Basic Information

Gene Symbol
pros
Assembly
GCA_029286875.1
Location
JAGSMT010000035.1:390655-391940[+]

Transcription Factor Domain

TF Family
HPD
Domain
HPD domain
PFAM
PF05044
TF Group
Helix-turn-helix
Description
Prospero is a large drosophila transcription factor protein that is expressed in all neural lineages of drosophila embryos. It is needed for correct expression of several neural proteins and in determining the cell fates of neural stem cells. Homologues of prospero are found in a wide range of animals including humans with the highest level of similarity being found in the C-terminal 160 amino acids. This region was identified as containing an atypical homeobox domain followed by a prospero domain. However, the structure shows that these two regions form a single stable structural domain as defined here [1]. This homeo-prospero domain binds to DNA.
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 1 3.7e-54 8.1e-50 169.9 0.1 50 153 59 162 55 163 0.98

Sequence Information

Coding Sequence
ATGGCGCGCGAGCGAAAATGGCTAATCAAATCCTTCCCCGAGTGGCGTCGTGAGTGTCGCCATTGTGCCGCTGAGGGCACCCGCGTATCGGCGTCGATGCGCTCGTTGAGATACGCCTGGGCCGCGGCCCTAATGAGCGGCGCGGGCCTATCTTGCGCTCCCAGCCTCCATGTCGAGGAGTTCTACTATATACAGATGGAGAAGTACGCGCGGCAGGCGATTAGCGAAGGTCTGAAGGCAGCTGATGACCTCCACGTGGCCGGAGACTCCGAGCTGTACAGGGTGCTCAATTTGCACTACAACAGGAACAACCACATCGAGGTGCCGCCCAACTTCCGGTACGTGGTGGAACAGACCCTGAGGGAGTTCTTCCGCGCCATCCAGGGCGGCAAGGATACGGAGCAGAGCTGGAAGAAGTCCATCTACAAGGTCATCTCCCGCCTCGACGACCCTGTCCCAGAGTACTTCAAGTCGCCAAACTTCCTGGAGCAGCTGGAATGA
Protein Sequence
MARERKWLIKSFPEWRRECRHCAAEGTRVSASMRSLRYAWAAALMSGAGLSCAPSLHVEEFYYIQMEKYARQAISEGLKAADDLHVAGDSELYRVLNLHYNRNNHIEVPPNFRYVVEQTLREFFRAIQGGKDTEQSWKKSIYKVISRLDDPVPEYFKSPNFLEQLE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-