Basic Information

Gene Symbol
GIS1
Assembly
GCA_948098915.1
Location
OX402566.1:2686483-2709575[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 11 0.019 1.7 10.2 1.8 1 23 337 360 337 360 0.95
2 11 0.074 6.4 8.3 3.6 2 23 366 387 366 387 0.96
3 11 9 7.8e+02 1.8 0.3 1 10 391 400 391 404 0.88
4 11 0.0042 0.36 12.3 7.5 1 23 418 441 418 441 0.98
5 11 0.00083 0.071 14.5 0.5 1 23 445 468 445 468 0.96
6 11 0.042 3.6 9.1 0.1 2 20 483 501 482 503 0.92
7 11 0.0044 0.38 12.2 2.3 3 23 531 552 530 552 0.93
8 11 0.26 23 6.6 0.0 2 23 562 582 561 582 0.95
9 11 2.1 1.8e+02 3.8 1.2 1 10 588 597 588 597 0.95
10 11 0.0006 0.052 14.9 1.2 1 23 616 639 616 639 0.95
11 11 0.00039 0.034 15.5 4.0 3 23 656 677 654 677 0.96

Sequence Information

Coding Sequence
ATGTCTGACTTAAAGTTATGCCGTATATGTTTAAACAAGGATGTGAAGCTATTCAAATTAGATCAGTGCAATTTGAAACAATACTACGAGCATATTATGCGGAGCAAGGTTGTGTCCAAAGATGAGTTGCCTCGTTTCTTCTGTTTCGAGTGTGCCGCGCTACTGCACAAGTATCACAAGTTTAAAGATAAGTGCAGCTACGCACAGAACACTCTGAAGAAGCTGGCATCTAGTGGATTTCTTACATACTATATGATTGAGGATATACGCAAGAACCGGTCAGACCTCCAACCATCATCAGATTACATCAACTACTTGTGCAGCAAGCGTATTAAAACTGTTAATATCAAATACAAGGCGGAATTGGAGCCTCTCGAAATGGAGAATGTCATTGTCAACTCTCTCCCTGATGATGAAGAGCCCTTCAAGTATGAGTACATACCGGATTCCGACCACGATAATGATTTAACTGTCAATATTATGAAATGTGAAAATGCCGAAGTCAACAAAACTGATTTTAAGATTAACACTGACATACCAACATGCACGGAATTTACTAAAACCACTCCAGTGTTTTCAAATACTAGCGCGACCACTGAAACTGACTTGATTCTCCTAAAGACAGAACAAATAAGTCCAGCAAAAAAAGATGTCTCAATTTTACGGAACTTCTACTACCAATCAGACTATGAATCAGACAAAGACGATTCATCAAACGACCCTAGCTTCAGCATGGATGAAGACATTAAGGATACAAATGATGTTGAGAATACTGCATTAAAAGAAAAAAGAGTTACCAAGAGCAAAAAGGCTGTTAAAAAAAAAGACGACAATAAAACTGGTGAAAAAGTTAAGGAGTCTGATACAAACCATAGATTCGTTGGAATAATTCGCGAGCCAAAAGGAGAGCTCAGTAAAGGTAATTGGGAAACGAAACTGTTAACAGAAGACGAAGCAATGGAGCAGTTTAAGAAGAAAGAGTTTGACAGCAAGTATGAGAGAATGGAGTTTAAATGTATAAAGTGCTTTAAAGGGTTCTCTAAGAATGAAATGCTGTTGAGGCATAATAAGATGTGGCATGAGAAGGGTGAGAATGAATGCCGGTTCTGCCACATGCAGTTCAAATGGAAGAGCAAACTTCAAGTCCACATGATGAATCATTATTACATCTACAAGTGCCTACGCTGCGGTCTACAGTTCTACCTCAAGAACGGCGCGGTATTCCACGACGGCCACCACAATGGCGTGATACACAAATGCAAGCATTGTGGTGAAGAATACACGCACATATCGACGTACTACACCCACCTACGCACATCTCACCGCAACGCCCACGCGTGCAAACTGTGTGGCGCCACCTTCGTCAGCCAGACCGGCGTCGTCGTGCACATGAAACGGAAACACGTGATGCATGTGCCGAACTCGGAGGAGCTATCCACGAACATTTATTGTCAGAAATGCGAGATTTCGTTCGTGTCTCAGAGCGCGTACGACGAGCATCTATCTCAGTCAAAACTACATGAGGAAGAAAATAAGGAATTCAAACGAACCAGACGGAAACGAAGAGAGATCTTAGCGAACGCAGCCAGATGTATCCATTGCAACAAGAAGTTCAAGTCTAAAACGGAAGTGAAGGTGCATATAGCGACCGAACATCCCGGACAGAACAAAGTAGAACGAGTTGTTTGCGAGATCTGCGGCGCTGTTCTTTCTTCCGCGTACATTGAGATCCATATGAACAGACACACGCGTAAGAAAGTGTATCCGTGTCAGACTTGCGGCAAGGAGTTCCTGTGTGTCACCAGCCATAACACGCATCAACTGACCCACAGTGGCGAGAAACCTCACGCCTGTCCAATATGTCCAAAACGGTTCGGCCTGAAGGGACACATGGAAGTACACTACAAAAGAGTACATCTAAAGGAGCCGTACCCAAAAAGCGTACAAAAGCCCAAGCCGACCGACTGCCCGGTCTGCCACAAAACGTTTCAGTCTCGCTCACACATGGACACGCATCTACGAAGAGTGCATTTAAAGGAACCTTACCCTAAAAGGACGTACAATAGAAAGAACAGGAATCGTCAACCGACCGAAGTGCCATTATACGCTGCTTTACCGAAATAA
Protein Sequence
MSDLKLCRICLNKDVKLFKLDQCNLKQYYEHIMRSKVVSKDELPRFFCFECAALLHKYHKFKDKCSYAQNTLKKLASSGFLTYYMIEDIRKNRSDLQPSSDYINYLCSKRIKTVNIKYKAELEPLEMENVIVNSLPDDEEPFKYEYIPDSDHDNDLTVNIMKCENAEVNKTDFKINTDIPTCTEFTKTTPVFSNTSATTETDLILLKTEQISPAKKDVSILRNFYYQSDYESDKDDSSNDPSFSMDEDIKDTNDVENTALKEKRVTKSKKAVKKKDDNKTGEKVKESDTNHRFVGIIREPKGELSKGNWETKLLTEDEAMEQFKKKEFDSKYERMEFKCIKCFKGFSKNEMLLRHNKMWHEKGENECRFCHMQFKWKSKLQVHMMNHYYIYKCLRCGLQFYLKNGAVFHDGHHNGVIHKCKHCGEEYTHISTYYTHLRTSHRNAHACKLCGATFVSQTGVVVHMKRKHVMHVPNSEELSTNIYCQKCEISFVSQSAYDEHLSQSKLHEEENKEFKRTRRKRREILANAARCIHCNKKFKSKTEVKVHIATEHPGQNKVERVVCEICGAVLSSAYIEIHMNRHTRKKVYPCQTCGKEFLCVTSHNTHQLTHSGEKPHACPICPKRFGLKGHMEVHYKRVHLKEPYPKSVQKPKPTDCPVCHKTFQSRSHMDTHLRRVHLKEPYPKRTYNRKNRNRQPTEVPLYAALPK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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