Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0011 0.099 14.1 0.3 2 21 21 40 20 45 0.93

2 5 3.1e-06 0.00029 22.1 0.8 1 23 53 76 53 76 0.96

3 5 0.00025 0.023 16.1 3.9 1 23 82 105 82 106 0.97

4 5 2.2e-05 0.002 19.4 0.4 3 23 117 137 116 137 0.94

5 5 1e-05 0.00098 20.4 2.0 2 23 144 166 143 166 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0011	0.099	14.1	0.3	2	21	21	40	20	45	0.93
2	5	3.1e-06	0.00029	22.1	0.8	1	23	53	76	53	76	0.96
3	5	0.00025	0.023	16.1	3.9	1	23	82	105	82	106	0.97
4	5	2.2e-05	0.002	19.4	0.4	3	23	117	137	116	137	0.94
5	5	1e-05	0.00098	20.4	2.0	2	23	144	166	143	166	0.96

Coding Sequence: ATGATCAGAATCGACCTGGTACGGACGCACGCCAGGATCCATTCCGCAAGGGAAACTATCACTTGTGTAGAGTGCAATAAGAGATATATTAGCAGAGCGTCGTACGAGAACCATCTGAAGTACAGTCAGGCGCATTCGAAGCAGGATGTTCTGAAATACAAATGCTCTATGTGTGACAAAGGCTACAGATCTAAAGGGGAGCTGCGGGATCACGTCAACTACCAACACCTGGGGAAGACTCAACACAAGTGCCCAGTATGTGGgaaggcaTTGGCCACTCGTCGTTGCATCACGCGTCACGTCCGGCGTGCACATCACGATATCAAGGAGAGTCCGCGAGACAAGATATGTCAACAGTGCGGGAAGGCTTTTAGAgataaaaaaggtcTCCGCGAGCATGAGTTCATTCATACAGGCGAGCGCCCTCTGTCGTGCGAGATATGCGGCTGTACCTTCAGACAGAGCGCCTCCCTGTACACCCACAGGAAGCGAGTGCACAAAATATATCCGCAGAGGAAAAGCGTTGAACTCGTCGAGCCAAGTTGA
Protein Sequence: MIRIDLVRTHARIHSARETITCVECNKRYISRASYENHLKYSQAHSKQDVLKYKCSMCDKGYRSKGELRDHVNYQHLGKTQHKCPVCGKALATRRCITRHVRRAHHDIKESPRDKICQQCGKAFRDKKGLREHEFIHTGERPLSCEICGCTFRQSASLYTHRKRVHKIYPQRKSVELVEPS*

Sequence clustering based on sequence similarity using MMseqs2