Basic Information

Gene Symbol
-
Assembly
GCA_951799385.1
Location
OX637327.1:5884338-5888678[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 15 4.9e-05 0.0046 18.3 0.4 3 23 2 23 1 23 0.96
2 15 0.15 14 7.4 0.1 3 23 50 71 48 71 0.93
3 15 0.071 6.6 8.4 1.2 2 23 94 115 93 115 0.96
4 15 7.1e-07 6.6e-05 24.1 3.8 1 23 119 142 119 142 0.96
5 15 0.3 28 6.4 0.4 3 20 149 166 148 168 0.89
6 15 9.4 8.8e+02 1.7 0.0 1 13 175 187 175 189 0.88
7 15 3.7 3.4e+02 3.0 4.0 2 23 218 239 217 240 0.92
8 15 0.99 92 4.8 6.7 1 23 314 336 314 336 0.95
9 15 0.35 32 6.2 3.2 1 21 340 360 340 363 0.94
10 15 0.18 17 7.1 0.3 1 21 368 388 368 389 0.94
11 15 2 1.9e+02 3.8 2.5 3 23 397 419 396 419 0.86
12 15 0.00051 0.047 15.1 1.8 1 23 426 449 426 449 0.96
13 15 0.02 1.9 10.1 2.8 1 23 454 476 454 476 0.96
14 15 1.7e-05 0.0016 19.7 0.8 1 20 482 501 482 504 0.94
15 15 6.8e-05 0.0063 17.9 0.6 1 23 510 533 510 533 0.94

Sequence Information

Coding Sequence
ATGTGCGTATATTGCGGTGAAAGTTACACTGATGCCAACCTGTTTCGGCAACACATGAAGAAAGAACATTTCTCCTTCAAAGTCCGTACCGCTTTCGCACATATTGCCTACGAGTGCTACCTCAAAATCGACTGCACAGAAATGGCCTGCAGAATCTGCTTCGAATCCTTCGCAAGAATTGACGATATTGGACGACATTTAAATGAGAGACATGATGCCAAAATCAACTTTGACTTCCAATTAGGACTACATCCCTATAGATTCATACAAGACAGACTCATGTGCGGGATATGTGATCTAAACTTCCCTTGTATGCGACAGCTCAGTCGTCACATGTCTTCCCACTTTCAGAACTTCACGTGCGACACTTGCGGCAAGACTTACACGACGAACAGCTCCTTACAGCACCACATTCGATTCACGCACATAGCAGCGGAAAGAATATGCAGGAAATGTAAACAGACCTTCAGTTCTTTAGAAGCTAAGAGGGAGCATACAATAAATTCTCCAAAATGTTGGATGTATCAGTGCCTTGTGTGCCTTGAGCGATTCATGACATGGCCGGAACCACACTTATGGGCGAAAGAGAACGCGGAGATTGTGTTGCAATATTCGACCCTGTACCCATTCAGATTGCGAGGGAAAGCTATCACTTGCGTCTACTGCTGCGAAGGTTATGAGGACCCCACACATTTCAGAAGGCACTTCGACGTCCACCACCAAGAGTTCACCATCGGCACAGCATTCCACCACATGAGTAGCTTAAAAGAGTACCTTAAAGTCGATCTCTGCAACTTAAAATGCAGACTGTGTCTTCAACCTTGCGAGAAAATCGGTGATGTCGCACAACACTTGAAGGAGTCACATTCAGATGTTGCAAAGAAATTAAACCTCGAATTTGAAGTGGGTTTGCAACCTTACAAGTTGGTAAACAACAATTACTGCTGCTATCACTGCGGCAAGAAAATGCCCACCCTAATCAAGTTGTGTCGTCACACGATCTTGCATTACCAGCAGTTTACTTGCGACACTTGCGGTCGTAACTACCTCTCACACGAGGCTTTGAAGTACCATATTAAATGCATCCATGCAGTAACGAAACACGTGTGTAGGAAGTGCTGGAAAGAATACCCCACATTGGAGCAAAAGAAGGAACATGTTAGGGCATCAAAACCGTGCTGGACTTTCTGCTGCATCGTCTGCGGCGACAGATTCCAATCCTGGGAGCATAAACAGAAACATCTGCAAGCAGAACATGGATACGAAAAGATTGTCTATAGCTGTCCTGATTGCGAAGAAAAATTCAACTCGAGGAGGTATTTTTATACACATTATAAGCTCGCACATACTGATGAAGGATTCCAATGCCCTTGCTGTGGACAGAAGTTTAGTACTCAGAAACGGTTGGATGATCACTCCCGGGGACATACAGGAGAGAAACAGTTTGTTTGCACTATTTGCTCCAAGAGTTTCATGAGGCAGAACAGTCTAAAGCAGCATATGTGGATTCACAGCGAAAACAAGAGATTCGTCTGTATTCTGTGTGATAAGCAATTTGCACAAAAAATAAGCTTGAAGACTCATATGAAAACCATTCATCCTGATGTTTCTATTGATATTCAAGCAGGCTGCAATGCAACACAAATATCCTCCTTCGTCACTTAA
Protein Sequence
MCVYCGESYTDANLFRQHMKKEHFSFKVRTAFAHIAYECYLKIDCTEMACRICFESFARIDDIGRHLNERHDAKINFDFQLGLHPYRFIQDRLMCGICDLNFPCMRQLSRHMSSHFQNFTCDTCGKTYTTNSSLQHHIRFTHIAAERICRKCKQTFSSLEAKREHTINSPKCWMYQCLVCLERFMTWPEPHLWAKENAEIVLQYSTLYPFRLRGKAITCVYCCEGYEDPTHFRRHFDVHHQEFTIGTAFHHMSSLKEYLKVDLCNLKCRLCLQPCEKIGDVAQHLKESHSDVAKKLNLEFEVGLQPYKLVNNNYCCYHCGKKMPTLIKLCRHTILHYQQFTCDTCGRNYLSHEALKYHIKCIHAVTKHVCRKCWKEYPTLEQKKEHVRASKPCWTFCCIVCGDRFQSWEHKQKHLQAEHGYEKIVYSCPDCEEKFNSRRYFYTHYKLAHTDEGFQCPCCGQKFSTQKRLDDHSRGHTGEKQFVCTICSKSFMRQNSLKQHMWIHSENKRFVCILCDKQFAQKISLKTHMKTIHPDVSIDIQAGCNATQISSFVT

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00071853;
90% Identity
-
80% Identity
-