Basic Information

Gene Symbol
-
Assembly
GCA_905220505.1
Location
HG992163.1:16624435-16642657[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.0036 0.34 12.4 0.5 1 23 293 315 293 315 0.98
2 12 0.0013 0.12 13.8 3.1 2 23 323 344 322 344 0.94
3 12 0.011 1 10.9 0.4 1 23 348 370 348 370 0.98
4 12 0.001 0.097 14.1 0.7 1 23 375 398 375 398 0.98
5 12 0.001 0.097 14.1 0.2 1 23 402 425 402 425 0.94
6 12 0.0028 0.26 12.8 0.1 2 21 442 461 442 466 0.92
7 12 0.00046 0.044 15.2 1.2 3 23 476 497 476 497 0.98
8 12 0.058 5.5 8.6 0.5 2 23 517 539 516 539 0.96
9 12 2.8e-05 0.0026 19.1 1.7 1 23 550 572 550 572 0.97
10 12 0.00015 0.014 16.8 5.3 1 23 578 600 578 600 0.99
11 12 0.23 22 6.7 4.5 1 21 606 626 606 628 0.95
12 12 0.00064 0.061 14.8 0.2 1 23 634 657 634 657 0.96

Sequence Information

Coding Sequence
atggAGGACGTGAAAGTTTGTAGAATATGTCTAGTGTCTAATGTGAAGATGTATGACCTACACATACATCCTCTGGAAAACTATTTCGTAAATTTAACTGGAATAAATCTTCTTAGTACAACGGAGTTACCATCATATGCATGCTATGAGTGTGTAGCCCTAATGAAGAAGTATTACCAGTTCAGAGAGAAGTGTTACAGAGGGCAGAACACtctctataaaatattaaacaccaGAGGAAAGATAACAGAAAAAGAACTGCTGCAGGTTGATAGAAAAAATTTACAACTGTCTCACTTTGCTATTCAAGTCAACTCTAAGCCAATACACCAAGTGTACCAAGAACAGCAGTATACTGAACCTTATATAATAAAGGAAGAAGAGATTGAAACAAAATCCAAGTCCTTTGAAACAGAAGAAGAACATTTTGTAAAGGAAGAGAATTATGATGACTTTCTACAACATTCATCCAGTGATGATGAACTATTATCACTGCATAAAAGCAATAAAGAACAGAAGAAAGCTAAAAGAAGAGAAAAGAAAAAGGTGAAGAAAGATAAGATGAAATTGGATGATATGGATATTACCCAGCAGTTGGAAGAGGAGTTGACCACAGAAGGCTTGACAGAATCACAATTAGAAATGCTAGAGGCAGTCCTAGAGCCAAAACCTGGGCCACGGAAGAAGACCCTCCCGCCGCTCCCCAAGCCCAAGAAACCGAAGCCCACTAAGACCAGAAATACTAAAAACACTGGCGGAGTGTTTGACGACGATATTGATTTGGAGGAATTTGTTACGATCATCACATTATCGATGGAAGATCAGCTTGAGGAGATCAACAAACGCCAGCACTCGTCCAACTATAAGAACGCGCTGTTCCAATGCAACCTCTGCTACAAGGGGTTTATAGATACGGCTGCTTGGAATCACCACGTCGCCAAACATGATCCTAGCGCAGGCGACATCGAGTGCCCAGTCTGCAAGTTTAGGTTCAAAACGAAGCGCACACTTCACAAGCATGCCTCCAACCACGAGAAGAAATACTCTTGTAAAGCTTGTCCCTACGTCTCTAAGACTGCAACACAAGCGAAACAACATCAGAGATGGCATCAAGGTGTCACATACAAATGTCAGTATTGTGATGAAATATTAACTAAGTGGACATCATATCTAAGTCACGTGAGGATCAAGCACCCGTCGGAGTTCATCTGCGGCGTGTGCGGATATTCCTTCGTCAGTAAGCTGGGGCTCACCATGCACAAGACCATGATGCACAAAGATGTTATTGAGAAGGCAGAAGGCGATGGTGAGAGAGAAGGTCCATACTGCAAGGAGTGTGACGTGGTGTTCATCTCGGAGGAGGCGTGGAAGCGGCACATGGTCACCTCGGTCAAACACTCGCAAGCCGCTAATTTTAAgaacGGGTGCAGGGAGTGCGGCGAGATATTCGGCAGTAAGGAGGAGTTGAGAGTCCATCACAGGAAGACGCACGCGCGGAAACGACCCATCAACTACGGGAAGAAACCCACCGTCATGACCTGGCCTACCAAGTGCGAGCATTGTCCAGAGCAGATCGCCAACGCGCGGGAGTACTGGGCTCACTTCCGGCGGATGCACCCCGACAAACACTACCCCATACAGAAGAACCATATCTGTGATATTTGCGGCAAGAGTTTTAGGGGCAATGCGTTCCTGATGTACCACAAGCGGACACACTCCGAGGAGAAGCAGTTCAAGTGCGGCACGTGCGGCAAGGCCTTCCACAACCGGACCAACCTGCACATGCACGAGAAGACGCACTCGGACCTGCGCCCCTACCCCTGCACCGTCTGCTTCAAGGCGTTCAAGTGCAAGGGCGCGCTCGACAGGCATCTACGgTGTCACACCGGCGTGAAGCCGTACTTGTGCGAGGTGTGCGGCAAGGGGTTCGGCCAGTCCAACAGTCGCAAGCTGCATGTACGTACTGTGCACCTCAAGCAGCCCTCGCCGTACGTGAGCCAGGCGAGGCTCGAGCGGCGCGGACGGACAAGGGACCACGTGCAACTAGTGTTCTAA
Protein Sequence
MEDVKVCRICLVSNVKMYDLHIHPLENYFVNLTGINLLSTTELPSYACYECVALMKKYYQFREKCYRGQNTLYKILNTRGKITEKELLQVDRKNLQLSHFAIQVNSKPIHQVYQEQQYTEPYIIKEEEIETKSKSFETEEEHFVKEENYDDFLQHSSSDDELLSLHKSNKEQKKAKRREKKKVKKDKMKLDDMDITQQLEEELTTEGLTESQLEMLEAVLEPKPGPRKKTLPPLPKPKKPKPTKTRNTKNTGGVFDDDIDLEEFVTIITLSMEDQLEEINKRQHSSNYKNALFQCNLCYKGFIDTAAWNHHVAKHDPSAGDIECPVCKFRFKTKRTLHKHASNHEKKYSCKACPYVSKTATQAKQHQRWHQGVTYKCQYCDEILTKWTSYLSHVRIKHPSEFICGVCGYSFVSKLGLTMHKTMMHKDVIEKAEGDGEREGPYCKECDVVFISEEAWKRHMVTSVKHSQAANFKNGCRECGEIFGSKEELRVHHRKTHARKRPINYGKKPTVMTWPTKCEHCPEQIANAREYWAHFRRMHPDKHYPIQKNHICDICGKSFRGNAFLMYHKRTHSEEKQFKCGTCGKAFHNRTNLHMHEKTHSDLRPYPCTVCFKAFKCKGALDRHLRCHTGVKPYLCEVCGKGFGQSNSRKLHVRTVHLKQPSPYVSQARLERRGRTRDHVQLVF*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01010643; iTF_00063855;
90% Identity
-
80% Identity
-