Basic Information

Gene Symbol
-
Assembly
GCA_014465815.1
Location
CM025321.1:3019935-3028682[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 0.066 7.9 8.5 3.5 1 23 268 290 268 290 0.96
2 14 0.005 0.59 12.0 0.3 1 23 295 317 295 317 0.97
3 14 2.5e-05 0.0029 19.3 1.2 1 21 323 343 323 344 0.96
4 14 0.079 9.4 8.2 1.5 1 23 351 373 351 373 0.96
5 14 0.45 54 5.8 3.8 1 23 379 401 379 401 0.98
6 14 9.5 1.1e+03 1.7 2.0 1 17 407 423 407 429 0.65
7 14 0.01 1.2 11.1 1.7 1 23 435 457 435 457 0.98
8 14 1.5e-05 0.0018 19.9 2.7 1 23 463 485 463 485 0.99
9 14 0.0012 0.15 13.9 3.4 1 23 490 512 490 512 0.98
10 14 0.00022 0.026 16.3 0.2 1 23 518 540 518 540 0.98
11 14 2.2e-05 0.0027 19.4 0.5 1 23 546 568 546 568 0.99
12 14 0.00058 0.069 14.9 0.4 1 23 574 596 574 596 0.99
13 14 3.8e-05 0.0045 18.7 1.8 1 23 602 624 602 624 0.99
14 14 4.6 5.5e+02 2.7 2.9 1 23 630 653 630 653 0.93

Sequence Information

Coding Sequence
ATGGACCAATCAGAGCGCGGGCTGGTGACGCATGCGCAGAACGTGAAATCGGAAAACTTTGATGAGAAAGAGGACGTCAATGCTGATATTACATACAACATCAAAGATGAAATAGAGATAAATGAATCATCAGCTCAGTTTGTAAAGAATGAATTTTGTTGTTGCATTCCAGTCGGTTCAGTAAAGCAAGAGGCGGATTGTGGAAATGTTTGTTTCAATGCGGATGATATAAAACATGACATAGATAAAATGTCAGTCTCATCCTTCGAAGAGGAATTTTTTAAAGGGTTTGATGTGGATCCACTCTCAATGAAGGTTGAATGTGGAAATGATGACAGTGGCTATGCAGATTTCAATGCTGAGGATATGAAAACAGATATCGACATAGATGAAACTCCAATCTCACTCATCAAAAAAGAATTCCTGGATGGGTTTTCTCCACATCCTTTTCTCTTGAAAAAGGAGCCAGAAGAGCCTTGTAGTAGTGTGGAGTCGCAATTCCATCTTGGTTACGAATTCAAACTTTTTGGACGAGTAGCAGTAGTTAGATTGTGTAGACTGGAAGATGAAGGGGCCGCAAATAGCGATCACTTGCGCCCTGGTGGTAGGAACCTGAACCATGATGTGCCTTCAGTTGAAACAGACACCTGTCGTAGTCAGAGAGACGCCAGATCGTTGATGAAATCACTGAGAAAATTCCGCTCCAGAAAATCAGAGGCCAAGCTGGATGCCAGGATAGTAAAGCAGGGACCGACGAGTGATAATGCTGAAACGAATGAAACATCTAGTAGTAAGGAAATCTTCAAATGTATATTGTGCAGGTTTTCATGCGTCAGCAAGAAAAGTCTTGAAATTCATTTACGACGCCATCCAGCCAAAAAACACGTTTGTAGTGATTGTGGCTATAATGCGAAAAGTGCAATGGATTTATGGGAACATTCCAATACTCATATTGGCAATAAACCTCATAAGTGTGATGTATGTGGTAAAATGTTTGCACATAAAGCGCATTTGGATATTCATAGGAGATGGTTTACTGTGGATAAACCTTACAAGTGTGATGTTTGCGATTATACGTCGGTTGAGAAAATTAATCTGACTTGTCATGTAAAACTTCACCCAGGCGAAAAACGTTTCAAATGTAGCGTATGCAAATCCTCGTTTATGGAGTTATGTAGATTGAAGGATCACGAGAGGTCTCACAAAGGAGGGAAACCTTACAGCTGTTCAATGTGTGATTACAAGAACTTCAGTTTGAAAAGTCTATATTTCCATAAAAGGATTCATACTGAGAAAAAATGTTTTAGCTGTGACAGTTGTGATTTCAAGACTTCTAGGTCTAGCAAGTTGGATGAACACTTTAGAATTCACAATGGAGACAAACCTTATAAATGTGACATTTGTGGTCACAGAGCCACCAGGCTGGGACACTTGAAATTGCATATTAGAACTCATGGCAATAAGAATTACTGCTGTGATCAGTGTGATTACAAAAGCTATGATTCAAGTGGTCTGAAGATTCATAAGAGAACCCATTCTGGTGAAAAGCCTTTCAGCTGCGATCTGTGTGATTACAAGGCCATTAGTAAAATCAATTTGGTGAATCACATAAGAACCCATACCGGTGAAAAGCCTTATAGCTGCGATCTGTGTGATTACAAGGCTATTCAAAAATCCTCTTTGGTGAAACACATAAGAACCCATACCGGTGAAAAGCCTTATAGCTGCGATCTGTGTGAATTCAAAGCCATCAGTAAATCCTCTTTGGTGACTCACATAAGAACCCACACTGGACAAAAGCCTTACAGCTGCGATCTGTGTGATTACAAGGCTAAACAGAAATCCACTTTGGTGAGGCACAGAAGAACCCATACTGATGAAAAGCCTTATAGCTGTGATCTATGTAATTACAAAGCATCTGTGTTAAAAAATCTGGAGTGTCACAAGAAATCTCGCCACAATAAAAAGTGA
Protein Sequence
MDQSERGLVTHAQNVKSENFDEKEDVNADITYNIKDEIEINESSAQFVKNEFCCCIPVGSVKQEADCGNVCFNADDIKHDIDKMSVSSFEEEFFKGFDVDPLSMKVECGNDDSGYADFNAEDMKTDIDIDETPISLIKKEFLDGFSPHPFLLKKEPEEPCSSVESQFHLGYEFKLFGRVAVVRLCRLEDEGAANSDHLRPGGRNLNHDVPSVETDTCRSQRDARSLMKSLRKFRSRKSEAKLDARIVKQGPTSDNAETNETSSSKEIFKCILCRFSCVSKKSLEIHLRRHPAKKHVCSDCGYNAKSAMDLWEHSNTHIGNKPHKCDVCGKMFAHKAHLDIHRRWFTVDKPYKCDVCDYTSVEKINLTCHVKLHPGEKRFKCSVCKSSFMELCRLKDHERSHKGGKPYSCSMCDYKNFSLKSLYFHKRIHTEKKCFSCDSCDFKTSRSSKLDEHFRIHNGDKPYKCDICGHRATRLGHLKLHIRTHGNKNYCCDQCDYKSYDSSGLKIHKRTHSGEKPFSCDLCDYKAISKINLVNHIRTHTGEKPYSCDLCDYKAIQKSSLVKHIRTHTGEKPYSCDLCEFKAISKSSLVTHIRTHTGQKPYSCDLCDYKAKQKSTLVRHRRTHTDEKPYSCDLCNYKASVLKNLECHKKSRHNKK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-