Basic Information

Gene Symbol
-
Assembly
GCA_949316025.1
Location
OX438921.1:24562261-24581929[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 0.00085 0.071 14.5 3.6 1 23 115 137 115 137 0.98
2 22 0.00027 0.023 16.0 6.9 1 23 143 165 143 165 0.96
3 22 0.0043 0.37 12.2 6.9 1 23 171 193 171 193 0.98
4 22 0.0013 0.11 13.9 1.3 1 23 199 221 199 221 0.96
5 22 1.8e-05 0.0015 19.7 0.9 1 23 227 249 227 249 0.97
6 22 9.8e-05 0.0083 17.4 0.0 1 23 255 277 255 277 0.98
7 22 0.0068 0.57 11.6 0.1 2 21 283 302 283 303 0.94
8 22 0.0068 0.57 11.6 0.1 2 21 339 358 339 359 0.94
9 22 0.0068 0.57 11.6 0.1 2 21 387 406 387 407 0.94
10 22 0.0068 0.57 11.6 0.1 2 21 443 462 443 463 0.94
11 22 0.0068 0.57 11.6 0.1 2 21 499 518 499 519 0.94
12 22 0.0068 0.57 11.6 0.1 2 21 547 566 547 567 0.94
13 22 0.0068 0.57 11.6 0.1 2 21 627 646 627 647 0.94
14 22 0.0068 0.57 11.6 0.1 2 21 707 726 707 727 0.94
15 22 0.0053 0.45 12.0 0.1 2 22 755 775 755 775 0.95
16 22 0.055 4.6 8.8 0.2 3 22 805 824 804 828 0.92
17 22 0.0068 0.57 11.6 0.1 2 21 852 871 852 872 0.94
18 22 0.0068 0.57 11.6 0.1 2 21 904 923 904 924 0.94
19 22 0.00021 0.017 16.4 0.2 2 23 956 977 956 977 0.97
20 22 2.6e-05 0.0022 19.2 0.5 1 23 1134 1156 1134 1156 0.97
21 22 0.00018 0.015 16.6 1.4 1 23 1222 1244 1222 1244 0.96
22 22 7.4e-05 0.0063 17.8 4.3 1 23 1254 1276 1254 1276 0.97

