Basic Information

Gene Symbol
-
Assembly
GCA_028454225.1
Location
CM052217.1:7899543-7900523[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 9 0.0012 0.082 13.4 0.5 1 22 65 86 65 86 0.97
2 9 5.4e-05 0.0038 17.6 3.0 2 23 105 126 104 126 0.94
3 9 7.7e-05 0.0055 17.1 2.2 1 23 130 152 130 152 0.97
4 9 6.2e-05 0.0044 17.4 0.8 3 23 160 180 159 180 0.97
5 9 1.2e-05 0.00082 19.7 4.5 2 23 187 208 186 208 0.96
6 9 0.15 10 6.8 5.4 1 23 217 239 217 239 0.97
7 9 0.055 3.9 8.2 0.3 3 23 247 266 246 266 0.95
8 9 5.9e-07 4.2e-05 23.8 1.3 3 23 274 294 273 294 0.98
9 9 1.7e-07 1.2e-05 25.5 1.0 1 23 300 322 300 322 0.99

Sequence Information

Coding Sequence
ATGCGTTATACACAGTCATCGGGAATTATTCCGAGTAGCGTGTCCGCTTCCACTTCGGCATACGTCTTGTTATCTGTTTGCAGATCCACCGTGGCGAAGCAGACGCCTAAAGCTAGAGTCTTAGTTAGCCCCGAGGAGGTGTCCAGTAGATCCTCAATCGTCCGGCAATCGTTGTGCGACACcgaaaaatgttactcgtgcgacgcgtgccgcgaatcgttcccgaagaggatgcaactgttgaagcaccggcgaacgcgttgcaacgattcgccgaggaacgacggtcggcagcaggaaacgggtccgatcgagtgcaacgtctgccacaaggtcttcaagaaaaagaagtacctgaacgttcacaagacgctacacggcgcgccgcacatctgtcacgtgtgcggcgctaaattgacctcggagtactacctgaagatccacataagacggcacaacaaggagttcaccgagttctgtcagatctgcaacaagggtttctacctgaaggcgaccctgaggacccacatgagcgtgcacaccgacgacaagccctgcacctgcgaggtctgccacaagtcgttcggcaacagggtctacctgaggagccacatgaagatccacagcgagccggagaccaggaagaggtacaagtgcgagatctgcgagttccagacgttttacagttactgttacaaggagcatcagtcgacgcacaccggcgagggccaggtcgcctgcgaggtctgcggcaagctgatcagaagacagtacatgaagacgcacattcggatacacaccggcgagaaaccggagatctgcgagttctgcgggaaagcgttcagctcgaggaagtacctggtgaaacatcggagaacccacaccggggagagaccatacaaatgcggaatctgcgagaaacggttcacccaacgcggcaccctcagcgctcatttgcgccgacacgatggcgTCAAATGA
Protein Sequence
MRYTQSSGIIPSSVSASTSAYVLLSVCRSTVAKQTPKARVLVSPEEVSSRSSIVRQSLCDTEKCYSCDACRESFPKRMQLLKHRRTRCNDSPRNDGRQQETGPIECNVCHKVFKKKKYLNVHKTLHGAPHICHVCGAKLTSEYYLKIHIRRHNKEFTEFCQICNKGFYLKATLRTHMSVHTDDKPCTCEVCHKSFGNRVYLRSHMKIHSEPETRKRYKCEICEFQTFYSYCYKEHQSTHTGEGQVACEVCGKLIRRQYMKTHIRIHTGEKPEICEFCGKAFSSRKYLVKHRRTHTGERPYKCGICEKRFTQRGTLSAHLRRHDGVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00863455;
90% Identity
-
80% Identity
-