Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.0039 0.31 12.2 2.9 1 22 146 167 146 167 0.95

2 6 1.6e-05 0.0013 19.7 0.6 1 23 176 198 176 198 0.97

3 6 0.1 7.9 7.8 4.8 3 23 210 229 209 229 0.98

4 6 8e-07 6.3e-05 23.8 2.2 1 23 235 257 235 257 0.97

5 6 1.1e-06 9e-05 23.3 1.7 1 23 263 285 263 285 0.96

6 6 1.8e-07 1.4e-05 25.8 1.3 1 23 291 313 291 313 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.0039	0.31	12.2	2.9	1	22	146	167	146	167	0.95
2	6	1.6e-05	0.0013	19.7	0.6	1	23	176	198	176	198	0.97
3	6	0.1	7.9	7.8	4.8	3	23	210	229	209	229	0.98
4	6	8e-07	6.3e-05	23.8	2.2	1	23	235	257	235	257	0.97
5	6	1.1e-06	9e-05	23.3	1.7	1	23	263	285	263	285	0.96
6	6	1.8e-07	1.4e-05	25.8	1.3	1	23	291	313	291	313	0.98

Coding Sequence: ATGCAGAACAACCCCCAGGAGCTCTCATGGCAGGCGATTCAAGCGATAGTCGGGGTAAAACTTCCCTCTTCTGTGTTACGTTTCGACGACATCGAGTTCGATGTCGACGAATCAGATTCGGACGTCGAAATTGTAGAAAACGAAAGTGAATCCGATAATAACGTCTCATCTCGCCCTGAATACTCTGACAATGAAAAAATAGCATCGCCTGAGAGAGAACTGAGCGAGTCGCCTGTTCTACATCTCGTCGAGCCGGACAATAACAATTCAGATAAAGATTCTTTAGATTATAGAGAATTCCTGGATAAAGTAGGCAATAAAGATAACACCGAGAAGAATATAATACAGATGGACGACGCGGATAGTTCTAATGGGAACGTGATGTCGATCGAGAACTATTTGGAAGTAACTCTATCTACGGACCCCGAGGCTAGTCATACATGCAGCCGCTGCAATCAGATGTTCACCAGTGAGCAGTTACTGGCGTCGCACCAGTGCACCGCTAAACCCACCGAAGAAAGGAAGTACCCATGTCATGTATGTACAGAGAAATTTCCCAGTTACTGGGAGCTAAGGAAACATATCAACGGCCACTTCCCTGGCATGTTGGATTCCAAATCCAGCTTCTGTCATCTCTGTCAAAAGGATTACACCAAAACAGGTTTCATGAACCATTTACGTAAACACACAGGAGAGCGACCTTTTGTCTGTGAACTTTGTCACAAAGCTTTCTCCCAGTCAAGTTCATTGTCGATCCACATGAAGTTCCACCTGAACGTACGTAAACATGCGTGCACAGTGTGTGAGAAGAAGTTTGTTACTAAAAGTGAATTATCTCGTCACATGACTGTTCATACTAAACAGAAGTCATACTACTGTGGGGTCTGCGACAAAGCCTTCACACGGTCTGATAACATGAAGAAACATGAAAAAACTCATGGCTGA
Protein Sequence: MQNNPQELSWQAIQAIVGVKLPSSVLRFDDIEFDVDESDSDVEIVENESESDNNVSSRPEYSDNEKIASPERELSESPVLHLVEPDNNNSDKDSLDYREFLDKVGNKDNTEKNIIQMDDADSSNGNVMSIENYLEVTLSTDPEASHTCSRCNQMFTSEQLLASHQCTAKPTEERKYPCHVCTEKFPSYWELRKHINGHFPGMLDSKSSFCHLCQKDYTKTGFMNHLRKHTGERPFVCELCHKAFSQSSSLSIHMKFHLNVRKHACTVCEKKFVTKSELSRHMTVHTKQKSYYCGVCDKAFTRSDNMKKHEKTHG

Sequence clustering based on sequence similarity using MMseqs2