Basic Information

Gene Symbol
topi_1
Assembly
GCA_037464855.1
Location
JAZBHA010000861.1:1-2110[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 13 0.0086 0.38 11.0 1.9 2 21 36 55 35 56 0.94
2 13 4.4e-06 0.00019 21.4 1.1 1 23 86 108 86 108 0.97
3 13 0.0016 0.069 13.3 1.0 3 23 116 136 115 136 0.95
4 13 0.29 13 6.2 1.1 2 20 155 173 154 175 0.90
5 13 0.00072 0.031 14.4 0.7 2 23 207 228 206 228 0.97
6 13 0.0042 0.18 12.0 3.2 2 22 271 291 270 294 0.88
7 13 0.0024 0.11 12.7 0.8 1 23 407 430 407 430 0.97
8 13 0.014 0.62 10.3 0.2 1 23 434 456 434 456 0.96
9 13 7.3e-07 3.2e-05 23.8 2.4 1 23 462 484 462 484 0.98
10 13 0.021 0.9 9.8 0.1 1 23 490 515 490 515 0.96
11 13 0.045 1.9 8.8 2.7 1 23 521 543 521 543 0.86
12 13 6.7e-05 0.0029 17.6 0.5 3 23 551 571 549 571 0.97
13 13 0.013 0.58 10.4 3.6 1 23 577 600 577 600 0.96

Sequence Information

Coding Sequence
AAATATTCAGATGAATCAGAAGCAAGtgaagtaattaaaattaagaaattggACAATTTCGATATATTTGgatatcaattgaaaatacatCTACCGATTATGATACGTTGTCAGAATTGTGAAACAAATTATccaacaaaatatcaatatcaacGACATCAATGCGAATTCAATGCCGATAAAGTTGTATTAAAACcaaatgttgatttaattaatttgaagaataatagtaataataatagaaataaaataaaatataattgcgGTATATGTAATCGACAATTTGTTAGTAAAAACAATTTGGAGCGTCATCAAACATCCCATGATGATTCACAAAACAATATCTGTGAATATTGtaataagaaatttgttaCCGAGAATCGTTTAAGAATACATAAAGAGAATCATTGCAAGAAAGCTGGtgatatattgaaattttatcgtAGTGATGTGACTGTATGgaaatgttgtaaatgttATGAAGTTTTCTCATCGAATATTACAGCCAATAATCATTATGACACCTGTGAAGCAACATTAGAAATCACTGAATCactaaaagaaatcaaaattgaaaatgagttatttatcgaaaaaatttcaactgaaattCTATTACAATGTGAATTTTGTAATCGTACATATGCTGATAAAGGGATTCtattaaaacatcaaaaaacaCATAGTACTGAACGAAATTATGAATGTGTTGCATGTGAAGCAATATTTGAATCATATATAAAAGCAGCACAACATTGGTCGAAACAATGTTCAGAAAAAGcaaatttattctatttaccAAAACTAACATATTGCGGATACTGTGATCGTACATTTAAATCGCACGAATTACTTTATAcacataaaatcaaaaagaaacattATACACCGAAACTTCACTCACAGAATCATGAAACAAGTTCAAATTCAATTACTgcaaaattcataaaaaatgaaaatacagttaacaaattaattgaagatgtTTTGGTAGCTCTAGAAATaccaataaatcaaaacatttgtgagaatatttataataatgataataataataaagaaaatatacagattgttgaaattaaaactgAACCACACGAAGagataaacaataatgaagaaaatacGAATGAACAGAAAAAACGTGGTCGTAAACGGAAATTACCAAAACCACAATCACCCAAAACTGGACCAGTTAATTTAGAAGATGGTTTTGTATATCAATGTGAAcgttgtataaaaattttcacaaatctAACCGATTTAGAAGCACATCATGAACGAGAACATGTTGCCACTTTTAATTGTGACGAATGTGGACAAgtCCTTCATAGTGCTCGTGCACTTTTAATTCATAGCCGAGCACATAAGAGCTTGAAACCGTACGTTTGTGAAACGTGTGGTCGAAGTTATTCGCAGACTTCACATTTATGGCAACATATGCGTTTTCATCAAGGCATTAAACCGTTTGCTTGTCCACATGAGGGTTGTGAAGCTCGATATACAATTCGACCAGATTTAAAAGATCATATACGTAAAGCTCATACAAGAGAACGTCCATTTAAATGTAGTGTTTGTGGGAAATGTTTTCTAACTGGTTCAGTGTATTATCAACACCGTTTGATCCATACAGAAGACCGACGATATGGATGTGatATGTGTGAGAAGAGATTTTTCCGTGCTGATGCtctaaataatcataaaaggATTCATACGAACGAACGTCCATATCCATGTTTTGTGTGCGGACGATTATTTCGACAAAAAGGTGATCGAACTAAACATTGCCGCACCCAACATCCTGatgcaataattaattaa
Protein Sequence
KYSDESEASEVIKIKKLDNFDIFGYQLKIHLPIMIRCQNCETNYPTKYQYQRHQCEFNADKVVLKPNVDLINLKNNSNNNRNKIKYNCGICNRQFVSKNNLERHQTSHDDSQNNICEYCNKKFVTENRLRIHKENHCKKAGDILKFYRSDVTVWKCCKCYEVFSSNITANNHYDTCEATLEITESLKEIKIENELFIEKISTEILLQCEFCNRTYADKGILLKHQKTHSTERNYECVACEAIFESYIKAAQHWSKQCSEKANLFYLPKLTYCGYCDRTFKSHELLYTHKIKKKHYTPKLHSQNHETSSNSITAKFIKNENTVNKLIEDVLVALEIPINQNICENIYNNDNNNKENIQIVEIKTEPHEEINNNEENTNEQKKRGRKRKLPKPQSPKTGPVNLEDGFVYQCERCIKIFTNLTDLEAHHEREHVATFNCDECGQVLHSARALLIHSRAHKSLKPYVCETCGRSYSQTSHLWQHMRFHQGIKPFACPHEGCEARYTIRPDLKDHIRKAHTRERPFKCSVCGKCFLTGSVYYQHRLIHTEDRRYGCDMCEKRFFRADALNNHKRIHTNERPYPCFVCGRLFRQKGDRTKHCRTQHPDAIIN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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