Basic Information

Gene Symbol
tio
Assembly
GCA_028455805.1
Location
CM052187.1:7551712-7558440[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 0.0065 0.61 10.9 0.2 2 22 452 472 451 475 0.90
2 4 0.00079 0.074 13.7 0.4 2 22 571 591 570 594 0.90
3 4 0.00026 0.024 15.3 0.4 2 22 675 695 674 698 0.89
4 4 0.0046 0.43 11.3 1.2 2 23 1310 1332 1309 1332 0.96

Sequence Information

Coding Sequence
ATGCTCGGTTCGGAACGGGCGGAGCTGTCCTCCGGTGGTCCGCCCTGGTCCCTCGGTTTCTCGCGGGAGGACGGAGTCGAAGGCTCTGGGCCAGGGCTGGCCGCCGACCTCCAAGGAGAGGAGGGCGATTGCGCGGAGGATGACGGGCCGATTAGCCCTAGCGAGAGGGTTTGCGCGGCTGCAGCCAAAGAGAACGAGGACGGCGATGCGACCGATGAGGAAGACGACGAGGATGCAACGCCGCCCACTCCACCGCCATCCGCCACAGCACGATTGAATCCTACGATTTTGAGGGACACCGGACCTCCGGACAGGGAACCGATGAGTCCGCGCTGTCCATCGAGAGATTCACGGGAATCGTCCGGTCCGGCGACTGGTAGCCCACCGCCGCCTGCAACGAGGAGCAGCGCGAGTCCGGTCAGCCCGAGCGGTATCGTGCCCCTTCCGCTCGGCGGTCACCCCCTGCTGCCACCGCATTCCGCGGCCATGATGGCGGCGTACTTGCAACAAACTCACCAGAGGCTGCTGCTCGGTCACTCGCCCCTGTCCCGGGGCTCGGTGTCGCCGCTGGTCTCGTCCTCGTGTTCGCCGCCCGCTGCCACCCCCGGCCTCCTGGTCTCGCCGAGCAGCATCGGCGAGGTCTCGCCATCGGCCACCCCGTTGCCAGCGGTCCTCGATTTCAGCACGAGAAAGGCCTCTTCGACGGAGGACGACGAGGACGAGCAGATCCTGAATCTAAGCAAACCACCGACCCCTTCCTCGTCGACGGAAACGAACAACGGGCCGTTGGATCTTTCGGTGCCGAGCAGGAAACGACCCGGACCGGAAGACTCGCCTCCGCCGGTTCGCAAGTCGTCGCGATTGGCGTCCGGGTCCGCTGCGGCTGCAGCAGCTGCAGCGGTTGCGGCTGCTAACGCGGCTCATCAAGACCCCGCGCAGGCCGTGGCGGCTGCCGCCGGATTCGGAAGGCCGCCCGTCGTATCGCCGTGGACGTCGCCCGTGGTCGCCTCGCATTTCCCGTATTTTGCCGCGGCGGTAGCGGCCGCCGCCACTAGTCAGCAGCAACTCTCGCCGAAGAGCACCGCCGGCGTGGTGGTGGACCACCATCAACTCTGGAACGGCAAGCTCAAGCCACCGTCCGCCCTGGAGAACAAGTATCAGCCCAGCGAGGCGACCAAAGCGCTCGAGAAGATGAGCGAGCTGAGCAAACTGGGCGGGGAGGATCTCTTCAGATCGGCATCCGGACCCGGTGCCGGTGCCGGGAACGTGTCTGGATCAACGTCCGGCAGTCGTCACAGCGCGTGGCAGTCTCATTGGTTGAACAAGGGCGCCGATCAGGCCAAGGACGTGCTCAAGTGCGTCTGGTGCAAGCAGAGCTTCCCCACGTTGGCCGCGATGACCACGCACATGAAGGAGGCGAAACATTGCGGCGTGAACATGCCCGTACCGCCTTCCGGATCCTCGCTACATCCCCAGCAGAGCAACGTGCAGAACATCCCGACGCCTCAGCCGCCTCATCTGCCTCAGACCACGTCGGGCGGGAACGCGGGCTCTGGTCCCGGGGCCGGAGGGTCTGCGACACCGAGCAGCAAACAGAGCCCGTCGGAATTGAATCTGTTGATCAAGGAGACGATGCCGTTGCCGAGAAAGTTGGTCCGCGGGCAGGACGTCTGGCTGGGCAAAGGGGCCGAGCAGACCAGACAGATTCTCAAGTGCATGTGGTGCGGCCAGAGCTTCCGCTCGCTCGCCGAGATGACATCGCACATGCAGCAAACGCAGCACTACACCAACATCATCTCCCAGGAGCAGATCATCTCGTGGAAGTCCTCGGACGAGAACAAGGGCGGCAGCGGTGGAGGAAACGGCGGCAGCGGTAGCGGTTCTGTGGCTGGCGGAGGTGGCGGCGGCGGTGGCGGTGGAACCGGTGTACCCGGTGGTAATTCCGGTTCCACAGGCCCCCACGCCGGCGGTACAGGAGCTCCGGGTTCCGGCGCGACCAGCAGTCACGTCAGCGCGGTGCTGACTTGCAAGGTTTGCGATCAAGCGTTCAGCTCGTTGAAGGAACTGAGCAATCACATGGTGAAGAATTCGCACTACAAGGAACACATTATGCGCTCGATCACCGAGAGCGGGGGCCGTCGTCGGCAGACAAGAGAGAAGCGCAAGAAGTCGTTGCCGGTGAGGAAACTGTTGGAGCTGGAGCGGGCGCAGAACGAATTCAAGAACGGCGACGCTGCCACGGGTCTCGGTCACGGTCTCGGGAAACACGCGGGCCGCATAACTTGCGAAAAGTGCGGCGACAAGATCGAGACCAGCATCTTCGTCGATCACATCCGGCAGTGTATCGGCGCGGGAACGGTGAGCGCGAACCAACGGAACTTTCTGAAGAACGCGTTGATGTCGAACCACCTGTCGGCGACGTTACCGCCGACCGAGAGCGGCCGGAAGAGCGCGAACGACGAGAGCTCGCCGCTGTCCTCTTCGAGGCACCATCGGTCTCCTTCGTCGGCCAGCGACGCGACCACTCCCGGCAAAGACACGCCGACCCCGACCGCCAACGAATCCACCGGAAGTTCCTCCTCCCCGTCCGTTTTGAACGCCATCGAGAAGCTAATCGAGAAGAGCTTCGATTCTCGCGCGAGGCACGGCGCGCCGGGCTTGCATCACGCTCAACCCGGAGCACCGATGGGCACGAGCATCCTCAAGCGACTGGGAATCGACGAGAGCGTCGACTACACGAAACCTCTTGTCGACCCGCAGACCATGAACCTCCTGCGATCGTATCAGCAACAGCAACAGCAGCAACAACAACAACAACACTACTCGACGAGCATGGCGGCTCGGAGAGAACGCAGCGGAAGCGAGTCCAGCTCGGTGTCGGAACGTGGAAGCGGCGGGAGAACCGACGCGATGACGCCCGAGAGGCGGCTCGATCTTTCCGCGGTCGGTCATTCGGAAAGGCTTTCGTCGCATCACCATCGAGTCACGCCGGACAAGCAGCTGGTTCCTCAGAGTCTGACAGCGGGACGCCATCACCCGGCCACGGAAGAATCCGGGGACGAGGAATCGTCCGCGGCCGCGACCACCGCCGCTTCCGGGGGATCGGGAGCTGGCGGCACGACGACATCGTCCGCGACGCCGGCAGCGACCGCGTCAGCGCCACCGTCCGCCTCGGCGACGGTGGTCGTGAAGAAGGAGCCAAAAGACGATGAAACCGACGACCGTGCCACAGCCGAGGAAGAGCAGTCGCAGTCGCAGACGAGCGGTCGAGAGGTGTACGTGAAGAAGGAGATCGTGGACGACTGCAGGGACGAGGAGGAGCAGAGTTCGTTCAATCATCGACGCGCCGGGAGCGGCAGCCTGCACGAGAGCGCGGAAGAGGGACGGGAAGTGATGTCGCCTCGAATAAATCCACCGACTCCCAGATCAACCGGGCAGATGGAGCAGCTGGTTCGCAGTCCGTGCAGAAACAGCACCAGCAGTCCAACGAGCAGCGACCGATCGGTTACTCCGCGCGGCACGCCCGACACGAAAGGCTCGAGCAGCCTAGGCGCGCTTTCCTCGATGTTCGACAGCTTGTCGGGTGGAGGCAGCGGAGGAAACGCCGGTGGCGGCGGAGGGAATGCTGGCGGCCCGGTCGACTCGCACGGCCGCAAGACCAGCAGCCATCCGTTGGCAGCGTTGCAAAAACTCTGCGACAAAACTGAGACGAGAGGCGGAAGCGCAAGCGGCAGCGGCGGTAGCTCCGGCAGGTCCGCCGGCGGGCCTGGCTCGACGTCGGGCTTAGGATCGGCCGCGGGCGGCGGAGGGGGATCTGGTAGCACACCGGGATCCGGTACCACGTCGGGATCCGGAACCACGCCGGGCGCCATCTTGGCGTTCAGCTGGGCCTGCAACGACGCCGTGGTCACGGCCGATTCGATCATGAAATGCGCCTTCTGCGACACGCCGTTTATCTCGAAGGGCGCGTACAGGCATCACCTCTCGAAGATGCACTTCGTGAAGGACGGCGTGATCCCGGACCCGCTGACGATCGGCCGATCAGCCGCGGCGGTCGCAGCTGCGGCTGCCGCAGCCGCGGCGGCCGCGGTCTCCCAGAACCCTGCGGCGGGACCGGCGACCGGTCACAGTTCTTCCTCGCCGCCAACGTCCCAGCGCAACAAGTCGCCGCCGCTTTCGCAGGCGAACGGTAGCCCGTCACAGTCAGCGGCCTCTCCCCTGGAGGAGAGTCCGCACTCAAAATTTCTCAAGTATACGGAGCTGGCCAAACAGTTGTCCAGCAAATACGTATAG
Protein Sequence
MLGSERAELSSGGPPWSLGFSREDGVEGSGPGLAADLQGEEGDCAEDDGPISPSERVCAAAAKENEDGDATDEEDDEDATPPTPPPSATARLNPTILRDTGPPDREPMSPRCPSRDSRESSGPATGSPPPPATRSSASPVSPSGIVPLPLGGHPLLPPHSAAMMAAYLQQTHQRLLLGHSPLSRGSVSPLVSSSCSPPAATPGLLVSPSSIGEVSPSATPLPAVLDFSTRKASSTEDDEDEQILNLSKPPTPSSSTETNNGPLDLSVPSRKRPGPEDSPPPVRKSSRLASGSAAAAAAAAVAAANAAHQDPAQAVAAAAGFGRPPVVSPWTSPVVASHFPYFAAAVAAAATSQQQLSPKSTAGVVVDHHQLWNGKLKPPSALENKYQPSEATKALEKMSELSKLGGEDLFRSASGPGAGAGNVSGSTSGSRHSAWQSHWLNKGADQAKDVLKCVWCKQSFPTLAAMTTHMKEAKHCGVNMPVPPSGSSLHPQQSNVQNIPTPQPPHLPQTTSGGNAGSGPGAGGSATPSSKQSPSELNLLIKETMPLPRKLVRGQDVWLGKGAEQTRQILKCMWCGQSFRSLAEMTSHMQQTQHYTNIISQEQIISWKSSDENKGGSGGGNGGSGSGSVAGGGGGGGGGGTGVPGGNSGSTGPHAGGTGAPGSGATSSHVSAVLTCKVCDQAFSSLKELSNHMVKNSHYKEHIMRSITESGGRRRQTREKRKKSLPVRKLLELERAQNEFKNGDAATGLGHGLGKHAGRITCEKCGDKIETSIFVDHIRQCIGAGTVSANQRNFLKNALMSNHLSATLPPTESGRKSANDESSPLSSSRHHRSPSSASDATTPGKDTPTPTANESTGSSSSPSVLNAIEKLIEKSFDSRARHGAPGLHHAQPGAPMGTSILKRLGIDESVDYTKPLVDPQTMNLLRSYQQQQQQQQQQQHYSTSMAARRERSGSESSSVSERGSGGRTDAMTPERRLDLSAVGHSERLSSHHHRVTPDKQLVPQSLTAGRHHPATEESGDEESSAAATTAASGGSGAGGTTTSSATPAATASAPPSASATVVVKKEPKDDETDDRATAEEEQSQSQTSGREVYVKKEIVDDCRDEEEQSSFNHRRAGSGSLHESAEEGREVMSPRINPPTPRSTGQMEQLVRSPCRNSTSSPTSSDRSVTPRGTPDTKGSSSLGALSSMFDSLSGGGSGGNAGGGGGNAGGPVDSHGRKTSSHPLAALQKLCDKTETRGGSASGSGGSSGRSAGGPGSTSGLGSAAGGGGGSGSTPGSGTTSGSGTTPGAILAFSWACNDAVVTADSIMKCAFCDTPFISKGAYRHHLSKMHFVKDGVIPDPLTIGRSAAAVAAAAAAAAAAAVSQNPAAGPATGHSSSSPPTSQRNKSPPLSQANGSPSQSAASPLEESPHSKFLKYTELAKQLSSKYV

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00232246;
90% Identity
iTF_00864269;
80% Identity
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