Basic Information

Insect: Lasioglossum calceatum
Gene Symbol: tp53
Assembly: GCA_963966675.1
Location: OZ016539.1:18615340-18616792[+]

Transcription Factor Domain

TF Family: P53
Domain: P53 domain
PFAM: PF00870
TF Group: Beta-Scaffold Factors
Description: P53 is a tumor suppressor gene product; mutations in p53 or lack of expression are found associated with a large fraction of all human cancers. P53 is activated by DNA damage and acts as a regulator of gene expression that ultimatively blocks progression through the cell cycle. P53 binds to DNA as a tetrameric transcription factor. In its inactive form, p53 is bound to the ring finger protein Mdm2, which promotes its ubiquitinylation and subsequent proteosomal degradation. Phosphorylation of p53 disrupts the Mdm2-p53 complex, while the stable and active p53 binds to regulatory regions of its target genes, such as the cyclin-kinase inhibitor p21, which complexes and inactivates cdk2 and other cyclin complexes [PMID: 20066118, PMID: 12629332, PMID: 1397838, PMID: 6544917, PMID: 19826090, PMID: 19776744, PMID: 6278740, PMID: 221923, PMID: 6318442, PMID: 20030809].This domain is found in p53 transcription factors, where it is responsible for DNA-binding. The DNA-binding domain acts to clamp, or in the case of TonEBP, encircle the DNA target in order to stabilise the protein-DNA complex [PMID: 11780147]. Protein interactions may also serve to stabilise the protein-DNA complex, for example in the STAT-1 dimer the SH2 (Src homology 2) domain in each monomer is coupled to the DNA-binding domain to increase stability [PMID: 9630226]. The DNA-binding domain consists of a beta-sandwich formed of 9 strands in 2 sheets with a Greek-key topology. This structure is found in many transcription factors, often within the DNA-binding domain.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 1 3e-66 8.4e-62 209.1 0.8 2 191 94 279 93 281 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	1	3e-66	8.4e-62	209.1	0.8	2	191	94	279	93	281	0.96

Sequence Information

Coding Sequence: ATGACTAATACAAACGGATTTTCAGACTCACAAGAGTCTGCGTTACTCGACGACGAAGCGTTTTCGGAGTTGCAGAGAGAAATCGGAAGCAATACTTTGCCATTATTAACAGGGGCTGAGATAGAAGACGATATCGAAGTAAAATTCGACATTGAAGGAACATACAATGaagtaaaatatgaaataaacaatttaacacAAAACTACATAGAAGAGAAACAAATGAATACCGAAGAATCTCCGGAATATTATCCGGCATCGGAAGCCTCTACTCCAGTAAGGGAAGAATTTCCTGGGtgttacaattttcaattttctctagCTAACCAGGAATCTACCAAACATCGGGTTTATTCTCCGTCATTGCGCAAAGTGTTCATCAATATGGATGAAACACTTCCATTACGTTTTAAATGGGATCCACCTGATGATGGTTTATATTTGCGCACCACTATGGTCTTCAGTTTAGATCAATATGCGAGCGATCCGGTCAGAAGGTGCCATAACCATATGGCATTAAACAATACAAGCAATCGAGATTACGATCCAAGAGTAATCAAACATGTTGTTCGTTGTTTGGATCATTCGAGCATGTATGAAGAAAGAAATGAGCATTTGTCTGTACTGACTCCACTTCATACACCTCAACCCGGGTCACAATATGTCCCAATGAATTTTAAGTTTTTATGTAAGAACAGTTGCCCATCTGGCATGAATCGCAGACCGACAGATTTAATTTTTACTTTGGAGGACCACAAAAAAACAGTACTGGGTAGACGAATACTTTCTGTCAGAGTTTGTAGTTGTCCAAAAAGAgacaaaaagaaagaagaatcaGAGATTCCAGACTCGCAACCTGACGTCAAGAAAAGAAagatttgtttacctgttgctaaAAAAGCAATGCCATCTTGCGATACGCACATCTTTAATGTTCAACTAAAAATAGTTGGGAAAGAGAACTATTTAGCGGTATTAAAATACGCATATGATATCATGGCCGGCCAGGCAGCGCGAACTAGCCAGTACGAATTCTTTAAACCATATATGGATGACATATTACGCAAAACTCCATAA
Protein Sequence: MTNTNGFSDSQESALLDDEAFSELQREIGSNTLPLLTGAEIEDDIEVKFDIEGTYNEVKYEINNLTQNYIEEKQMNTEESPEYYPASEASTPVREEFPGCYNFQFSLANQESTKHRVYSPSLRKVFINMDETLPLRFKWDPPDDGLYLRTTMVFSLDQYASDPVRRCHNHMALNNTSNRDYDPRVIKHVVRCLDHSSMYEERNEHLSVLTPLHTPQPGSQYVPMNFKFLCKNSCPSGMNRRPTDLIFTLEDHKKTVLGRRILSVRVCSCPKRDKKKEESEIPDSQPDVKKRKICLPVAKKAMPSCDTHIFNVQLKIVGKENYLAVLKYAYDIMAGQAARTSQYEFFKPYMDDILRKTP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00762327;
90% Identity: iTF_00763017; iTF_00866483; iTF_00863733; iTF_00762327; iTF_00865786; iTF_00861661; iTF_00864414; iTF_00860160; iTF_00865099; iTF_00863053;
80% Identity: iTF_00860160;