Basic Information

Gene Symbol
-
Assembly
GCA_905220505.1
Location
HG992147.1:25191272-25192288[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 2.7e-06 0.00026 22.2 0.3 2 23 25 46 24 46 0.97
2 10 0.00019 0.018 16.4 2.8 1 23 51 73 51 73 0.98
3 10 3.6e-06 0.00034 21.9 1.2 1 23 79 101 79 101 0.95
4 10 3.8e-05 0.0036 18.6 1.9 1 20 107 126 107 128 0.95
5 10 0.00089 0.084 14.3 1.7 2 23 140 161 139 161 0.97
6 10 2.6e-06 0.00025 22.3 1.5 1 23 167 189 167 189 0.98
7 10 1.2e-06 0.00012 23.3 0.6 1 23 195 217 195 217 0.98
8 10 3.9e-05 0.0037 18.6 1.0 1 23 223 245 223 245 0.97
9 10 6.6e-06 0.00062 21.0 0.3 2 23 252 273 251 273 0.97
10 10 0.00028 0.027 15.9 4.5 1 23 280 303 280 303 0.97

Sequence Information

Coding Sequence
atgtgtgtgactgttgggtgtatttatttatttacagacgCATCACAATTAGAAGATGCAGAAAAGTCCACCACATGTCCGGTGTGCCAGAAGAAATTCGCCAACCAAGGAAACGTGCGGCGCCATCTGTTAATACACGCGCGAGTCAAACACAAGTGTGAAGTGTGCAACAAACAGTTCCTCAAACAAGACCAActtcagcgccatctagcgcGCCACGAGCAGACCTCCGAGCACGACTGTGATCAATGCGGCAAGATCTTCAAAACCCCATCCAAATTGAAACAGCATGCGGTTACACATATCAAGGAGAAGTCGTATTTCTGCAACCAATGCCACCGGTCTTTCACCACGGAGCAGAATTTGGTCAAGCATCAAGGCAGGAGCAGATGCAGACGGCCCATAGACGAGCCTCTAACTTGCAATGTGTGTATGAAAACGTTTGAAAAGGAATTTCTGTTGAAAAGTCATTTGAGAAGACATGACCCGGTCCGGCCATTCTCATGTGACATTTGTGGAATGAGCTTTAAGCACAAGAGTACAATTGTCCGGCATATAAAATGGCATGAGGGGATAAAGCCGTATTCCTGTAAGGTTTGCAAGAAATCGTTCACACAGGCCGGTCTTTTGAAGCCCCACATGAGGGTCCACACTGGAGAGAGACCTTACCCCTGCCCGATATGCCTTAAGGATTTCTCCTACAAACATAACATGTTAAGACATGTGGCCAGACATAATAAGGTCAAGCGTCTGGTCTGTGAGATATGTAAAAAGAACTTTCCTAGAGAGAGTCGTTTGATTTATCACATGAGGATACACTTGGATGAGAATAGGTTCTTCTCATGCTATGTGTGTCCTAAAAAGTTTTCTCACCGGCAGAATGTGCTGAGACATTATATGAGGAAGCACCCGGGACATACTTATGATTGTACCGACACAGATGCCAAAGTAGCGTTGAGGGTCTGGGATAAGGTGAAAAACACTTTCTTGGTTGAGCCGGAAGAGATTCTGGGTTAA
Protein Sequence
MCVTVGCIYLFTDASQLEDAEKSTTCPVCQKKFANQGNVRRHLLIHARVKHKCEVCNKQFLKQDQLQRHLARHEQTSEHDCDQCGKIFKTPSKLKQHAVTHIKEKSYFCNQCHRSFTTEQNLVKHQGRSRCRRPIDEPLTCNVCMKTFEKEFLLKSHLRRHDPVRPFSCDICGMSFKHKSTIVRHIKWHEGIKPYSCKVCKKSFTQAGLLKPHMRVHTGERPYPCPICLKDFSYKHNMLRHVARHNKVKRLVCEICKKNFPRESRLIYHMRIHLDENRFFSCYVCPKKFSHRQNVLRHYMRKHPGHTYDCTDTDAKVALRVWDKVKNTFLVEPEEILG*

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

90% Identity
-
80% Identity
-