Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 3 7.6e-46 5.2e-42 143.4 0.1 12 94 6 88 3 91 0.97

2 3 1.8e-23 1.2e-19 71.1 0.7 46 95 88 137 87 144 0.94

3 3 6e-27 4.1e-23 82.3 0.7 28 94 140 204 136 217 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	3	7.6e-46	5.2e-42	143.4	0.1	12	94	6	88	3	91	0.97
2	3	1.8e-23	1.2e-19	71.1	0.7	46	95	88	137	87	144	0.94
3	3	6e-27	4.1e-23	82.3	0.7	28	94	140	204	136	217	0.91

Coding Sequence: ATGCTACTTTCTTCCGCAGTGCGAACCGGGAGCCCTGACTACATGTGCACGAAACTGCCGCAGCACTGGCGCTCCAACAAGACCCTGCCCATCGGCTTCAAGGTGGTGGCCCTCGGAGATGTGGTGGACGGCACCAGAGTTACCATCCGCGCAGGGAACGATGAAAACTGCTGCGCTGAGCTGAGGAACAACGTCGCGCATATGAAAAGCAGGGTCGCCAAGTTTAATGATCTCCGGTTCGTCGGCAGGAGTGGGAGAGAAGACGTAGTGGGACGTACCAGGGTCACCATCTGCGCAAGGAACGACGAGAACTGCTGCGCTGAACTGAGGAACAACGTCGCGCATATGAAAAGCAGGGTCGCCAAGTTCAATGATCTTCGCTTCGTCGGCAGAAGTGGAAGAGGTGAGGTCTTGTTATACTGGCACTCCAAAGATCAGCTGCATATGGTGGTGGTAGCTTTCGGAAGTTTGGTGGACGGCACCAGGGTCACCATCCGCGCAAGGAACGATGAGAACTGCTGCGCTGAGCTGAGGAACAACGTCGCGCATATGAAAAGCAGGGTCGCCAAGTTCAATGATCTCCGGTTCGTCGGCAGAAATGGAAGAAGTGAGGTATATCGGGAAAAGTGTGATTTTAATTTCCAAACCGCAGCTGTAAATGGTTTAGTGTTCCATTGTTGGGACCGAGAGCCCTCATCGCTGGCGAACGAGTTATACAACCTCCGGCGAATGAGAAGAGAGGTGTACAGTTACTGA
Protein Sequence: MLLSSAVRTGSPDYMCTKLPQHWRSNKTLPIGFKVVALGDVVDGTRVTIRAGNDENCCAELRNNVAHMKSRVAKFNDLRFVGRSGREDVVGRTRVTICARNDENCCAELRNNVAHMKSRVAKFNDLRFVGRSGRGEVLLYWHSKDQLHMVVVAFGSLVDGTRVTIRARNDENCCAELRNNVAHMKSRVAKFNDLRFVGRNGRSEVYREKCDFNFQTAAVNGLVFHCWDREPSSLANELYNLRRMRREVYSY

Sequence clustering based on sequence similarity using MMseqs2