Basic Information

Gene Symbol
-
Assembly
GCA_014465815.1
Location
CM025330.1:11918380-11967022[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.036 4.2 9.3 0.2 3 23 391 413 389 413 0.90
2 12 5.1 6.1e+02 2.5 0.3 3 23 567 589 565 589 0.91
3 12 0.0051 0.61 12.0 0.2 2 22 611 633 610 636 0.89
4 12 2.1 2.5e+02 3.7 0.6 2 23 652 674 651 674 0.90
5 12 0.05 5.9 8.9 0.5 1 22 679 700 679 703 0.90
6 12 1.6 1.9e+02 4.1 0.1 3 23 721 742 720 742 0.92
7 12 0.00029 0.035 15.9 0.8 1 21 747 767 747 768 0.95
8 12 0.0083 0.99 11.3 0.4 2 23 798 819 797 819 0.94
9 12 0.02 2.4 10.1 0.6 1 23 840 861 840 861 0.97
10 12 9.5e-05 0.011 17.4 0.2 1 23 867 890 867 890 0.95
11 12 0.00016 0.019 16.7 0.2 2 23 895 916 894 916 0.97
12 12 3.6 4.3e+02 3.0 0.1 2 11 925 934 924 935 0.88

Sequence Information

Coding Sequence
ATGGCCTATCTAGCGGACGATGACATCCATTTCTGTCTTCGCTGTCGACGTACCATTCTTGGATTGGGTGCCTACGTTGAACATCGATCCCAGAAAAACTGTCACCTTCAATCAGGAGAGACCAGCTCTCCAGCCCCATCCACTAGTACCGACAGCATAAAACAGCTGATCTCCATTTCCGCAAATGCAGGCAGACTGGTGACAACTGAACAGGGGACTCCTGGTGCACCCACTAGTGACGTGGATCCTGGACTGGAAGCAGATGACTTTTTCTCGTTGCTTGAACTGCAAAGCAGCACGAAAACGGGAAGTTCAGGTATTGCTGATTTGTCTGTGAAGGATCAGAAGAAACCGGTTGGTACAGGTGTGTTTACGAGGGGAAAAAGGAGGAGAGGGGAAGGGAAGGTGAAGGAAAGGGGTGTGAATTTGAGGAAATTGGTGGGGGGTAAGAAGTGGAGGAGGTTTGGTAAAGGGGGGAAGAGGAATAAAGTGAAGAAAGTAGTAAGTGATGAAGGAGTGGTTGCAAGTGGCGTATCAAAAGATTTGGTAGCTTCTGATTTTGTAGAAGTAACTTTCGAAACCCTGCTGAAGACTACTGAAACTAGACAAAACCCTGCTGAAGAAAGAAGAATTGAAAATAATATGGAAAGTTCTCAAGAAAACCTAGTAACAAATGAGGAGGAAATAGAGAAAACTGGAGACAAACCTTTTCCTGAACTATTTTCTGACTTCCCGCAAACTCCCACCTCGTTTCCTTATTTTCAAAACAATATTTCCTCTTCAACTGAAGAGGTGCTGCCTTCCACATGTGGAGACGAACTCGAAGAGGCAGCAGGAGATGAAGAAGAAGATGAAGAGGAAGAAGAAGTTGTACCTCCCAGATCCTATGGAGGAAAATGGAAGCCGGGAAGTAGTCCTAGTCTTCACCACCAGAGGAGTTTGAGTCTTGCGTCAGTGACCTGGAGTGACCAGGAAGTTGCCAATGCCCTGTCTTGGGGGTTAGAGTCTTCGACGTCTACTGATCCCGTGAACAAATCTACAATTATACAGAAACAAGGAAGTATGCCCCCGCCAGGCCACACACGAGGCAAATGGCTGCCGTCGAGCAACAACGACCTGCTGCCGAAGACGGGAACGGCGCAGTGGACGGGAAACCGCGTGCAGTACTGGTGTGGAGTGTGCAATCGGCGCCTCTCGTCGCGGGGCCTCTACGAGCGTCACCTCATGTCGCCCCTGCATACAAGGCGCACCAGGCACGAACGCCAACTGGATGAGGACTATTTGCAGCATAGGGCTGCTCCAGGAGGAGGAGTCACCAGTAGAAGACCACGTCGATTGTCTCGCAAACTGCAGGAGACTCTTGCTGCAAGAATGGCAGTGAGGGGAGTGAAGAAGACTGTTAAAAGGGACGGCAAGAAACCCCGCAACAAAACGATACAATGCGAAGTGTGTGACTTGCAAGTGGCCCGTCATCAGATCGGCAAGCACCTGGTCTCGCGTTTCCACTTGCGGCGAGCCGCAACCGAGCCGGAAGCCGCTCGCCGCATGACGCAGTCGCATGCGATTCCAGTGGCACGCCAGGCGCCATTCCGCTGTGCCATATGTTGCTTCTACTGCAACACGCTCGATAGCATGATGTTTCACTGGACCTCGAAAATGCACAGGGATCGGGATGCTGAGGTACCCGGTCGTTACTGGTGTGCAGTCTGCAAGCATTTCAGCGACACGAGTGCCGGAATGGAAGTGCATTTGCGTAGCGACCAGCACAAAGAAGTGGTCTCTGTTATCAACAAATCGTTCCCGATCGAGATTCAGAAGTTGGTGCCACTGAAATGTGACGTGGCCGGATGTGAACGGATTTTCCGCTACAATTCGCAGCTGAGGCTGCACTCCCGGTTAACCGGACATGTGCAGACCAGCGGCAGTGCGTCTGACTCCTACCAGGCTCGCATAAAGTGCAGTCAGTGCAGTTTTGTGGCCAACTCTAAGAGGAGGTTACTCATACATATGGTTTTTAGGCACAGGTTGAAGAAATTCTTCTGCTCCTACTGTGAGATGAGGTTCGACACCAGAGAAGAGGCGGTGCAGCATCGTCGCGGTGAGATGCACAAGTACACCGTTCTGCGCAAATGCAAAGCGCCCAATCAGCTGGCCAGAGCATGTGCGCATTGCTCGGAGGTTTTGAGTGATATACTCGCGCTCAAACAACACTTGGCGCAAATGCATCCTGATAAGGCACACAGATGCGCCAAATGCGGCGAGTCTTTCACAATGTGGCAAGAACTGTCTCATCATGTGAGGTCCAGCTGCCAAGGTCTGCCTGAGAAGTTGGCTACTAGTGATGACGTCACGACACCTTCCACCTCCAAAGCCGAAGTCGGTTCCGACTCAAGCTGTCCAAAGTGCAACTACACTTCATCGTCGAAAACAGAATTATTGTATCATGTTGCACTGCATGGTGATCCAGTCTATTCGAAAAATTATGGAAAAGAAGGTTCCAAATACGAGGTTCCGAAATTCGTCTGTCCCACCTGTTCGCGTCTAGTCCGCAAGGACAGTCTGCGCAACCACCTCACAACGCACACCGGCGAAAAGTGCCACGTCTGCAATCTTTGCGGCCTGGCGTTCTCGCGAGCAGATGTGCTGATCAGGCATCGCAAACTGGTGCACAAGGAAACGATGCAGTGTAGTATTTGTGACGTCATTTTCGCGAACGCGTTCTCGCTGCGTAGACACGTTCAGAATCACGACCAGGCACGGGAGAAGTCGCAGCGTTGCTCGGAGTGTGGCTTAGCCTTCATCCATTAG
Protein Sequence
MAYLADDDIHFCLRCRRTILGLGAYVEHRSQKNCHLQSGETSSPAPSTSTDSIKQLISISANAGRLVTTEQGTPGAPTSDVDPGLEADDFFSLLELQSSTKTGSSGIADLSVKDQKKPVGTGVFTRGKRRRGEGKVKERGVNLRKLVGGKKWRRFGKGGKRNKVKKVVSDEGVVASGVSKDLVASDFVEVTFETLLKTTETRQNPAEERRIENNMESSQENLVTNEEEIEKTGDKPFPELFSDFPQTPTSFPYFQNNISSSTEEVLPSTCGDELEEAAGDEEEDEEEEEVVPPRSYGGKWKPGSSPSLHHQRSLSLASVTWSDQEVANALSWGLESSTSTDPVNKSTIIQKQGSMPPPGHTRGKWLPSSNNDLLPKTGTAQWTGNRVQYWCGVCNRRLSSRGLYERHLMSPLHTRRTRHERQLDEDYLQHRAAPGGGVTSRRPRRLSRKLQETLAARMAVRGVKKTVKRDGKKPRNKTIQCEVCDLQVARHQIGKHLVSRFHLRRAATEPEAARRMTQSHAIPVARQAPFRCAICCFYCNTLDSMMFHWTSKMHRDRDAEVPGRYWCAVCKHFSDTSAGMEVHLRSDQHKEVVSVINKSFPIEIQKLVPLKCDVAGCERIFRYNSQLRLHSRLTGHVQTSGSASDSYQARIKCSQCSFVANSKRRLLIHMVFRHRLKKFFCSYCEMRFDTREEAVQHRRGEMHKYTVLRKCKAPNQLARACAHCSEVLSDILALKQHLAQMHPDKAHRCAKCGESFTMWQELSHHVRSSCQGLPEKLATSDDVTTPSTSKAEVGSDSSCPKCNYTSSSKTELLYHVALHGDPVYSKNYGKEGSKYEVPKFVCPTCSRLVRKDSLRNHLTTHTGEKCHVCNLCGLAFSRADVLIRHRKLVHKETMQCSICDVIFANAFSLRRHVQNHDQAREKSQRCSECGLAFIH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-