Basic Information

Gene Symbol
-
Assembly
GCA_948098915.1
Location
OX402574.1:3136436-3144975[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 0.00053 0.046 15.1 0.3 1 23 240 262 240 262 0.96
2 10 8.1 7e+02 1.9 0.1 3 23 287 308 286 308 0.91
3 10 0.0011 0.091 14.1 1.8 3 23 331 351 329 351 0.91
4 10 7.3 6.3e+02 2.1 1.6 2 23 356 377 355 377 0.91
5 10 0.074 6.4 8.4 8.0 1 23 385 408 385 408 0.91
6 10 0.0095 0.82 11.1 0.7 1 23 414 437 414 437 0.92
7 10 3.6e-05 0.0031 18.8 0.4 1 23 443 466 443 466 0.97
8 10 0.00011 0.0091 17.3 2.3 1 23 472 494 472 494 0.98
9 10 3.6e-07 3.1e-05 25.1 0.6 1 23 500 522 500 522 0.99
10 10 1.1e-05 0.00095 20.4 1.3 1 23 528 551 528 551 0.97

Sequence Information

Coding Sequence
ATGAACGTGTATAAAAACAAAGGCCCAATAATCGAGCAGGGCCTGTGCAGATGCTGTGGCACTATTAAAAGATGCCGAATTTTAAACATAGAATACGAATGGCAAGGACAAAAAGAGGTTTATACAGATATGTTCATGGACTGTTTCGGTTTACTGCTCTCTCATCTAGAAGGGGAGGAGTTTGAAAAAGTAATATGTGCTACATGCGTGTCTCGACTTCGGGATGCCACTGCTTTCAAACACCAGGTCCTGCAGTGTGAAAATAATTTACTAAAGAAGAAGATACATGTCCATGAAGAGGATGGCGCTAGGATAGATATGAAGACAGAAGTGAAGGTCGAGGTGATGGAAAACATAATGAATTCAAAAGTGGCTCCTAACGAAACACAGTATGACGATGACCATTATAGTGAAGGCTTGGATAATGATGATAATGAAAAAAAAGTGAAAGTGGAAATCAAAGCACCGAGAAAGAAGAAGTTAATTAAAACCAAACTCAGTGTGAAATTGAAGAGCAAAGTGAAGCAAGAATACTTGAAAAAGAAGAAAGAACTCAAGGAGAAATTAAAGGCAGAGGAAATTGTAATCAATGAACCTCTGGTCCAGCCACCGCAGACGCGCCCGAAAATAATAGAAAAcgaaatgaaaagttttaccaacactatcactattgtagaaaactcatacgtctgtccgttctacacatctttcagtgattactactgcatgtactgcagagaaaccttcatcgatccggcaaaactcagggaacacacactagaacatgacccaacgagttttagagacatattgtacgataccaaaaaaatagctcaagtcgatgtagtcagagttgactgtagactttgcccgcagtcaataaacgatgtcgaaatactaaaagagcatctacaaactacacatggaaaatctttctatccggtcgttaacgaatttctcaagtttcgcctaacagttaatcatttgacgtgcattgaatgtggtagaacttttaaattctttcacgcgctaaaaaagcacatggctgaacatttcggcacttgtatatgtgatgtttgcggcgcgcattatttcgaggaacgtatactcctgattcatcagaaaaaacatcaggaaaacaaagcggagatccacacatgctgttactgtgataaatcatttaaatcaagacataacagatacttacacgaagctaaagttcataagaaggaatctgcgtacccttgcaacaaatgcgacgaagtattcttcacttacactctccgatacagacatctgatcgaagaccacggcgaggaaagaaagtatccatgtgacgtttgtggacgggtatacgactcgaggaagtcattacgtgagcataacagacgctcgcatttgaaaatcatgaagcatcaatgcgatttgtgtgatagacggttctatctaccctcaagattgaaagaacacatgtctacgcatactggggagaggaattaccgttgtgagtactgtggtaagagctaccctcggttaagagggttgaaagtccacatgcagtcgcatagtacagagaagaaattcagatgtgttttatgtaatgcatcatttactcagaatgttaatttgaagaatcatttgaagaggcagcatcagagtatggatatggaggatGATTATCAGAATAATATGATGTTGAATGTTAAATAA
Protein Sequence
MNVYKNKGPIIEQGLCRCCGTIKRCRILNIEYEWQGQKEVYTDMFMDCFGLLLSHLEGEEFEKVICATCVSRLRDATAFKHQVLQCENNLLKKKIHVHEEDGARIDMKTEVKVEVMENIMNSKVAPNETQYDDDHYSEGLDNDDNEKKVKVEIKAPRKKKLIKTKLSVKLKSKVKQEYLKKKKELKEKLKAEEIVINEPLVQPPQTRPKIIENEMKSFTNTITIVENSYVCPFYTSFSDYYCMYCRETFIDPAKLREHTLEHDPTSFRDILYDTKKIAQVDVVRVDCRLCPQSINDVEILKEHLQTTHGKSFYPVVNEFLKFRLTVNHLTCIECGRTFKFFHALKKHMAEHFGTCICDVCGAHYFEERILLIHQKKHQENKAEIHTCCYCDKSFKSRHNRYLHEAKVHKKESAYPCNKCDEVFFTYTLRYRHLIEDHGEERKYPCDVCGRVYDSRKSLREHNRRSHLKIMKHQCDLCDRRFYLPSRLKEHMSTHTGERNYRCEYCGKSYPRLRGLKVHMQSHSTEKKFRCVLCNASFTQNVNLKNHLKRQHQSMDMEDDYQNNMMLNVK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00377455;
90% Identity
-
80% Identity
-