCCGGACCGATGAACATGTTTGAATTTGACGGACTACAAATATTAGTTCCTAGTACATTTATAAGCGATTCGTCCCAGAAAGCGGTGAGTGCGACCAGCCAGCAATCTATGGCGAGTAGCGAGGGTGCAATAGGTATCGATGAGGAAGTGAAGAGCATCAATATGCGTGCCGATGAGACTATGCCGCCTAGAGGTGAATTGTCCGAACAAGAGAGCAACGGATGCACAGAGCCGTCTGCATGGCAGCTGTACATGGGTCAAGAATCTTCGCGCATGTCCACTTCCTACGATCTGTTGGCACGAGAAAGCTGGGAGGAATCGGAAGGATCTGACAACGAGATTAGCGGTCCGTTGTTGGATAGTAGATCGTTGGCCACGCACTTCACTTCGAGTCTGTTTCTGGACCGAGATCGGAAGACACCGACCAAACGGACGTTCAAGTGTTCCCACTGTAACGAGGTATTCGATTGTCCAAAAGAGCGCAGAGTTCATAGTACAACGGTACACAAGGAGGCAGTGCCCAGTAGCAGCAGAGACCAATTGGATCAGCCGGAGATGAAGGATATCAAGTTGCTGGACAATCGCGTGAATGTGTTCGAAGATATATTCGTGCCTGCCGGTCTGCAACACATACAACAGATGCAACAGATGTTCCATAATCAACAGCCGCTCCTGCAGCCGCTCCTGCACCAGCTACAGCCACCACCGTCGCAGCCTGGGTCGGACGGTTTGACCAAGGCTGAGACAGATCAGAAGATTGGCGAGAATTTGGTGATACCGTCGAGCATCGAGGTGACCTGCGCGATATGCAGCCAACGATTTAGCAGCGAAAAATCTCTGCAGATACATCACCGACGTATGCATCTAGCTGAGGTGAACAAACGCATACGCGAGAACGCCAAGTGCCAGATATGCAACGAGGAGTTCCCGTCGGTGTTGTTGTTCAACGCCCATCTGAAAATACATCCGTTGGAATGCGGACAGTGCGGTAAGTATTTTTATCGGAAGCAAAACTTCAAGCTGCATATGAAGCGGCACTTGGGCATCAAACCGTTTCCGTGCACCGTATGCGACAAGGCGTTCCTCACCAAGCAAAAACTGGACGAACATACCAACGGCCACACCGGCAACGCGCCCGTCAAATGTAGCTTGTGCAACGAGACTTTCCGCAGATATTCGAATTTGACGCAGCACAAGAATCGGCATCACCTCAACATCAAGAAGAAACTCAAAGACTATATATGCCACTGCGGCGAGGTGTTTCACACGAAGAAGAAGCTCGCCTGGCACAAGGAGACGCACGACGAGAAGCCCAAGGCGTGCACGTATTGCAACGAGCGATTCATCCACATGGCCAGTTTGACACGTCACATGCGTCGCGCCCACAATCGCCGATTCGTTCCTGATGCGCAGCGCGAAAGCGAGAACGTCGAGTGTCCTATTTGCAAGTGTATTTATCTACGATCGTCGCTGGCGGTGCACATGCGCGTGCACAACGGCGAACGGCCGTACGAGTGTCAGGTCTGCTCCAAGGCGTTCAGCACCAAGTGGAATCTGCAGTTGCACAAGTGGACGCATGCGGCACGCAGCACTAAGCCGTTCAAGTGTAATCAGTGCAGCGCGGCCTTTTATCGTCACAGCGACTACACGGCGCATATGAATTCCCACCGTAACGTGCGTCCTTACACGTGCAACTATTGCGGCGCGCAATTCATCCGCAAGTACAACTGTCTGCGACACGTGAAGGAGCACGAGGAGAACAAGGCGTACACGTGCGACGTATGCAACAAGACCTTTCATCGCTCGTACTATCTCAAGGAGCATCTGCGGGTGCACTCGGGCGCGCGACCGTACACGTGTCACATCTGCGGCAAGTCCAGCGGCACCAAGTCCAATCACAACAAGCACGTGCGAATCCATCACGCGCGCGAACCTGTAAATACCGAGAATTAA
