Basic Information

Transcription Factor Domain

TF Family: Runt
Domain: Runt domain
PFAM: PF00853
TF Group: Beta-Scaffold Factors
Description: The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 4 7e-16 3.4e-12 47.0 0.1 94 129 114 149 107 149 0.95

2 4 0.085 4.2e+02 1.4 0.0 116 129 175 188 173 188 0.88

3 4 1.6e-07 0.00079 19.9 0.1 110 129 245 264 236 264 0.86

4 4 2.3e-07 0.0011 19.4 0.0 111 129 287 305 279 305 0.90

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	4	7e-16	3.4e-12	47.0	0.1	94	129	114	149	107	149	0.95
2	4	0.085	4.2e+02	1.4	0.0	116	129	175	188	173	188	0.88
3	4	1.6e-07	0.00079	19.9	0.1	110	129	245	264	236	264	0.86
4	4	2.3e-07	0.0011	19.4	0.0	111	129	287	305	279	305	0.90

Coding Sequence: ATGAGTGGACCGCCGACTCATTGCGGGCTGCGGGCGCGTTGGCGGCTCGGTGTGCGGGCGGGCGGCGGGGTCGACGTCGGCGACGGTCACGGGATGGAGCAGCTGACAAGTGACAGCGAGGTTAGTGCTTCACATGACGGCGGCCGCAGCCGCGGCTTGCGGCGGCGGGGCGTGCGGCCAGACGCTCCCCGCACCCGGTACGGTCGTGTCGGCTGGTGGGGTGCCAGCACGCGCGCCGCGTTTGCCACAAATCAACGGAGCTGCCGCGGCTTGAAAAATGACCGCGGAGGAACTCTAGACTGCGGCGGGAAGACCCGGCGCTGCCTGGCTTTGGGACGCAAGTCTTTCACGCTGACCATCACGCTGGCGACATCACCGCCGCAGGTTGCATCGCTGATGAAGGCCATCAAGGTGACGGTGGACGGACCGCGCGAGCCGCGTTCCAAGACGCGCCACCACGGATTCCATCCGTTCCATTTCGCGCCGCGGTTCGCACCTGACCCGCTCATGGGCGGACTACCCTTCAAGCTATCAGTGGACGGACCGCGCGAGCTGCGCTCCAAGACGCTCCACTATGGCTTCCATCCGTTCCACTTCGCACCGCGGTTCGCGCCAGATCCGCTCATGGGCGGGCTACCCTTCAAGCTATCAGGTGACGGTGGACGGACCGCGCGAGCCGCGCTCCAAGACGCGCCACCATGGCTTCCATCCGTTCCACTTCGCGCCGCGGCTACGTCACTGATGAAGGCCATCAAGGTGACGGTGGACGGACCGCGCGAGCCGCGCTCCAAGACGCGCCACCATGGCTTCCACTTCGCGCCGCGGTTTGCGCCAGACCCGCTCATAGGCGGGGCTACGTCACTGATGAAGGCCATCAAGGTGACGGTGGACGGACCGCGCGAGCCGCGCTCCAAGACGCGCCACCATGGCTTCCATCCGTTCCACTTCGCGCCGCGGTTCGCGCCAGACCCGCTCATGGGCGAGCTACCTTTCTTCCTTAAGTTCATTAAACAATAA
Protein Sequence: MSGPPTHCGLRARWRLGVRAGGGVDVGDGHGMEQLTSDSEVSASHDGGRSRGLRRRGVRPDAPRTRYGRVGWWGASTRAAFATNQRSCRGLKNDRGGTLDCGGKTRRCLALGRKSFTLTITLATSPPQVASLMKAIKVTVDGPREPRSKTRHHGFHPFHFAPRFAPDPLMGGLPFKLSVDGPRELRSKTLHYGFHPFHFAPRFAPDPLMGGLPFKLSGDGGRTARAALQDAPPWLPSVPLRAAATSLMKAIKVTVDGPREPRSKTRHHGFHFAPRFAPDPLIGGATSLMKAIKVTVDGPREPRSKTRHHGFHPFHFAPRFAPDPLMGELPFFLKFIKQ

Sequence clustering based on sequence similarity using MMseqs2