Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 7 0.00098 0.049 14.8 2.1 1 23 98 121 98 121 0.96

2 7 0.043 2.1 9.7 3.3 1 23 130 153 130 153 0.96

3 7 0.014 0.7 11.2 3.6 3 23 164 185 162 185 0.95

4 7 0.0016 0.083 14.1 3.2 1 20 194 213 194 217 0.90

5 7 0.2 9.8 7.6 2.1 2 23 227 249 226 249 0.91

6 7 0.15 7.7 7.9 2.1 1 23 258 281 258 281 0.95

7 7 0.38 19 6.7 2.6 1 23 290 313 290 313 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	7	0.00098	0.049	14.8	2.1	1	23	98	121	98	121	0.96
2	7	0.043	2.1	9.7	3.3	1	23	130	153	130	153	0.96
3	7	0.014	0.7	11.2	3.6	3	23	164	185	162	185	0.95
4	7	0.0016	0.083	14.1	3.2	1	20	194	213	194	217	0.90
5	7	0.2	9.8	7.6	2.1	2	23	227	249	226	249	0.91
6	7	0.15	7.7	7.9	2.1	1	23	258	281	258	281	0.95
7	7	0.38	19	6.7	2.6	1	23	290	313	290	313	0.97

Coding Sequence: ATGGGCTTAGCATCCCTGGAAGGGTGGAGTCCAGTATCAGTCAGTAAAAAGCTGAGCCGGGCGTCGGAGCAGTCGGACGGGCGACTGAGGTGGTACTCCCATGACGTCTGTAGACATTTACAGATTGCTATCCTGGTTCTCTACTTCCTCGAACAGAGGCGAAGAGGTAGAGGGGTGGGCTGGAGCCTGTTAACCGCTATGGTTATGTTCCTATCAGTGTATAAAAAGGTTGTGGATTTCCCTTTTGCTGGTATGACGGGAAAACATACTCCCGAAGATTTACGAGAATGGTTTGTATGTGGTGATTGTGATTTTAAAACTACTACTAAAGAGTATTTTAAAAAACATACAGCGAGAAATCATGTTGCAGATGAATTACAAAAATGGTTTCAATGTGACTCGTGTAATTTTAAAACAAAAGGAAAATCTTATTTGCGACTACATAAGCTTAGAAGACATGTCCCAGATGAATTACAGCAATGGATATGCTGTGATAAGTGTACTTATGAAACCATAGATAAAAAAAATTTAAAAGAGCATTATAAACGAAGACATATTTCTTTGGATTTACAAAAATATTTTAAATGTGATCAATGCGATTTTACGACGAAAGATAAAAAGTATTTGAAGAGGCATAATGATTGGAAACATGGCACAGTTGCTTCACAAAAGTGGCTACACTGTAGGCAATGTGATTATAAAGCTAATAATAAAGAATATTTAAAAAATCATAACATTGTGAAACACGCGCCATTTAAATTGGAAGCACGTTTTGAATGTGATCAATGTTCATTCAAAACTACGTTGAATAAATATTTAGTTAAACATAAAAAAGCTAATCACCGATCGGATAAAGCTAAAAGATGGTTCCAATGTAGTCAGTGCGTTTTTAAAACCACTTGGAAAAGTAGTGTCCAAAAGCATATGTCCCGATTTCATAAAAATATGTTGGAAGATGTACGACCGCTTCTCTCATCTTAA
Protein Sequence: MGLASLEGWSPVSVSKKLSRASEQSDGRLRWYSHDVCRHLQIAILVLYFLEQRRRGRGVGWSLLTAMVMFLSVYKKVVDFPFAGMTGKHTPEDLREWFVCGDCDFKTTTKEYFKKHTARNHVADELQKWFQCDSCNFKTKGKSYLRLHKLRRHVPDELQQWICCDKCTYETIDKKNLKEHYKRRHISLDLQKYFKCDQCDFTTKDKKYLKRHNDWKHGTVASQKWLHCRQCDYKANNKEYLKNHNIVKHAPFKLEARFECDQCSFKTTLNKYLVKHKKANHRSDKAKRWFQCSQCVFKTTWKSSVQKHMSRFHKNMLEDVRPLLSS

Sequence clustering based on sequence similarity using MMseqs2