Basic Information

Insect: Keiferia lycopersicella
Gene Symbol: ewg
Assembly: GCA_029255805.1
Location: JARACZ010000001.1:9083708-9093337[-]

Transcription Factor Domain

TF Family: Nrf1
Domain: Nrf1_DNA-bind domain
PFAM: PF10491
TF Group: Basic Domians group
Description: In Drosophila, the erect wing (ewg) protein is required for proper development of the central nervous system and the indirect flight muscles. The fly ewg gene encodes a novel DNA-binding domain that is also found in four genes previously identified in sea urchin, chicken, zebrafish, and human [1]. Nuclear respiratory factor-1 is a transcriptional activator that has been implicated in the nuclear control of respiratory chain expression in vertebrates. The first 26 amino acids of nuclear respiratory factor-1 are required for the binding of dynein light chain. The interaction with dynein light chain is observed for both ewg and Nrf-1, transcription factors that are structurally and functionally similar between humans and Drosophila [2]. The highest level of expression of both ewg and Nrf-1 was found in the central nervous system, somites, first branchial arch, optic vesicle, and otic vesicle. In the mouse Nrf-1 protein, Swiss-Prot:Q8C4C0 there is also an NLS domain at 88-116, and a DNA binding and dimerisation domain at 127-282. Ewg is a site-specific transcriptional activator, and evolutionarily conserved regions of ewg contribute both positively and negatively to transcriptional activity [3].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 4.1e-107 3.5e-103 344.8 0.0 1 212 83 301 83 302 0.96

2 4 6.8e-06 0.059 14.0 0.0 193 212 313 332 309 333 0.90

3 4 6.8e-06 0.059 14.0 0.0 193 212 344 363 340 364 0.90

4 4 6.8e-06 0.059 14.0 0.0 193 212 375 394 371 395 0.90

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	4.1e-107	3.5e-103	344.8	1	212	83	301	83	302	0.96
2	4	6.8e-06	0.059	14.0	193	212	313	332	309	333	0.90
3	4	6.8e-06	0.059	14.0	193	212	344	363	340	364	0.90
4	4	6.8e-06	0.059	14.0	193	212	375	394	371	395	0.90

Sequence Information

Coding Sequence: ATGGTCCGAGATTCAGACCAAGAAACGGAACAAGAGCAAAACTTCATCATGAACTCTGCCGTCAGCACCGAGTCTATGGACATGGCTGAGGAGGACATGTCGGCGGTAGAGGGATGCGGGCTGTCCGGCGGCTCTGAGGAGGAGGATGAGTGCGCATCATCGCCCGCCGGGTCCGCGTATGACGACAGCGGGGACATCATCAAGACCGCCATGAATGATGAAGTCACCAAACAGCTGGCTGCCGCTGGCCCAGTGGGAATGGCAGCCGCCGCTGCTATAGCGTCATCCAAGAAGCGCAAGAGACCGCACTCGTTCGAGACCAACCCGTCGGTACGCAAGCGTCACCAGAACAGACTACTTAGGAAACTCAGGCAAACGATAGAAGAGTTCGCGACCCGCGTGGGGCAGCAGGCCGTGGTGCTGGTGGCGACGCCCGGCAAGCCCAACACCTCGTACCGCGTGTTCGGCGCTAAGCCGCTCGAGGACGTGATCCGCAACCTGCGCTGCATGATCATGGAGGAGCTGGAGAACGCGCTCGCACAACAGTTCGGTCTGGGCGCGGGCGGGcaggcgccgccgccgccggccgaGGACCCCGCGCTGTTCGAGCTGCCGCCGCTGATCATCGACGGCATCCCCACGCCCGTCGAGAAGATGACGCAGGCGCAGCTCCGCGCCTTCATACCGCTCATGCTCAAGTACTCCATGGTGCGCGGCAAGCCGGGCTGGGGGCGGGACTCGACGCGGCCCCCGTGGTGGCCCAAGGACCTGCCGTGGGCCAACGTTCGCATGGACGCGCGCACCGAGGACGAGAAGCAGAAGATGTCCTGGACGCACGCGCTGCGCCAGATCGTCATCAACTGCTACAAGTACCACGGCCGCGAGGACCTGCTGCCCGCCTTCACTGATGACGACGACAAGCCGCACACGCCGCAGCAGACTATCGTCATCAACTGCTACAAGTACCGCGGCCGCGAGGACCTGCTGCCCGCCTTCACTGATGACGACGACAAGCCGCACACGCCGCAGCAGACTATCGTCATCAACTGCTACAAGTACCGCGGCCGCGAGGACCTGCTGCCCGCCTTCACTGATGACGACGACAAGCCGCACACGCCGCAGCAGACTATCGTCATCAACTGCTACAAGTACCGCGGCCGCGAGGACCTGCTGCCCGCCTTCACTGATGACGACGACAAGCCGCACACGCCGCAGCAGACTGTATCGAGCTGCATGTCGAGCTCGCACGACTCGCCCGGCGGGACCGGCAGCACCAGCcgccagcagcagcagcagatgACCACGCAGCAAGTCTGCATCGATCAGATGACGCTGGCTGATGTTGATATGTCAGGTTACGCGCCAGCAGTTCTTCAGACGATCACGAACCCGGACGGGTCGGTGTCGCTGATCCAAGTGGACCCCAACAACCCCATCATCACGCTGCCGGACGGAACCACGGCGCAAGTCCTTCACAGCGGCGAGGGCGGCGTAGTGCAGGCCATGGACGGCGAGGTGGCGGTCGACCTGAACGCGGTCGCCGAGGCCACGCTCAACCACGACGGGCAGATCATACTCACCGGCGAGGACGGCCATGGCTACCCGGTGTCGGTGTCGGGCGTGATCACGGTGCCGGTGTCGGCCAGCGTGTACCAGTCGATGGTGGCCAGCATGCAGGCGCAGGACGGCGTGTGCGTCGCGCCCATCGTGCAGGTGCCCATTAAGCTCGAGCCTTACGACACCTAG
Protein Sequence: MVRDSDQETEQEQNFIMNSAVSTESMDMAEEDMSAVEGCGLSGGSEEEDECASSPAGSAYDDSGDIIKTAMNDEVTKQLAAAGPVGMAAAAAIASSKKRKRPHSFETNPSVRKRHQNRLLRKLRQTIEEFATRVGQQAVVLVATPGKPNTSYRVFGAKPLEDVIRNLRCMIMEELENALAQQFGLGAGGQAPPPPAEDPALFELPPLIIDGIPTPVEKMTQAQLRAFIPLMLKYSMVRGKPGWGRDSTRPPWWPKDLPWANVRMDARTEDEKQKMSWTHALRQIVINCYKYHGREDLLPAFTDDDDKPHTPQQTIVINCYKYRGREDLLPAFTDDDDKPHTPQQTIVINCYKYRGREDLLPAFTDDDDKPHTPQQTIVINCYKYRGREDLLPAFTDDDDKPHTPQQTVSSCMSSSHDSPGGTGSTSRQQQQQMTTQQVCIDQMTLADVDMSGYAPAVLQTITNPDGSVSLIQVDPNNPIITLPDGTTAQVLHSGEGGVVQAMDGEVAVDLNAVAEATLNHDGQIILTGEDGHGYPVSVSGVITVPVSASVYQSMVASMQAQDGVCVAPIVQVPIKLEPYDT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -