Basic Information

Gene Symbol
-
Assembly
GCA_948098915.1
Location
OX402571.1:10789726-10813586[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.0061 0.53 11.8 4.8 1 23 157 180 157 180 0.95
2 17 0.0006 0.052 14.9 0.5 3 23 191 212 190 212 0.97
3 17 0.11 9.7 7.8 0.5 2 23 225 247 225 247 0.97
4 17 0.00057 0.049 15.0 3.4 1 23 256 279 256 279 0.97
5 17 8.7e-06 0.00075 20.7 0.7 2 23 291 313 290 313 0.95
6 17 2.7e-05 0.0023 19.2 0.4 2 23 342 364 341 364 0.96
7 17 1.1e-05 0.00093 20.4 1.2 2 23 374 396 373 396 0.96
8 17 0.11 9.6 7.8 1.9 3 19 402 418 400 420 0.94
9 17 3.2e-05 0.0028 18.9 0.2 2 23 426 448 425 448 0.97
10 17 0.0039 0.33 12.4 0.4 3 23 458 479 457 479 0.96
11 17 0.00058 0.05 15.0 6.9 1 23 484 507 484 507 0.98
12 17 0.0059 0.5 11.8 4.6 1 23 518 541 518 541 0.91
13 17 0.21 18 6.9 1.6 1 23 560 583 560 584 0.92
14 17 1.2 1.1e+02 4.5 0.2 2 23 590 610 589 610 0.86
15 17 0.17 14 7.2 2.0 2 23 616 637 615 637 0.97
16 17 0.0048 0.41 12.1 0.2 1 23 703 725 703 725 0.97
17 17 0.093 8 8.0 1.8 1 23 731 754 731 754 0.97

