Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 0.0053 0.38 11.4 6.0 2 23 206 227 205 227 0.96

2 5 0.00033 0.024 15.1 1.4 1 23 233 255 233 255 0.92

3 5 0.0002 0.014 15.9 1.1 1 23 261 284 261 284 0.96

4 5 5.2e-05 0.0037 17.7 3.6 1 21 290 310 290 312 0.95

5 5 0.00059 0.042 14.4 3.4 1 23 318 342 318 342 0.91

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	0.0053	0.38	11.4	6.0	2	23	206	227	205	227	0.96
2	5	0.00033	0.024	15.1	1.4	1	23	233	255	233	255	0.92
3	5	0.0002	0.014	15.9	1.1	1	23	261	284	261	284	0.96
4	5	5.2e-05	0.0037	17.7	3.6	1	21	290	310	290	312	0.95
5	5	0.00059	0.042	14.4	3.4	1	23	318	342	318	342	0.91

Coding Sequence: ATGCCTGCTCAGTGTCGAACCTGTGGCAAGATAATTTACTGCCTAACCGCAACCAATCTGTTTAAGCAGCCAGAAAGAATTATGCTGCACCAAATAGAGGCACTAACCGGGCTTTTTTTAATTGAGCAAACAACGTTTCCGACACAAATCTGCGGACCCTGCGAATTCGCGCTACGTCAAGCAATATTATTTCGTGAGCGCACGATAAaaacgcagcagctgctgatcaACAAACACATTGAAAAGAACGAGCAGCCAAAGGAAGTTGTTGAGGCAGATTCACAGCTGGTGGAATACGAGGAGAACGCAACGGAATTGTACACCTCCTAcgaggagctggagctgaCGCAATCCGACAAGGAGGAGCAGGGCAATGAGCTGCAGACAAACAGCGAAGCAgaagaaacaacaaatgcaacacaGCAGCCAAAAAATGAAGAGTTGGAAGAATCTTCGATTCCAACTGAAGAATCCGCCTCGGAGCAATCTTCCTCCCAGGTCAGCACCCGGATGAACTTTGCCGCCACCAGGAGATACGCGCCACGCATCAACTGGAGTCGTCTGTCGGAGGATGAAATCGTCGAGATGAAGCGGGCGCGTCGCAAGCGAGACTGCATCTGTGAGCTGTGTGGCAGGCACTTCACCTGCCCCAGCAACTTCAAGGTGCACCTGCTGAGGCACACGGGCGTCAAGAACTACGCCTGCCAGCAGTGCCCCATGAAGTTCTACACGCCGCATCTCCTACGCAGGCATGAGTTTGCACATCTCTGCGAGAAGCCCTATCCCTGCCAGTACTGCGGACAGACCTTTGCGGATCACAGCGGACGCATTCAACACGAACGGAACCGTCACACGAACTACAAGCCCTACAAGTGCACCAATTGCGACAAATCCTTCGCGGTCAGCAACAAGCTCAAGACGCACATGCTCTGCCATTCGGGAGTGCGCACCTTCCACTGTGACGTATGCAAGGTATCCTTCATGCGACGTTCTCATCTGGTGGCCCACTTTCGATCCAAGGGGCACGAACAAAGCGTACAAAACAATGCTGCAAAGACCGATATTGATAATGTAGTTTAA
Protein Sequence: MPAQCRTCGKIIYCLTATNLFKQPERIMLHQIEALTGLFLIEQTTFPTQICGPCEFALRQAILFRERTIKTQQLLINKHIEKNEQPKEVVEADSQLVEYEENATELYTSYEELELTQSDKEEQGNELQTNSEAEETTNATQQPKNEELEESSIPTEESASEQSSSQVSTRMNFAATRRYAPRINWSRLSEDEIVEMKRARRKRDCICELCGRHFTCPSNFKVHLLRHTGVKNYACQQCPMKFYTPHLLRRHEFAHLCEKPYPCQYCGQTFADHSGRIQHERNRHTNYKPYKCTNCDKSFAVSNKLKTHMLCHSGVRTFHCDVCKVSFMRRSHLVAHFRSKGHEQSVQNNAAKTDIDNVV

Sequence clustering based on sequence similarity using MMseqs2