Basic Information

Transcription Factor Domain

TF Family: AP-2
Domain: TF_AP-2 domain
PFAM: PF03299
TF Group: Basic Domians group
Description: Activator protein-2 (AP-2) transcription factors constitute a family of closely related and evolutionarily conserved proteins that bind to the DNA consensus sequence GCCNNNGGC and stimulate target gene transcription [PMID: 2010091, PMID: 1998122]. Four different isoforms of AP-2 have been identified in mammals, termed AP-2 alpha, beta, gamma and delta. Each family member shares a common structure, possessing a proline/glutamine-rich domain in the N-terminal region, which is responsible for transcriptional activation [PMID: 2010091], and a helix-span-helix domain in the C-terminal region, which mediates dimerisation and site-specific DNA binding [PMID: 199812]. http://www.ebi.ac.uk/interpro/entry/IPR013854
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 9 0.0028 61 4.6 0.1 21 45 38 62 27 63 0.85

2 9 0.0019 41 5.2 0.3 21 45 57 81 56 82 0.84

3 9 0.0011 23 6.0 0.2 21 46 76 101 75 103 0.87

4 9 0.0046 1e+02 3.9 0.2 21 45 95 119 94 120 0.84

5 9 0.0013 28 5.7 0.2 21 46 114 139 113 143 0.87

6 9 0.051 1.1e+03 0.5 0.0 21 37 133 149 132 151 0.93

7 9 0.0016 36 5.4 0.1 21 46 152 177 149 183 0.88

8 9 0.05 1.1e+03 0.6 0.0 21 37 171 187 169 189 0.93

9 9 0.0013 28 5.8 0.1 21 45 190 214 188 217 0.86

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	9	0.0028	61	4.6	0.1	21	45	38	62	27	63	0.85
2	9	0.0019	41	5.2	0.3	21	45	57	81	56	82	0.84
3	9	0.0011	23	6.0	0.2	21	46	76	101	75	103	0.87
4	9	0.0046	1e+02	3.9	0.2	21	45	95	119	94	120	0.84
5	9	0.0013	28	5.7	0.2	21	46	114	139	113	143	0.87
6	9	0.051	1.1e+03	0.5	0.0	21	37	133	149	132	151	0.93
7	9	0.0016	36	5.4	0.1	21	46	152	177	149	183	0.88
8	9	0.05	1.1e+03	0.6	0.0	21	37	171	187	169	189	0.93
9	9	0.0013	28	5.8	0.1	21	45	190	214	188	217	0.86

Coding Sequence: atgtttgatgaaaattcCCCACGTTCCATGTACCCCAACTGgaGGTTTCAAGGTTCCGAAGAAGATTCGATAAAGTTACAGAGCGCGACGAAGTTGCAGAGCTTCAAAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGTGCTCCAAAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAAAGAAGCTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAAAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGTGCTTCAGAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGTGCTCCAAAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAAAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGATCTCCAAAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGTGCTCCAAAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAAAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTCCAAAGAAGTTGCAGATCTCCAGAGAAGTTGCAGTGCTCCAAAGAAGTTGCAGAGCTCCAGAGAAGTTGCAGAGCTTCAAAGAAGTTGCAGAGCTCCTAAGAAGTTGCAGAGCTACTAA
Protein Sequence: MFDENSPRSMYPNWRFQGSEEDSIKLQSATKLQSFKEVAELQRSCRAPEKLQCSKEVAELQRSCRAPEKLQSSREVAELQRSCRAPEKLQSSKEVAELQRSCSASEKLQSSREVAELQRSCRAPEKLQSSREVAELQRSCSAPKKLQSSREVAELQRSCRAPEKLQISKEVAELQRSCSAPKKLQSSREVAELQRSCRAPEKLQSSKEVADLQRSCSAPKKLQSSREVAELQRSCRAPKKLQSY

Sequence clustering based on sequence similarity using MMseqs2