Basic Information

Insect: Iselma pallidipennis
Gene Symbol: Runx3_1
Assembly: GCA_037464855.1
Location: JAZBHA010000870.1:20120-26890[+]

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 2 4.2e-74 1.5e-70 234.4 0.0 4 129 36 161 33 161 0.98

2 2 1 3.7e+03 -2.9 0.0 6 30 433 457 430 458 0.77

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	2	4.2e-74	1.5e-70	234.4	0.0	4	129	36	161	33	161	0.98
2	2	1	3.7e+03	-2.9	0.0	6	30	433	457	430	458	0.77

Sequence Information

Coding Sequence: ATGCATCTGGCTGGTGAAGTTACTTCAACAACTGGAGGTGGTCATTATGACCGCAACTATGGTAATCTAACAGCTGAAATGTTAGCTGAAAGAACAATTGATGGACTGTTAGCGGAACATCCTGGTGAACTAGTACGTACGGGAAGTCCGCATGTGGTTTGTACAGTGCTACCACCACATTGGCGGTCGAATAAGACATTGCCAGTGGCATTTAAAGTGGTCGCATTGGGGGATGTTGGGGATGGTACTATAGTGACTGTAAAAGCTGGTAACGATGAAAACTATTGTGCTGAATTGAGAAACTGTACAGCTGTAATGAAGAATCAAGTTGCTAAATTCAACGATTTAAGATTCGTCGGACGCAGTGGACGAGGAAAAAGTTTTACATTAACGATTATTGTCTCAACATCACCGCCACAGATCGCTACATACAGTAAAGCTATCAAAGTGACAGTAGATGGTCCACGGGAGCCACGATCGAAAACCCGCCAACAGGGATTCCATCATTTCCCATTTGGACCACGGCCATTCGCACCTGATCCATTGACGGGCGCATTACCATTCAAATTGAGCGGAATCGCTCATCATCTAGCTGGTTTACCAGGCCACCCCACCGACTGGCCTGTATTAGGTGGCCGTCATCCATATCCACCAGGACCATTTGTACCACACCATCATTCACCATTTCCTCATCATATGCTAGCCGCTCTGGACCGTCCAATTAATACATCACCACGAATTGCTAGcgAACCTACTTCAACATCACTTGGTCCAATTTCAGTGAATTGTAGCACAACAACGGCACATAGTACTACATCACCTAAAACATCACCCAATCATATTGGTCTTCTACAAGCTACGAGTGCATCAcgatcatcaccatcaccggAAGATGATATATCTGTGACTGCGTCACCTACACCATctccacaaccaccaccagcaTTCCCGGGAGTtgcaccaccgccaccacttcaaaacaatcaattattcaacaatgCACTAGCAgcaagtttatttttaaatacaccattactaccaccacccaATCAATGGTTCTATTCACAATTCTACCCGCACGATTGGGCTTGGATGAATTTAAGACATCATTCGTTATTACCACGACAAACACCACATTCTCCACATGAAATCACTCAGAATCCGGATAGTTCGAGTAATACATTCGATGAGAATCGAGATGATAAGAATGATGAGAATGAAGATAAGaggaatattaaaaatgaaattggtatcaatttatcattaaataaatgcCGAAAAGCTGCTATTACGTTAGTGAAACAGAAAGATGAAGTTAGTAGCAGTGAAAAGGAGCACTTGAAATGTAATCGATTATCCGATGTTTGGAGGCCCTATTGA
Protein Sequence: MHLAGEVTSTTGGGHYDRNYGNLTAEMLAERTIDGLLAEHPGELVRTGSPHVVCTVLPPHWRSNKTLPVAFKVVALGDVGDGTIVTVKAGNDENYCAELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIIVSTSPPQIATYSKAIKVTVDGPREPRSKTRQQGFHHFPFGPRPFAPDPLTGALPFKLSGIAHHLAGLPGHPTDWPVLGGRHPYPPGPFVPHHHSPFPHHMLAALDRPINTSPRIASEPTSTSLGPISVNCSTTTAHSTTSPKTSPNHIGLLQATSASRSSPSPEDDISVTASPTPSPQPPPAFPGVAPPPPLQNNQLFNNALAASLFLNTPLLPPPNQWFYSQFYPHDWAWMNLRHHSLLPRQTPHSPHEITQNPDSSSNTFDENRDDKNDENEDKRNIKNEIGINLSLNKCRKAAITLVKQKDEVSSSEKEHLKCNRLSDVWRPY

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00852455;
90% Identity: -
80% Identity: -