Protein Sequence
MELSGTGTPVGAVACPVCTLYLREGISLQKHLDTHPKEQVIDALIKASASSIQTHQQQQQHHQQQQTPTPAPAATSPPVSLQPSPQASPQASPQAPTSIQTPQASPQVSQNSAHISAHSPYPIGPIFECPPISTMMPPQFTSFSYQQFVNNGTMMIPQYAMAPQANQMMQMLYNPYGMYQQQQIPTVQMISPVAAIPGAARIRPVVTMAGENNVRTALAIPVNSPEPKQILPEILPDAEPESGQVMPDVNLPDSPVLQNEDASIRQEESDNTALSIDHRGQQMQSTASPGESTVQHGYNVIPRSITIACAMNNTNDDKVESVLPDMEDEEPSNNISTVDLQCKSVTYEQPEAQQFAQQVLQEGYVSISNRKTNATNDVDSMACEHESEVMSDDRPASRDSSNVPSPRDPVAIDALKDSIQPELNSVEKLENLITIMETELNNASLEKENSLSSERERLMDTREKSDREETVIHDTVVTILGSHEKDHILPDVQEDNNTWCPNDYVDNELRTLEKTCRYFSYNTWCPKIDDGLKSLERHLHLYKYKHSFSAPPSPVTTKKCRRTAVRRYSARSELGSCENLSSYHHRAGFDDAAAMQDEDEDEDDDDDEDMDEEEEKIDEEDNFDEADMEIEEIPSPHTPFAECGVRSHTPLSTISGISVLRVRKDLSKPCSPTSIHSFHHVDSDSVSHDEDSNGVDNNIVDNIAEKDPIDCSQVEEKIKTDHQHQEARATVCENVEKVQESSSSNSYTYQQSVITEHVSSFPVMHSQPSVLMHESYSVTPKTQNLLNLSESINPTTSTESKSFHSTKSTLMPKQSMELLNINEDAHAGPMNMFEFDGLQILVPSTFISDSSQKAVSATSQQSMASSEGAIGIDEEVKSINMRADETMPPRGELSEQESNGCTEPSAWQLYMGQESSRMSTSYDLLARESWEESEGSDNEISGPLLDSRSLATHFTSSLFLDRDRKTPTKRTFKCSHCNEVFDCPKERRVHSTTVHKEAVPSSSRDQLDQPEMKDIKLLDNRVNVFEDIFVPAGLQHIQQMQQMFHNQQPLLQPLLHQLQPPPSQPGSDGLTKAETDQKIGENLVIPSSIEVTCAICSQRFSSEKSLQIHHRRMHLAEVNKRIRENAKCQICNEEFPSVLLFNAHLKIHPLECGQCGKYFYRKQNFKLHMKRHLGIKPFPCTVCDKAFLTKQKLDEHTNGHTGNAPVKCSLCNETFRRYSNLTQHKNRHHLNIKKKLKDYICHCGEVFHTKKKLAWHKETHDEKPKACTYCNERFIHMASLTRHMRRAHNRRFVPDAQRESENVECPICKCIYLRSSLAVHMRVHNGERPYECQVCSKAFSTKWNLQLHKWTHAARSTKPFKCNQCSAAFYRHSDYTAHMNSHRNVRPYTCNYCGAQFIRKYNCLRHVKEHEENKAYTCDVCNKTFHRSYYLKEHLRVHSGARPYTCHICGKSSGTKSNHNKHVRIHHAREPVNTEN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01255007;
90% Identity
iTF_00280132;
80% Identity
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