Basic Information

Gene Symbol
-
Assembly
GCA_951799385.1
Location
OX637330.1:7401635-7418058[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 14 7.4 6.8e+02 2.0 1.9 1 23 204 227 204 227 0.92
2 14 0.027 2.5 9.7 0.3 2 23 318 340 317 340 0.91
3 14 0.0055 0.51 11.9 0.2 2 20 378 396 377 398 0.94
4 14 8.7 8.1e+02 1.8 3.0 1 23 403 425 403 425 0.96
5 14 1.8 1.6e+02 4.0 2.0 1 20 747 765 747 767 0.79
6 14 1.5 1.4e+02 4.2 2.6 1 23 779 801 779 801 0.95
7 14 0.035 3.3 9.3 0.7 2 23 807 828 806 828 0.95
8 14 1.8 1.7e+02 3.9 2.1 1 10 851 860 851 872 0.71
9 14 0.0055 0.51 11.8 0.2 2 23 949 970 948 970 0.96
10 14 6.1e-07 5.7e-05 24.3 2.7 1 23 976 998 976 998 0.99
11 14 8.7e-05 0.0081 17.5 0.6 3 23 1005 1025 1003 1025 0.96
12 14 0.00069 0.064 14.7 1.5 2 23 1032 1054 1031 1054 0.96
13 14 0.56 52 5.5 0.2 1 20 1061 1080 1061 1080 0.92
14 14 0.0045 0.42 12.1 0.7 3 23 1093 1114 1092 1114 0.95

Sequence Information

Coding Sequence
ATGGCGGACACATCCAGAAAAAGGTCGAGAAAGTCGAAATTAGTGCCTAGAGACTGTGTCGCTGACGAAGATGATCTTGAATTGCAGATTCCAGCACAGAAAATATGTAAAAGCGGGAAACAGTCTACCAAAAGACAAGTAACGAAAAAGGTTATAGTACAACTAGAGCCAACCATTTCAAAAACAGAAGAAGCTTGCAACACGAGTgtcctaaaaaaaattaacgcatcatcatcatctaaaCAAGATAATGAGCCCCAAAATATTGGCGATAACCCCAGTATATCgccaagaaaatttgaaattgacATCGAAGTGGAGTCTTGCGATGACGAACAATTCGCAGGGTTTGGTGACGACGATAAACTACAAACGACTCCTATCCAACTCTCTCTTGAAACTATACTCAATGCTGCCGACAATATAGTCCAGAATTCAACGGACGTTGCTGATCAAATTCTCAACGTATACGTTAGGAATACCATAGGATATGAAGACGTTAACAAACAGAATCAGCTAGTAGAACAACAAGAGAAACTGATACAACAAAGTATAGATGAATGGCGCACGTGGCAGTTCCGTAGTTTCCATAGAGAAAACCCTTTATTCTACAAATGCTACATCTGTTTAAAATCCTGGTGGCACCTAACGGAGTTCCGTAACCATATGTCTTCTGAACATAGTGATGATTCACTGGTTATAATTGCTTTAGAGAGATATGAATTGCATGAAGCGAATGTGGTGGCATTCCACGAAAGGATGCTACTAGATATATACACCGAAGGCCCTTGCTACCGATGTGGGAAGGACTATGCAGCTCATACCCTCGATTACAGGTTTCAAAAGAAATTTTACAAGAACGAAGGCTGTACAAAACAGTTTTTGAGCTGCAAGGGTCTAAGAGACCACTGCTTCAGCTGTCCTGTCTGCGAAGAGCAggacaaaactataaaatgtgATGTATGTAAGTCcagatttgaaaaaaaagagGAATTGAATGATCATTTAGTATTGTCTCATTTGGTACGGTCAGATATACCGATAATGACAAAGTATAAGAAATGCAAGATTTGTGCAGAACGATATACCTGTGATTTTTTGCATAAGTGTAGGCAAAAGGGAGCACTTTCTGAATGTCCACACTGTTTACGGAGCTTCTCAAATGTTGTGTCTTTACAGATGCATTTAGAACAGTCCGATGAACCATATAAATGTGAAGTTTGTCGGATTGTCATGACATATAGCTGTAAAAAATATGAACACATGTTGACACACACCGACAAGTATTTGATTGTACGGAAATGTGTGGCATGTGAGGGTTTGAAGGTGTTTTTAAATGATGAAGATGCAGTCGGACACTGGTTGTTGAAACATGAGTGGGAAACGAAATGTCCAACCTTTTTTCCTAAGATGATAGTACCATCGTCCTGCCTGTATAACAGTTTAGCAAAATCAGAATCGATTGAAGAAGAATCAGTGTTGGAAGAAAAAGAATCCGTACCTGACGGACAAGAATCCATACCAGATGAAGAAGAATCCATACCGAACGAAGAAGAATCTATACCGGATGAAGAAGAATCCATACCGAACGAAGAAGAATCTATACCGGAAGAAGAAGAATCCATAAAGATCGAAGAAGAATCCATACCAGACGAAAAAGAATCCATAAAGATCGAAGTAGAATCCGCATTGAATGAAGAAGAATTCTTGCCAGAAGAAGAATTGATATCAAAAAGTCGAAGAAAATCGGCTTTTATGTGTGAACGGAAATTGTTAGAAGCAAAACTAGAATCGGCAACAGAATTTTTATTTGGAACAGTTGCAGttaaagAAGAGCCAGTAGATTCAGAAGATAACCCACAAATCATTATCAAAGAAGAACCGTTAGAAGAATTTGCAATGCATGTAGAAGAGAATCTAACAGAGAATTTTGAACATGAAGTATGTATCAAAGAGGAATGTGTGGTAGAAGAGTACGAGGATTATGAAGGAGACATTATCAAATTGAACTTCAATATAGAAGACATATTATCGAAAGAAAAATGTATTGAAGATGATGACAATTGTTCTTTAGAACAAACAGAAGAGAATCGcgaagtcagtcagtcagaagaGAATCGAGAAGCCAGTCAGTCAGAAGACGATGCTGATTATACAGAAGAATCCCAGCAATCACAAGAGAGCTTGCAAGAACCAGAAGTTGCCATAAAACGTGGGGATAAAAGGaacaaaaaattatacaaatgtACTAAATGCGGATTCACAGCAAAGCATAGACAATATAGAAATCACATAGAATACGACTGCGGTTCTAACCTAGTGAAGCATAAAACCTACATATGCACGAAATGTGATAATAAATATGTGTCTATGAAAAAGTATTTGACCCATTTTAAAGAACACGGATACAAACATCTCTCATGTCCTGATTGCTTGAAGGACTTTGATACGTTTACAAATCTGGGTCAACATTTTACTCGACATATTAAACATAGTTTTATACGAGTTAAAATGATCACCCATGATGGTACTGCAATGGCTAAGCCCGACTATCAATGCAAGAAGTGTGGAAAAATCATagcttttcataatttttttgaacATTATGAATTGCATATCAACGCTCAGCCAACGCATCCTATTAAAGTTACATCGAGGCCAAGGCATAGGCACGGAGAATTGCATGAAACTATAATTAAAGAGTGTATTGCCCGCTTGAACAAACAGCCAAAAGAATGCAATCATTGCCATCGTTGGTTCAAACGAGTGAACGAATGTAAACGCCACATCATTGAACATCTGCTAACAGACGCATACAACCAGAAACACATTTACAACGAGCTCAAATGCCAAGTTTGTGAACAGGGCTTTGGTGTACCGGAGAAATATAAACAGCATATGCGTGACCATGCATCGTTGCCCGTCTACAAGTGTGAATTGTGTGACCGGACCTTCAGTGACTCGAGTAACTTTACCAAACATAAAAAAGTGCATAATTTGACAGTGATTATCTGTGATTTGTGCGGTAAAAAATTTCAGTCGAAATTGTCTTTGCAGAAACATATTGAGAAGCATCAAAGCACCGATCCAATTACTTGCAAGATTTGCGACAAGGTGTTTTACTTTGATACGTCGTACAGGCGCCACGTGAGATACTTTCACGACAAGACTGTGATCGGATTTCGCTGCGTTATCTGCAGCGAGCGATTCGACACCTTAAAACTCAAATGGGACCATATGTGGGAGgCACATAAGGAGAGAAAGCAGAAAGCAGACTGTCCAATATGCCATGCATCATTCAGGAAGTACTCAGATGTCCGTCTCCATGCTAGGTTAAACCATTTGACAGAAGTCTCCGTGTTGAATGTCAAAAAGAATGCGAGGAATCCCAATTTAGATATTGATAAGTATTTAAGTGACCCCGCTACCGTCAAAGTTGGGATGATGGAGACGCTGGTTATCTATGACTCTGATTGA
Protein Sequence
MADTSRKRSRKSKLVPRDCVADEDDLELQIPAQKICKSGKQSTKRQVTKKVIVQLEPTISKTEEACNTSVLKKINASSSSKQDNEPQNIGDNPSISPRKFEIDIEVESCDDEQFAGFGDDDKLQTTPIQLSLETILNAADNIVQNSTDVADQILNVYVRNTIGYEDVNKQNQLVEQQEKLIQQSIDEWRTWQFRSFHRENPLFYKCYICLKSWWHLTEFRNHMSSEHSDDSLVIIALERYELHEANVVAFHERMLLDIYTEGPCYRCGKDYAAHTLDYRFQKKFYKNEGCTKQFLSCKGLRDHCFSCPVCEEQDKTIKCDVCKSRFEKKEELNDHLVLSHLVRSDIPIMTKYKKCKICAERYTCDFLHKCRQKGALSECPHCLRSFSNVVSLQMHLEQSDEPYKCEVCRIVMTYSCKKYEHMLTHTDKYLIVRKCVACEGLKVFLNDEDAVGHWLLKHEWETKCPTFFPKMIVPSSCLYNSLAKSESIEEESVLEEKESVPDGQESIPDEEESIPNEEESIPDEEESIPNEEESIPEEEESIKIEEESIPDEKESIKIEVESALNEEEFLPEEELISKSRRKSAFMCERKLLEAKLESATEFLFGTVAVKEEPVDSEDNPQIIIKEEPLEEFAMHVEENLTENFEHEVCIKEECVVEEYEDYEGDIIKLNFNIEDILSKEKCIEDDDNCSLEQTEENREVSQSEENREASQSEDDADYTEESQQSQESLQEPEVAIKRGDKRNKKLYKCTKCGFTAKHRQYRNHIEYDCGSNLVKHKTYICTKCDNKYVSMKKYLTHFKEHGYKHLSCPDCLKDFDTFTNLGQHFTRHIKHSFIRVKMITHDGTAMAKPDYQCKKCGKIIAFHNFFEHYELHINAQPTHPIKVTSRPRHRHGELHETIIKECIARLNKQPKECNHCHRWFKRVNECKRHIIEHLLTDAYNQKHIYNELKCQVCEQGFGVPEKYKQHMRDHASLPVYKCELCDRTFSDSSNFTKHKKVHNLTVIICDLCGKKFQSKLSLQKHIEKHQSTDPITCKICDKVFYFDTSYRRHVRYFHDKTVIGFRCVICSERFDTLKLKWDHMWEAHKERKQKADCPICHASFRKYSDVRLHARLNHLTEVSVLNVKKNARNPNLDIDKYLSDPATVKVGMMETLVIYDSD

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-