Sequence Information

Coding Sequence
ATGTCCTTAGTATTAGATGTTAAAGATATCAAAGAAGAAAAAGATAAACGTAAAGACCCTACCTCATTCCTCCCTGCAGAGGAGATGTGTTACGAGATTAAAAAGAAAAAAAAGAAGAAGAAAAAGAAAAAGCAGGAGGATCCCTTCAAGGATGTAGAAGAGAAGTTCTCTGTAAATCGGGAGCCAGATGTAACAGCCCTGGATCCTGATATAGGAATGCTGGACCCAGAGGTTACCATCAAAGTTGAGGATATTGAGGTGGATTTGAATATGGATGATTTCAATAACGATGATGGATTAGTGGAGGAACCCTACAACGGGGAGTACCAAACAGAACCATCCGTCAAACTCGAAGACCAGAACCGAGACGCCGTAGTCCTGACCTTCCAAAACATCATCAGCAACAACCTCATCAGTGACAAGCTCCTGAAAACTGAAAAGATCAAGATGGAGTCGCCTGGAGAGAATCACTTCTGCGAAGTGTGCCATCTAGTGTTCAAAACCGCAAAGTCCTTAGACACGCACCGGAAACGAACGCATAAGCATTTCAGAAAGTCTTTCGTAAACATTTGCAATGACTGCGGGATGTCTTATCAGTTTAAGAATAGTTTAGTCGCTCATATTAAGAGGAAACATGGACCCGATGCCAGTGTTGATGATATGAAGGAACGGACATGTGAATTGTGTGCGCTAGTCTTTAAGGGACAAGCCAGAATACGCATGCATATGAGGAGAAAGCACGGATACTACGAGGATTCCTTCAACCATGAATGCGAGTACTGTGGCCTGACATATGAGAAACAATGCAGCTTACTTGTACATATACGGAGAAAACATACTCACAAAACGAAACCTAAGAAAACCTGGTTAAACTGTCCGTATTGTGGCAGAGTTTTTGATAAAAGGGAAACCTACACTCGGCATATTCAAAGGAACCATCGGGTTAAGGAGGATGAAGTCAATTTGAGGGACGAAGATGAAAAGTTTAGACTGAAGTATTTGAATGAAAAGACAGGTGAGCTGACTTGCAATCAGTGTCCACTTGCCTTTTCCACGATTGGGTATCTTAAGTGGCATATGAGACGGAAACACAACGCTGTGATTGCAGATTTTAGGCTTAAATGTAAGATTTGTAACCTGTCATATGCAAATTCTGAGAGTCTTAAGAGACATGTTCGAAGAAAACATGACAAAGGTACTTTCTGTTATGAATGCAATAGACAGTTTTCGGATAGAGAATCGTTTTTGCAACATTCACACGCTAAAGTTATTAAAGAATGCACTTTATGTGGATTAATCTTTGCAAATAAAGGCGGTTTGGCCAAACATTTGAGAACTACGCACAAAATAGACGGTCCCAAGACAGTATTCTGTCCGGTCTGTAACCAAGGATTTGTAACCAAACGTCAATTGAAACCACATTACAACCGTGTACACTTAAAAGTTACTTACACATGTAAGTTTTGCAATAAAATCTTTAAAACAAGAGAGTGTTATAGGAAACATGTTATGACCAAACACCCGACCAGTGTCATCGAAGATATTAAGATGCATCAATGCGAACAGTGCCCGGAGAGTTTTAAAGATGAATTCGAGCTCTGTAAGCATAATAACTTCACGCACGGCGACGTCAAACCGATAGTTATCAAAAAAGAGGAGGATGATATCAAAAATGTGTTCAAATGCACAAAATGTAGCGATGAGTTTGAAACCTGGGATGTTCTACGAGTTCATTTTGAACAAAATCATCACCTGACTGAAAAAGTACAATGCCAAGTATGCGGGGATCTTCTGACCAGAGGCGATCTTGTCAAACACATGAAAAACCACGATGAAGTTGAAGTACAATGTCGGTTTTGTGAATTTAAGAGCAAGAGTCGAGTGAGCATGACGCAGCATATGTTAAGACATAAGAACGCTGCGACTCTTCACTGTGATTACCCTAATTGTAGATACAAAACATTCTACGAAGACGCAATGGTCAAACATAAGAAGCGACATCAAGAGTTAGGAGTTAAGTTACAGTGCGCCAGTTGTCCGTTCCAGACTATGAATAAATACATCTTGAGATACCACGAAGAAGCCCACAAAACGGGCAAGAAGAGGTACCAATGTGATAAATGTGATTACGCGACTATTCTTCCAGCTAATTTGGTTCAGCATAAGTATAAACACTCTGTGGAAAAGAGGTTTAAGTGCGAGGTTTGCCCATTTGCGACTAAGTATAATACGTCTCTGCGTTTTCATGTTAAAACGAAACATTGTGACCTTCCTAGTATAAGTAAGGGATGA
Protein Sequence
MSLVLDVKDIKEEKDKRKDPTSFLPAEEMCYEIKKKKKKKKKKKQEDPFKDVEEKFSVNREPDVTALDPDIGMLDPEVTIKVEDIEVDLNMDDFNNDDGLVEEPYNGEYQTEPSVKLEDQNRDAVVLTFQNIISNNLISDKLLKTEKIKMESPGENHFCEVCHLVFKTAKSLDTHRKRTHKHFRKSFVNICNDCGMSYQFKNSLVAHIKRKHGPDASVDDMKERTCELCALVFKGQARIRMHMRRKHGYYEDSFNHECEYCGLTYEKQCSLLVHIRRKHTHKTKPKKTWLNCPYCGRVFDKRETYTRHIQRNHRVKEDEVNLRDEDEKFRLKYLNEKTGELTCNQCPLAFSTIGYLKWHMRRKHNAVIADFRLKCKICNLSYANSESLKRHVRRKHDKGTFCYECNRQFSDRESFLQHSHAKVIKECTLCGLIFANKGGLAKHLRTTHKIDGPKTVFCPVCNQGFVTKRQLKPHYNRVHLKVTYTCKFCNKIFKTRECYRKHVMTKHPTSVIEDIKMHQCEQCPESFKDEFELCKHNNFTHGDVKPIVIKKEEDDIKNVFKCTKCSDEFETWDVLRVHFEQNHHLTEKVQCQVCGDLLTRGDLVKHMKNHDEVEVQCRFCEFKSKSRVSMTQHMLRHKNAATLHCDYPNCRYKTFYEDAMVKHKKRHQELGVKLQCASCPFQTMNKYILRYHEEAHKTGKKRYQCDKCDYATILPANLVQHKYKHSVEKRFKCEVCPFATKYNTSLRFHVKTKHCDLPSISKG

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01429284;
90% Identity
iTF_00377356;
80% Identity
-