Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0021 10 6.6 0.0 53 83 165 195 156 199 0.90

2 5 0.0045 22 5.6 0.0 53 83 211 241 197 245 0.88

3 5 0.00084 4.1 7.9 0.1 52 83 233 264 214 268 0.87

4 5 0.0039 19 5.8 0.0 53 83 257 287 246 290 0.85

5 5 0.0035 17 5.9 0.0 53 83 303 333 288 336 0.84

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0021	10	6.6	0.0	53	83	165	195	156	199	0.90
2	5	0.0045	22	5.6	0.0	53	83	211	241	197	245	0.88
3	5	0.00084	4.1	7.9	0.1	52	83	233	264	214	268	0.87
4	5	0.0039	19	5.8	0.0	53	83	257	287	246	290	0.85
5	5	0.0035	17	5.9	0.0	53	83	303	333	288	336	0.84

Coding Sequence: ATGCCTAGTAGTCCTAAAGTTGCGGGAAATACCAAGCCGTATTTCGGTCGCCGCGCGGGTCGGGGGGAGCGGGTCGGACGGCGGGCGCGGCGCGTGCGCAGCGAGCGGCCGGCCGCTGCCCGACGCGGCGCAGCGGAGCGGCTGTCGTACTTTTTGCTGAGCAAGTGCGATGAATATTTATTGCCCGCGCTCGCCATTAGCCGCTACCAGCAGCGCCGCCTAGCGGTACACGACTTTCGCGAAACTCGTGCGGAAATCGGAGCTAATACGGCGCGGGCTTGTCGCTGCGGGCGGGAAGGCGCGGTGAAAGCACTGTCGCAGCTACCGAACTGTCCACGACAAGGCGGGAGCTATACGGAGCTGTGCGGGTGGGAGCGGGACAGCAGTGGCGGGTCAAAAGACGATCGGCCCGCAACCCTGACCTCGCCCGCGCCCGGGTCGAGACGTATCCACGGGACGGACTCTACACTATATTCGTTCAACGATGTGAAGGCGACAGCGATGTCGTTCAACGATGAAGTATTGTCACCGGAAGCAAAGAATTACACTACCGTGCCGGAGGTGATGGCGACGTCGTTCAACGATGAAGTATTGTCACCGGAGGCAAAGAATTACACTACCGCGCCGGAGGTGATGGCAACGTCGTTCAACGATGAAGTATTGTCACCGAAGGCAAAGAATTACACTACCGTGCCGGAGGTGATGGTGACGTCGTTCAACGATGAAGTATTGTCACCGGAGGCAAAGAATTACACTACCGTGCCGGAGGTGATGGCGACGTCGTTCAACGATGAAGTATTGTCACCGGAGGCAAAGAATTACACTACCGTGCCGGAGGTGATGGCGACGTCGTTCAACGATGAAGTATTGTCACCGGAGGCAAAGAATTACACTACCGTGCCGGAGGTGATGGCGACGTCGTTCAACGATGAAGTATTGTCACCAGAGGCAAAGAATTACACTACCGTGCCGGAGGTGATGGCGACGTCGTTCAACGATGAAGTATTGTCACCGGAGGCAAAGAATATATACACTACCGTGCCGGAGGTGAAGGCGACAATTTCATAA
Protein Sequence: MPSSPKVAGNTKPYFGRRAGRGERVGRRARRVRSERPAAARRGAAERLSYFLLSKCDEYLLPALAISRYQQRRLAVHDFRETRAEIGANTARACRCGREGAVKALSQLPNCPRQGGSYTELCGWERDSSGGSKDDRPATLTSPAPGSRRIHGTDSTLYSFNDVKATAMSFNDEVLSPEAKNYTTVPEVMATSFNDEVLSPEAKNYTTAPEVMATSFNDEVLSPKAKNYTTVPEVMVTSFNDEVLSPEAKNYTTVPEVMATSFNDEVLSPEAKNYTTVPEVMATSFNDEVLSPEAKNYTTVPEVMATSFNDEVLSPEAKNYTTVPEVMATSFNDEVLSPEAKNIYTTVPEVKATIS

Sequence clustering based on sequence similarity using MMseqs2