Sequence Information

Coding Sequence
ATGACTCCTCTTGGTCCCCTCCAACTAACACCAGAAGAATGCAATGAGATCTTAATGAAACGGGCCCTGCAAGCCCAGGGCATAGCCACACCAGTAATAGATACATCACAGCTTAACCAAACTTTACTTAATGGGGGGTTGAAGGCTATGGAAGAGGCTACCAATCAGCAAGCTCAGGCAGAAACAATACAAACACCTGCCGTACAGCATCATCTGTTGCATGCTAAACAGGAGCCTGGGACGGCCAACAGTTCGCCTAAAGCGGTGTACTCGCAGACAGAGATGATGAATACTAACACAGTGATGACGACGGCGCCGCAGCCTGCTGTGAAGGAACGCCGCTATTCGTGCGACGAGTGCGGCAAGACGTTCTTGCTGAAACATCATCTCACTACGCATGCTCGGGTTCATACAGGTGAACGGCCCCACGTGTGCGTGCACTGCGGCAAAGCTTTCGCGCGTAAGCATTGTCTGAACACGCACATGCTACTCCACTCGGCGGACAGGCCGTACCGCTGCCACGAGTGCAAGATGGCGTTCACCCTCAAACACCATCTAGTGACGCACTCCAGGGTGCACAGTAGAGACCGTCCGTTCGTGTGTACGGAGTGTGGGCGTGGCTTCGCCCTCAACCGTCACCTCGTCACCCACAGCAAGTATCACGCCGGCGAGCGACCGTACGTCTGCTCCGATTGTGGAGAGAGCTTCGCGCAGAAGGAGCACCTGGTGATGCACAGCCGGTTCCACGGGTCGCAGTCCCCGTTCGTGTGCGCCGACTGCGGCGCGGCGTTCGCGCGCAAGTTCCAGCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTcaccatcacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTcaccatcacacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTcaccatcacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTcaccatcacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTcaccatcacacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTcaccatcacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAACTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTcaccatcacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAACTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTcaccatcacacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAATACAGTCACcatcacacacgcacacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCTCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACagtcacactcacacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTCACcatcacacacgcacacacacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAGTCAGTACAGTCACcatcacacacgcacacacacacacacacacacacacactcccagCTCGTGAACCACGGCCGCGTGCACGGCCGCGTGCCGCCCTCCTGCCCCGTCTGCGGCAAGGAGTTCCTGCAGAAGCGCACGCTCGTCGCGCACATCAAgACACACACCGGGGAAGGCGCCGAAGCTTGCTTAGAGTGTGGCGAGGCTTTCAAATGTAAATCGGATTTGCACCAACACTGTAAAATGACGCGACATTGTCTTCCACCACAAACTCATCAGCAGCAGCAGCAACAgcagcaacaacaacaacaacaacaacaacaacagcaACAGCAGCAACAACAACAGCAACAGCAGCAGCAACAACAACAAGCTACTGTAATAAAGCAAGatgattttaaaccacaaaTTGTACAAACGCAGCAACAGCAGAGACAAGTCCAGCAACAACAGAGACAAGTACAACAGCAACAGACAATAGTCATAGAGCAGGATGACTTCAAGCCGCAAATTGTGCAGAGACAAGTACAACAGCAACAGACTCTAGTCATAGAGCAGGATGACTTCAAGCCGCAAATTGTGCAGGTTATGGGTGGCGATGGGCAGATAGTGACAGAGAAAACTACACCAGGCTATGCATGTCCTGAGTGTGGATCATGTTTCAATACAAAGGAGGCGCTGACGCTGCACGTGCGCCTGCACGCGGGCGACCGCACCACCGTCACGGACCTGTGCGCGCTCACCGCCGCGCTGCAGCCCGGGCTCGTcgcgcacgcacacgcacacgcgcacgcaCCCAATCAACCGATACAAATTATCTCTTCAAACCCCAACAATGTGGTACACACGCAAGTCATAGCCACGAATCACCATGTGACGCCCGCACGGCCGAAGATACACTTTTGCGGCGACTGTGGGAAAGGTTTTGCGGCTAAACACGGCCTACTAGCACATCAAAGAAGACATCCGGATGGTAGCTGCACACTACGGACGCACGTTTGCGATCAGTGCGGGAAGGCATTCTTCCAGAAGAATCATCTCATGCTGCATCAGCGGCAGCACATGGACCTACCGCCGAGATCGAGTCAAGCGCAAGTGAACGCGCAAGCGCAACAGGAGGCGCAACAGGCTGCGCAACAAGCGGCGCAACAGGCCGCGCAACAGGTGCAGCAACAGGTACAGCAGCAAGTGCAACAACACCAAGTGCAGCATCAGACTAGCCTAGAAATGGATCAGGATCATCAGCAACCTACGCATATACAAGTGGTAACGAACAGGTCGGGGCAGGTGATCGGCAACCAGATAGTGGTGGGCACCGTGGGGCGGCGGCTAGTGGGGCCGCACGTACACATAGTGGGCCGTGAGACGAAACCCATCGCGCAGCTCAAACACCACCACACGAGGCATCACACTACCAGCGGGGACGTGAAAGAAGTCGGCGGGCTGGTCCTGTCGGCGGGCAGAGGGACGGGTCTCATCAAGTACGAGATCGCCCTCCCGCAGCCCACGTCAGTGGTCCAAGTGCAGCAGCTGGACTGA
Protein Sequence
MTPLGPLQLTPEECNEILMKRALQAQGIATPVIDTSQLNQTLLNGGLKAMEEATNQQAQAETIQTPAVQHHLLHAKQEPGTANSSPKAVYSQTEMMNTNTVMTTAPQPAVKERRYSCDECGKTFLLKHHLTTHARVHTGERPHVCVHCGKAFARKHCLNTHMLLHSADRPYRCHECKMAFTLKHHLVTHSRVHSRDRPFVCTECGRGFALNRHLVTHSKYHAGERPYVCSDCGESFAQKEHLVMHSRFHGSQSPFVCADCGAAFARKFQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSARSSRTSSQYSHHHTHTHTHSQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSVQSPSHTHTHTHSQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSARSSRTSSQYSHHHTHTHTHSQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSARSSRTSSQYSHHHTHTHTHSQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSVQSPSHTHTHTHSQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSVQSPSHTHTHTLPAREPRPRARPRAALLPRLRQGVPAEAHARRAHQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSVQSPSHTHTHTLPAREPRPRARPRAALLPRLRQGVPAEAHARRAHQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSVQSPSHTHTHTHSQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHINTVTITHAHTHTHTHSQLVNHGRVHGRVPPSCLVCGKEFLQKRTLVAHIKSVQSHSHTHTHTHSQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSVQSPSHTHTHTHTHTHSQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKSVQSPSHTHTHTHTHTHSQLVNHGRVHGRVPPSCPVCGKEFLQKRTLVAHIKTHTGEGAEACLECGEAFKCKSDLHQHCKMTRHCLPPQTHQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQATVIKQDDFKPQIVQTQQQQRQVQQQQRQVQQQQTIVIEQDDFKPQIVQRQVQQQQTLVIEQDDFKPQIVQVMGGDGQIVTEKTTPGYACPECGSCFNTKEALTLHVRLHAGDRTTVTDLCALTAALQPGLVAHAHAHAHAPNQPIQIISSNPNNVVHTQVIATNHHVTPARPKIHFCGDCGKGFAAKHGLLAHQRRHPDGSCTLRTHVCDQCGKAFFQKNHLMLHQRQHMDLPPRSSQAQVNAQAQQEAQQAAQQAAQQAAQQVQQQVQQQVQQHQVQHQTSLEMDQDHQQPTHIQVVTNRSGQVIGNQIVVGTVGRRLVGPHVHIVGRETKPIAQLKHHHTRHHTTSGDVKEVGGLVLSAGRGTGLIKYEIALPQPTSVVQVQQLD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-