Basic Information

Gene Symbol
-
Assembly
GCA_028455795.1
Location
CM052253.1:10349260-10353846[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 8.9 8.5e+02 1.0 0.1 14 21 53 60 50 61 0.81
2 7 0.00038 0.036 14.7 0.3 5 21 61 77 58 78 0.93
3 7 8.2e-06 0.00078 20.0 2.4 2 21 87 106 86 107 0.94
4 7 0.00016 0.015 15.9 0.2 1 21 132 152 132 153 0.94
5 7 1.3 1.3e+02 3.6 0.1 1 9 161 169 161 174 0.85
6 7 2.5e-05 0.0024 18.4 2.1 1 21 178 198 178 199 0.96
7 7 9.9e-05 0.0094 16.6 5.6 3 23 209 230 207 230 0.93

Sequence Information

Coding Sequence
ATGGGTTCAAAGAGATTGAGACGGTGCTGGAAAATGGTTTCGTCGAATTTATTCGATGGTAAGATCGTGAATCCTCATCAAGACGAGCTGGCCCTGTTCAGCCTGAAGGACGATAGATTCCATCTGGAGGGTTTCGAGCTGTCGCCATCGGTCTCGATCAACCTGAAGAAGCACATATGCAATTGCGGCAAGATCTACAGCCAGAAAAGCTCCCTCGATCGACACCTGCGATACGAATGCGGGAAATTGCCGAACGTCCCCTGTCCGCAATGCGGCAAAATGTTCAAGCACAAACACCATGTGACGCAGCACCTGAAAAGCTATGGAGAGAGTCGATCGCGACAGCAGCAGCCGGCGTTGGTCCACGAGATGCAGCACGCGGAGAAACGAAGATTCGCCTGCGGCGGCTGCGGGAAATCGTACAAGTGGAAGGAGTCGCTTTTCAAACATAGACGCGTCGAGTGCGGGAAACTGCCGCAGTTCTCTTGCGAAGTTTGCGGTTACGCCAGGATACAACCCATCACGAAGACCTTCTACTGCGGCAATTGTAGCAAACAATACACCAGACGCGACTCTTTGTACAAGCACATGCGGTACGAGTGCGGAACGGAGCCCAAGTTCGGCTGCACCGTCTGCGGCCGGAGGTTTAAACGGAAACATCATCTCACGTATCACACGACGAACATGCACAAAATTCTTTGA
Protein Sequence
MGSKRLRRCWKMVSSNLFDGKIVNPHQDELALFSLKDDRFHLEGFELSPSVSINLKKHICNCGKIYSQKSSLDRHLRYECGKLPNVPCPQCGKMFKHKHHVTQHLKSYGESRSRQQQPALVHEMQHAEKRRFACGGCGKSYKWKESLFKHRRVECGKLPQFSCEVCGYARIQPITKTFYCGNCSKQYTRRDSLYKHMRYECGTEPKFGCTVCGRRFKRKHHLTYHTTNMHKIL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00763460;
90% Identity
iTF_00863495;
80% Identity
-