Basic Information

Gene Symbol
Tf2-12
Assembly
GCA_949358125.1
Location
OX442337.1:2468610-2499810[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 3.2 2.6e+02 3.1 0.8 2 11 262 271 262 283 0.82
2 12 0.76 62 5.1 0.0 1 22 288 311 288 314 0.85
3 12 0.004 0.32 12.2 2.0 2 23 422 444 421 444 0.94
4 12 0.0065 0.53 11.6 0.0 1 23 450 472 450 472 0.96
5 12 0.067 5.4 8.4 0.1 1 23 481 504 481 504 0.89
6 12 3.5e-06 0.00028 21.9 4.4 1 23 509 531 509 531 0.98
7 12 1.6e-05 0.0013 19.8 0.5 1 23 537 559 537 559 0.97
8 12 0.00061 0.049 14.8 3.0 1 23 565 587 565 587 0.97
9 12 7.4e-08 6e-06 27.1 0.2 1 23 593 615 593 615 0.98
10 12 0.047 3.8 8.9 7.8 1 23 621 643 621 643 0.99
11 12 0.09 7.3 8.0 0.1 1 23 693 715 693 715 0.98
12 12 2.1e-05 0.0017 19.4 1.4 2 23 721 743 720 743 0.94

Sequence Information

Coding Sequence
ATGGAAGTATTTCTATATAATTCAACTGTTTGTAGATTATGTGGAGAAGAAAACGATAATGGGACGTTCTTATATTCAAGTGAAGATAATCCTCAGAATATTAGTGATTTAGTCAACGCGTATTTGCCAATCAAGGTGTCTGATGATGGCCAGCTGCCTCGGACCATATGTCCCGGATGCACAATTCAGCTGGAAGCCACCGTGGAATTCATCAACCTAATAATCAATGGCCAGaaagCCATCCGATCTTTGTATCAAAGAGAAAAGGAATATAAGAAGAATATTCTGAAAACAACTGAGGATGAGGAAGTGTCTATAGAAAATGGGACCCAAGAAGTACTCAAATCCCCAGTCTACACAGAGGAACACCCAGCGTCACTCCAAGTAGCAGGCCTCGACAAGCCAAAACGTAAGCGAGGTCGACCTCCGAAGAAACACAAAACTCCTGAAGAGCTAGCCCAGGAAGCTGCTGCGAAACAGGAAGAGATAAAAGTGGTGGAGGAGGTTAAGAATGAGGAACCTACGGGGAAACGGAAACGGAGACATCCGGAGAGGTTTAAAGAAGTTGTTCAGGGAAAAGAACTTGAGAAGATATTCCTAGAAGAAGGTGTGATAGATAAGGAAGAAAATGACCAGGAAGTGCAGCAGGAGAAGGAAGATGTGAAGCCAGTCGTTCCGAAGGTGCCTGAGGTGATTGGGCACACTGAATCGGGGGAGCTGGTGGTGGTTGTCAAGGGGAAAGGCAGAGGCAGACCTAAGGGTCGTCTGCGCGTGACGCGCGAGAAGTGCGCGATCTGCGGCAAAGAGTTTTCGTGCGTGGGTCGCTACATGTCGCACGTGGCGGGGCACGGGCCCGTGCTGTACCGCTGCGCCGCGCCCGCCTGCGGCCGGGACTTCACCGCGAGGGTCGACTTCACCGCGCACCAGGACCGCGAGGGACATCAGGGACAACTTGTTATCACCAAGAAAGAGTTTGcccacaataaatatttatttaatttcaagaaACCAGACACAGACGATGCTGTGGACGTCCAAGGGTCTGAATCGACTACAACAGAGAAGCCAACGGAAGCTATCGGTTCCTTACCTGACCTGAATCCAACACCACTGGTTGAAGAATTGAGTTCGACTGAAGATTTCTTGAAGATGCCAGACTTGGCGCCCGCTGATAATATTGAAGTTACGGACCCGGAAGCAGCGGCAGCAACGGAAGTGAGTGACAAAGAAGAATCCGGATCTCCGAGTAAATCCAAGAAGTTAAAGTGTCCACATTGCGACAAGAGATATAGCAGTAAACAGAGCAAGTCACTGCATATTAAGGCGGTGCACAAGGGCGAGCGTGCGTACATCTGCAGCGAGTGCGGCGCCGCGTTCGCGTACCCGCGCGCGCTGGCGCTGCACACGCTCGCACACGCGCGCCGCAAGCCCGCCAGGGGCTTCGCCTGCGACCTCTGCGGGAAGGTATTAAACCATCCTTCGTCGGTGGCATACCACAAGGAAGCAGAGCACGCAAACCAGCGCTACGTCTGCAACAAGTGCAACAAGTCCTTCAAACACAAGCAGCTGTTGCAGCGGCACCAGCTGGTGCACTCACAACACCGCCCTTACGCATGCAAGACTTGCGGCGCTAAATTCAAGACGAAAGCAAACCTAATAAACCACCAGCTGCTTCACTCCGGCATAAAGAAGTTCCAGTGTGAGATCTGCAAGCAGAGGTTCGCGCACAAGACTAGTCTCACCCTACACAACAGGTGGCACAATGGTCAGAAGCCGTACGTGTGCAAGATATGCGGCAAAGCGTTCAGCCAGAAGGGCAACTTGTCGGAACACCTGCGTATCCACACAGGGGAGAAGCCTTACCGCTGCGTGCACTGCTCCAGGCGGTTTACTACCTCGTCGCAACACCGGCTGCATCTGAGAAGACAtatGGTGGGCGGCAGCTTGACACAACCAGAAACAGAAATCGAAGTGTCCCTCAGCGACCCGCTGTACATAGAAACGAGCGAAGACGGCGGCGAAGCGGCGAGCGAAGTTACCCTCCCAGAAGTGACAGTGAGCGAAGCGCAGGCGAAGTTTCCCTGCGACTTGTGCGGAAGTGTGCTGGCTTCGGACCGCGCTTTGATAAGACATAAGAAGAGACATTCACAACCGCTGCTACATTGTCCGTTTTGTCCGAAGACGTTCATTGATGCTTCTAACCTTAATAAGCATAAGAAGCAAGTCCACAAACAGTCGGCCGGACCGATCAGCCTCAGCCTGCTAGCTCCCCAACACATCCCCGACCACATCGAGATCATCGAGGGGGAGGCCGACGGGGAGTACACCGTCGTGGAGCAACTCTccggggagggggagggggagttGGAGGATGGGAACAAGGGGGAGGAGCGCGTCATATACGTCACGTACGAGGTGGACGACGAGCATGAGGCGGACCCAGCTTACCAGATCGTAGATCCTACTGAACAGGAGCCGACGTTAGAAATAGTTCGCGAAAAGTTGTTCGCACACGGTGTGGGCGGCGCGGCCGGCGGCGGCGTGCTACTGCAGCAACCCAAGCTTATCGACACGCTCGTTCACCATGACATACCGatgggaaAAAACGAATTGAAGAAGCAGGGAAGCCGGCAAAGCGATTTTGAAGACGCAGAGGCGAGTTTTAACGGAAAAACTGGTAACATGAATCTACAATATGCCGACGAATTAATTGAGAAGTTTAGCGGACGCGATAGAACATATACGGCGGCACGTTGGGTGCAAGAAGTTGAAGAGAACGCGACGATCTTTGGATGGAGCCCTTTACAGCAACTCATCGTGGCGCGAAGATCACTGATTGGCACGGCGGCACTCTGGTTGCGATCAGAAAAACCATGTAAGTCTTGGGAAGAGCTGAAGACGGGATTGTTAAGAGAATTTCCAGACACAATTGACCAGAAAGGAGTCCACGAGATGATGAGCGCACGACGCAAGAAACCCGGCGAGTCATGCCAAGATTATTTACTCATTATGAAGGAGCTTGGCAAACGTGGCAAACTACCAGATTACGTGgccattaaatatattattgaggGCATCACCGACGACGAggcgaacaaaattatgttgtacGGAGTGTCAACATACCCGGAGCTGAAGGAGAAACTCAAGATCTATGAAGTATTTAAGGAAAAGACACGAAGGAACCCTAGAGTGAGTAATATTAACAGTACGACCAGTaggtcaaataataattcagcGGGTCCTATAACTAGAACTATATCAAGCCTAAAGAGGTGTTACAATTGTGGCGAGCAAGACCATTTGGCATCAGCATGTCGACGAGGACTGAAATGTTTTAAGTGTAACGAGTACGGGCACATCGCTACAAATTGGAGAGCAGGCGCTGAGAGTGTTAGACGACGGAGTGACCACATCGAGCAGCCACAAGGAGAACAACAGATGACAGCGGCGAGCAAGCGAGTATTTACTACGAGCACAGAGCGGACAGCTACAGAAGAAACAAACATCGACAGCAAGAACATCAACGTCACATGCCAAAGTGACAGTAACACCAATGACATATCAGACTCATTGAAAAccgtaaaatttgtttataataatctcATTTTGCAATGTAAAGCGTTAATTGATACAGGTAGCTCCATTAACATAGTAAATTATGATGTATATTTAAAGTTGAACAGTCCGAAATTCATACCAAGcaaaagtttaataattcgAGGTGTGGGAGGAGGTAAATCAATCCCCCTAGGTttgataaagttaaattttgaagtagacAACCAATATTTTGATAACGTACCTTTCTATGTAGTGAAAAATGAAGCGATACCATACCAAACAATACTAGATTCAGTGTTTTTATccaaagtgtgtttgtttgtgaaagatggctgtgtgaaaataactcaaaaagATGATTGGATGAATTGTATTGAGTGTTTTGCTACTAATGATGATTTTGCAGGATTTATCGGTGACAGTAAGTACAAAGAGCAAGTGATTGAGTTGACGCGGAGTTATCAGCACCAAAGTCCATTGAAGGAAGCCCCAATTCaactgaaaataatacttagagATGAAAAGCCAATTGCACAACGTCCAAGACATCTGTCTTTATTTGAGCAAGGTAAAGTCGAAGAACAGGTGAATGAGTGGTTACAAGATGGAATTATCAGGGTGAGTTACTCAGAATTTGCTAGTCCATTGGTATTAGTTAAGAAAAAGGATGGAGGTATCCGAGTTTGTGTGGATTACCGATTACTGAACAAACAGATGCTGAAAGATGAATACCCATTACCCATTATCTCTGATCTTATTGATAAGCTGCAGGATGCTAGTGTATACAGCGTGTTAGACTTAAAGGCTGGATTTTTTCACTTGAAGGTTGAGGAAGCTTCTATTAAGTATACTGCCTTTGTTACTCATCACGGacagtttgaatttttgagAGCCCCATTTGGATTGATGAATTCTCCCAAATATTTCATGAGATTTGTGTCTATTATCTTTAGAGAGCTTATCGCACAGGGTATTGTAGTAATATTCATCGATGATATTTTGATTCCAGCGCAAACAGCTATGCAAGCTTTGGACAGGTTAAAGCTAGTACTAGATGTCTCTGCCGAGTATGGATTGAATTTCAACTGGAATAAGGCACGGTTACTGTGTGAAGAAGTTGAGTACCTGGGCCATGTGATAAGAAAAGGCGAGGTAAGGCCGTCTAAGGATAAAGTTTCTGCAGTTGCAAGATACCCAGAACCGAAGAATTTGAAGCAGTTGCGCAGTTTCGTAGGATTAGCGTCGTATTTTAGAAAGTAtgtacaaaattattcatttatagcTAGACCTTTGACCGATCTATTGAAAAAAGATTGTAAATTTGAGTTTGGAGAAAAAGAAAGAGTAGCATTTAATCAACTGAAGCAGATTTTGATAGAAAACCCAGTATTAAAGATATACAATCCTAAATTAAGGACTGAGTTACACACGGATGCCTCTAGTATAGGAATAGCAGGCATATTGATGCAACATCATGAAGATGGCTTACATCCAGTATATTACCTAAGTAAGCGTACCACTGAAGCAGAAAGTAAGTATTCAAGTTATGAATTAGAAGCGTTAGCTATTATAGAAGCAGTAAGAAAATTCAGACACTATTTGTTCGGAATTAAGTTCAAAATAGTTACAGATTGTCAAGCATTtgagttaacattaaaaaagaaagatttatgcACAAGAGTTGCAAGGTGGGTGTTACTGCTCAGCGAATATGATTTTATAGTCGAGCACCGATCAGGAGAGAAGATGAGACATGCAGACGCACTCAGCCGAGCACCATACATAGCGGTAATAAGCAGCTTTATAGACCAAGTAGGAATTGCacagaagaaagatgacggtttAGCAGCAATTATGGCGATTTTGAAGGATACAAGGTTTGAAGACTATTACCTGGACAATGGACTGTTGTATAAAGGTGAGGATAAACGGTTAGTTGTACCTAAAATTATGGAAGGAGATATTTTGAGGATGGCGCATGAGAAGGGACACTTTTCTAAGAAGAAGATGATGGATATTATTGGTAAGGATTATTTCATACCAGACCTTAACAGGAAGATTGATAATTTTGTGCAGGGATGCATACCTTGTTTGTTAGCAACACGGAAGGCGGGAAAGCAGGAAGGATGGTTGAATACTATAGAAAAAGATGATACACCTTTACATACTATTCATGTGGACCATATTGGACCTATGATGGAgactaaaaagttatataactatattctaacgatGGTAGATGCATTTACTAAATATGTTTGGTTATTTCCAGTTAAGAGTACtacaagtaaagagacattgagTAAAATTGCCACACATCAACAAGCTTTTGGAAACCCTAATCGATTTATAACTGATAGAGGTTCAGCTTTCACCAGCAACGAGTTTAAGGAGTACTGTGTGACAGAAAATATTGAGCATTGCTTAATTACGACGGGAATTCCCAGAGGAAATGGACAAGTAGAGAGGATCCATAGAATTTTGATAGCAGTTTTAACTAAGCTTTGTATTTCAGAACCTGGATGTTGGTATAAACATGTGAGTAAAGTACAGAGGGCGCTTAACAGTACCTATCAAAGAAGCATCAACACAACACCATTTCAACTGTTAGTGGGCGTGAGAATGAGAACTAAAGAAGATCTGGAAGTGCATAAGTTAATATCACAGGAAGTCAGAGGTTGTTTCAGTGAAGAGAGAGAAAACTTGAGAATCGAAGCTAAAGAGAGCATACTGAGGGTGCAGGAGGAAAATCAGAGAGAATATAACAAGAAAAGAAAGGAAAGCACTAAGTATAAGGAGGGAGACTTGGTGGCCATTCAACGTACACAGTTTGGTGGAGGTCTGAAGTTGAAACCGAAGTTCCTGGGACCCTATAAGGTGACAAAAGTCAAGCGCAACGATCGTTATGAGGTGGAGAAGCTAAATCCGTACGACGAAGGCCCTGGAAAGACGTCCAGTGCTGCAGATCACATGAAACGTTGGCCGGAGGAGcagCGTGTGACAGACGAGCAAGGGAACCCACTTCACTTCACGATGCAGGACGGCACGCAGCTAGCTATCACTTCCTTAGATGGACACTCTTTGCATGTAATAACTCAAGATGGGCAGACGATACCAGTAGAGATCAACCACCTAACAGAACAGGTAAGTTAG
Protein Sequence
MEVFLYNSTVCRLCGEENDNGTFLYSSEDNPQNISDLVNAYLPIKVSDDGQLPRTICPGCTIQLEATVEFINLIINGQKAIRSLYQREKEYKKNILKTTEDEEVSIENGTQEVLKSPVYTEEHPASLQVAGLDKPKRKRGRPPKKHKTPEELAQEAAAKQEEIKVVEEVKNEEPTGKRKRRHPERFKEVVQGKELEKIFLEEGVIDKEENDQEVQQEKEDVKPVVPKVPEVIGHTESGELVVVVKGKGRGRPKGRLRVTREKCAICGKEFSCVGRYMSHVAGHGPVLYRCAAPACGRDFTARVDFTAHQDREGHQGQLVITKKEFAHNKYLFNFKKPDTDDAVDVQGSESTTTEKPTEAIGSLPDLNPTPLVEELSSTEDFLKMPDLAPADNIEVTDPEAAAATEVSDKEESGSPSKSKKLKCPHCDKRYSSKQSKSLHIKAVHKGERAYICSECGAAFAYPRALALHTLAHARRKPARGFACDLCGKVLNHPSSVAYHKEAEHANQRYVCNKCNKSFKHKQLLQRHQLVHSQHRPYACKTCGAKFKTKANLINHQLLHSGIKKFQCEICKQRFAHKTSLTLHNRWHNGQKPYVCKICGKAFSQKGNLSEHLRIHTGEKPYRCVHCSRRFTTSSQHRLHLRRHMVGGSLTQPETEIEVSLSDPLYIETSEDGGEAASEVTLPEVTVSEAQAKFPCDLCGSVLASDRALIRHKKRHSQPLLHCPFCPKTFIDASNLNKHKKQVHKQSAGPISLSLLAPQHIPDHIEIIEGEADGEYTVVEQLSGEGEGELEDGNKGEERVIYVTYEVDDEHEADPAYQIVDPTEQEPTLEIVREKLFAHGVGGAAGGGVLLQQPKLIDTLVHHDIPMGKNELKKQGSRQSDFEDAEASFNGKTGNMNLQYADELIEKFSGRDRTYTAARWVQEVEENATIFGWSPLQQLIVARRSLIGTAALWLRSEKPCKSWEELKTGLLREFPDTIDQKGVHEMMSARRKKPGESCQDYLLIMKELGKRGKLPDYVAIKYIIEGITDDEANKIMLYGVSTYPELKEKLKIYEVFKEKTRRNPRVSNINSTTSRSNNNSAGPITRTISSLKRCYNCGEQDHLASACRRGLKCFKCNEYGHIATNWRAGAESVRRRSDHIEQPQGEQQMTAASKRVFTTSTERTATEETNIDSKNINVTCQSDSNTNDISDSLKTVKFVYNNLILQCKALIDTGSSINIVNYDVYLKLNSPKFIPSKSLIIRGVGGGKSIPLGLIKLNFEVDNQYFDNVPFYVVKNEAIPYQTILDSVFLSKVCLFVKDGCVKITQKDDWMNCIECFATNDDFAGFIGDSKYKEQVIELTRSYQHQSPLKEAPIQLKIILRDEKPIAQRPRHLSLFEQGKVEEQVNEWLQDGIIRVSYSEFASPLVLVKKKDGGIRVCVDYRLLNKQMLKDEYPLPIISDLIDKLQDASVYSVLDLKAGFFHLKVEEASIKYTAFVTHHGQFEFLRAPFGLMNSPKYFMRFVSIIFRELIAQGIVVIFIDDILIPAQTAMQALDRLKLVLDVSAEYGLNFNWNKARLLCEEVEYLGHVIRKGEVRPSKDKVSAVARYPEPKNLKQLRSFVGLASYFRKYVQNYSFIARPLTDLLKKDCKFEFGEKERVAFNQLKQILIENPVLKIYNPKLRTELHTDASSIGIAGILMQHHEDGLHPVYYLSKRTTEAESKYSSYELEALAIIEAVRKFRHYLFGIKFKIVTDCQAFELTLKKKDLCTRVARWVLLLSEYDFIVEHRSGEKMRHADALSRAPYIAVISSFIDQVGIAQKKDDGLAAIMAILKDTRFEDYYLDNGLLYKGEDKRLVVPKIMEGDILRMAHEKGHFSKKKMMDIIGKDYFIPDLNRKIDNFVQGCIPCLLATRKAGKQEGWLNTIEKDDTPLHTIHVDHIGPMMETKKLYNYILTMVDAFTKYVWLFPVKSTTSKETLSKIATHQQAFGNPNRFITDRGSAFTSNEFKEYCVTENIEHCLITTGIPRGNGQVERIHRILIAVLTKLCISEPGCWYKHVSKVQRALNSTYQRSINTTPFQLLVGVRMRTKEDLEVHKLISQEVRGCFSEERENLRIEAKESILRVQEENQREYNKKRKESTKYKEGDLVAIQRTQFGGGLKLKPKFLGPYKVTKVKRNDRYEVEKLNPYDEGPGKTSSAADHMKRWPEEQRVTDEQGNPLHFTMQDGTQLAITSLDGHSLHVITQDGQTIPVEINHLTEQVS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-