Basic Information

Gene Symbol
Rreb1
Assembly
GCA_013372445.1
Location
JABRWK010000037.1:620436-632235[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 16 5.2e-06 0.00044 20.5 1.3 1 23 71 93 71 93 0.99
2 16 9e-05 0.0076 16.6 0.4 1 23 107 129 107 129 0.98
3 16 2.4e-06 0.0002 21.6 4.2 1 23 135 157 135 157 0.99
4 16 3.3 2.8e+02 2.3 0.2 1 9 213 221 213 237 0.70
5 16 0.52 44 4.8 0.4 2 23 243 265 243 265 0.90
6 16 0.081 6.9 7.3 1.4 1 20 312 331 312 333 0.91
7 16 0.048 4 8.0 0.1 1 23 448 470 448 470 0.96
8 16 9.8e-06 0.00083 19.6 0.8 1 23 479 501 479 501 0.99
9 16 0.00055 0.047 14.1 3.1 1 23 507 530 507 530 0.97
10 16 0.00033 0.028 14.8 3.0 1 23 885 908 885 908 0.97
11 16 0.0016 0.13 12.7 0.5 2 23 1092 1113 1091 1113 0.97
12 16 0.083 7 7.3 6.3 1 23 1119 1142 1119 1142 0.97
13 16 0.082 7 7.3 3.5 1 20 1171 1191 1171 1195 0.95
14 16 0.29 25 5.5 1.3 1 23 1256 1279 1256 1279 0.95
15 16 0.0082 0.7 10.4 0.2 3 23 1328 1348 1326 1348 0.94
16 16 0.0049 0.42 11.1 5.9 1 23 1354 1376 1354 1376 0.98

Sequence Information

Coding Sequence
ATGCAAGGGGTGGTTTTTACACCTGGAAATCCCCAACAAGGTTCACCTCCCCCCAACAACGTCATGGcAACAAACATGGAAGAACCATTAGAGAATAATCAGAGCAACAACCAAATCGATtctggaattttttcaacgaCCGCCAACAGTTCAATTGATCAGACAAACGATAGTGATCATCGCAGCGATTGCAGTTCCCCGGAACGGAAATACGTGTGTCCGATTTGCGAGAAAATGCTTACCTCGCAACATAATTTTACCCTTCACATTCGATCGCACAACAACGAAAACGAGGAAATTAACAACGAAAAAGGTGGATTCACGTGTCGCATTTGCCAAAAAGTCTTGAGCTCTAGCTCAAGTTTGGATCGCCATGTTTTGGTGCACAGTGGTGAGCGGCCTTTTCAATGCAAATACTGTGGAGACACGTTCACGACAAATGGAAACATGCATCGACATATGCGCACTCATTCGAATAAAGGAGAGAATTATGAGTCTGATGGCAGTAGTGACAGTAGCAGTACCGTCAGGAGTATTGAAttcaacaataataaagtGGATACGAAGAAGGAAGTTAACAAACGTAAACTGGAAGATATGGACGAAGAGAGTAGCAACAAACGACGTGCGGAGTGCTTCAAATGTCCCGTATGCGAACGAACCGATTTTCACTCTTTGGTGGTTCTGGAGGCGCACTTGGAAGACAATCATCCAGAACATCCCGCGAAATGCAATGTTTGCAATCAggtatttcttaataacaaaCTTGTAATTGAGCACAAGGAAAAGGTCCACAACAACAAGTCCCACAAACAACAACCAGTAATGGGATTCGATGATCTTACATTTGTCGACTTTTCTAGTCGAAAGTTTCCACATATTGCAAGACGTGAATGTGAATTAAACATTCATAAATCCGCAGGAGGGTTGAAGTTTCAATGCTCTAAGTGTTCGAAGGCATTTCCTTGCTCAAATTCCTTGGAAATTcacgaaaaaaattgtcagGAGCCGCAAAACTTAACCGTGAACAAACCAAATGGCATATCAGAAGATGAAATTCGGAGAGCGGAATTTTTCTCTCGATTAAATCTTCAGGATAATTCTCCAGAAAAACAACATCCATTCAATTCAACTTTAAAACTCAAGGAACACTTGACCAGGGCGATGGATAGCACTAAAGATTTAGCTGATATTCAGTCAATTTTGTCCAATATCCAATGTCAAACTAGGCAAATTCCTTCATCTGCCAAACCTGCAGCAGAAAATGACAAACcggaaaatgaagaagaatcTCAAGACTCATTTGCCATTGAATTTAGGAAAATGAAGTTGCGTGGAGAATTTCCTTGTCGATTGTGTACAGCCGTATTTCCCAATTTACGCGCTCTCAAAGGTCACAATCGCGCTCATTTGAGTGGCAATACCAATGGTACTTATTATTGTAACATGTGTCCTCATTCGTCTATTGACAAGGCTGCACTAATTCGACATATGCGCACTCATAATGGCGATCGTCCTTACGAATGTTCTTTGTGTAATTATGCTTTTACCACTAAAGCCAACTGTGAAAGACATTTGAGAAATCGACATTCCAAGACAACGAGGGAGGAGgtgaaaaaatctattatttatcATCCATCTGAAGATCCTACCAATGAcgaattaaacaaattgacCATGAAAAGTGACGATAATAAGAAAGACGTTGATGCCGATAAAACCATCTTGCACTGTTCTACACCAAAATCAAcatcaaaaacgaaaaatgacGTTTCCTTTCCAACACCTACAATGGTTCCCGATTTACAGGCTTTGAAACCTTCCAAAATATATGCAGCAATGGACTTCGTCAGTCAGAACCACAAGGAAAATAGATTTCTTAACGGAGGCCATCCGTTTTTTTCGCagccatttaatttaatgcatAAAACTCCAGATGTAAAAATTCAGGTTAAACCTATAGACTCGCTTTGTGAAAATAGCTCGTTTGACCAATCGGAAGATGAATATTATGATGAAGAGGAGGAAGAACCGCCGATGGATGTCGCCTTAGATCTGAGCAAAAAGAAATCGGACGATGAAGTAAAGTCTCGAAACGATGATGATAACGAACCTCAAGACCTAACAAACAAAGCTAAAAATGCTACGCCAATGTTGCCGCTACCTCAAGTTTCCCCTAGTGTTAGTCAATTTCTTGCTCAACAATTTCTTAATACAAGTCAAGCGAAACTTGATCCAGCCGCCATTTATGCCACTCATCTGGCATACCTACATCGTTTTCCTGCTTGGCCTATGAATCCTTTATTGCTTCAAGCGTTGCCAGCTCTGCAACACCCAGCACAAGATATAAAAGAGAGAATGCAACGGCTACAGTTATGTGGCGGATCCGTGATAACTGATGAACTGAAACATTTAACAACACCGCCTCCGGTATCTTTACCACCCACTAATCAATGCCATGGCTTTGTTCAAAAACATGAAACAGAAGACAAACCGCTCAGTGTAAATGTGGATTCTTTTGAGAGCTCtccaaaaatgcaaagtcCATTAAAGCAGGATTTGATGCAATCTCCAACTTCTGTGAAGATGGTGATTAAGAACGGCGTATTAATGCCCAAACAGAAACAACGTAGATACAGAACGGAGCGTCCTTTCACCTGCGAACACTGCTCAGCCCGATTCACACTCAGATCAAACATGGAGAGACATATAAAACAACAACATCCTCAATTTTGGTCTCAGCGGCAGCGAGGTACTTTGGGCCAACCTGGTAGGAAACCTCAAGGTTTGCTCTTGAAGCCGAATTACGCTGAATCTAATCATTACTACGATGAACTGCATAATGATAAGCTGCGTATAGCTTTGTTATCGCAATTGCGTCCCCATCAATATCCAGATGTGAAGAAGGAGGATGAAGAAGATTGTGCTTTAGTTATTGACGAAAACGAACCTAAGAGTGAAGAGGGTTGtaaagaagaagaggaaacTTCTTCggaaaaatgcattaaaaatgaagaagattTGGTGCCAGTGTCCAGGTTATTGGTCAACGCCTCTCAACAACAGTTTAGAGAGTATTTTAATAGAGAAACTGAGGATCATGAATCACTAGGAGTCGGTAGTGAGGAAGATGAAGAAGGCTTAGTCGCTAGTGGGAGTACCAGTGAAGGCAACGTGTCAGGAACAGAAGAAAATCGcTCTGAATCCGAAGCCATAAATCATTCTACTCCAGTGAAGAAGAAATCTGCATATTCTCTAGCACCGAACCGAGTCAGCTGTCCATTTTGCAGCCGCAAATTTCCTTGGACTTCATCATTGCGCCGACATATTCTCACTCATACCGGACAAAAGCCTTTTAAATGTAGTCACTGTCCTCTCCTATTCACCACAAAATCAAATTGCGACCGCCACCTGTTGCGCAAACATGGCAATTCTGCAACCACCATTGTAACTGGCGATGCTTGCAATAGTAACAGCAATTTTCTCATGCGAAATGTCCCTGAGAGACCATTTAAGTGTTCCATCTGTCCAAGTAGTACTTTTTCAACCTATCCAAACTTGAAGAAGCATATGAGCTGTAAGCATACTTCTAGCGTTCAAAGTGACGACATTAAAGCACAAGGCTATGAAGCTGGTAGTTCTGAAGACGAGAAAGTCAATCAGCCCGAGACAAAAAACGAGTGGGAAGCTCAGATTGCTTTCAGTAAATTTCCTGCCGTACCTCCTGAAGTGCCTCCAGCTCAAGTGGCCAATTCCGATTTGCCATTTAAATGTCACTTATGTGAGAGCTCATTTGGGGAACGTAACCAAGCCTTGGACCATATTAGAGACAAACACGCATCTGAATATGACTTATTAATGTCGAAGAATGCTTTGGAAACTCAGGCGACTGAAGAAAGTAGCACACCACACCATGACGATGAAGAGGGTGGCGGCGACATCAGAGGCAAATTTCCAGATTACTCGAATCGCAAAGTGATTTGCGCTTGGTGCATGCGCAGGTTCTGGTCCGCTGAAGATCTGCGTCGTCACATGCGCACTCATACCGGAGAACGACCATTTAGTTGCGACATTTGTCGCCGAAGATTTACATTGAAACACAGCATGTTAAGACACAGAAAGAAACATGCATTAAACAACTTCGAACAGGATACAACACATAGTGATGAAGACGGCTTAGTTCAGGAAGAAGTGTTAAAGAGCGTAACAGGACATGGAAAGATTGAGGATGAACAGTCCGACGTTCAGGATGGGGGAGGTGATTTGATAAGCAATTTGTTAGGTTTAGGGGATCGATCGATTGTCGATAAAGCACTTGACGCTCCGGCCGATGACGTGGCCAAGTTGTTGGGAGTCAAAAATGGGATTAAGGAGTAG
Protein Sequence
MQGVVFTPGNPQQGSPPPNNVMATNMEEPLENNQSNNQIDSGIFSTTANSSIDQTNDSDHRSDCSSPERKYVCPICEKMLTSQHNFTLHIRSHNNENEEINNEKGGFTCRICQKVLSSSSSLDRHVLVHSGERPFQCKYCGDTFTTNGNMHRHMRTHSNKGENYESDGSSDSSSTVRSIEFNNNKVDTKKEVNKRKLEDMDEESSNKRRAECFKCPVCERTDFHSLVVLEAHLEDNHPEHPAKCNVCNQVFLNNKLVIEHKEKVHNNKSHKQQPVMGFDDLTFVDFSSRKFPHIARRECELNIHKSAGGLKFQCSKCSKAFPCSNSLEIHEKNCQEPQNLTVNKPNGISEDEIRRAEFFSRLNLQDNSPEKQHPFNSTLKLKEHLTRAMDSTKDLADIQSILSNIQCQTRQIPSSAKPAAENDKPENEEESQDSFAIEFRKMKLRGEFPCRLCTAVFPNLRALKGHNRAHLSGNTNGTYYCNMCPHSSIDKAALIRHMRTHNGDRPYECSLCNYAFTTKANCERHLRNRHSKTTREEVKKSIIYHPSEDPTNDELNKLTMKSDDNKKDVDADKTILHCSTPKSTSKTKNDVSFPTPTMVPDLQALKPSKIYAAMDFVSQNHKENRFLNGGHPFFSQPFNLMHKTPDVKIQVKPIDSLCENSSFDQSEDEYYDEEEEEPPMDVALDLSKKKSDDEVKSRNDDDNEPQDLTNKAKNATPMLPLPQVSPSVSQFLAQQFLNTSQAKLDPAAIYATHLAYLHRFPAWPMNPLLLQALPALQHPAQDIKERMQRLQLCGGSVITDELKHLTTPPPVSLPPTNQCHGFVQKHETEDKPLSVNVDSFESSPKMQSPLKQDLMQSPTSVKMVIKNGVLMPKQKQRRYRTERPFTCEHCSARFTLRSNMERHIKQQHPQFWSQRQRGTLGQPGRKPQGLLLKPNYAESNHYYDELHNDKLRIALLSQLRPHQYPDVKKEDEEDCALVIDENEPKSEEGCKEEEETSSEKCIKNEEDLVPVSRLLVNASQQQFREYFNRETEDHESLGVGSEEDEEGLVASGSTSEGNVSGTEENRSESEAINHSTPVKKKSAYSLAPNRVSCPFCSRKFPWTSSLRRHILTHTGQKPFKCSHCPLLFTTKSNCDRHLLRKHGNSATTIVTGDACNSNSNFLMRNVPERPFKCSICPSSTFSTYPNLKKHMSCKHTSSVQSDDIKAQGYEAGSSEDEKVNQPETKNEWEAQIAFSKFPAVPPEVPPAQVANSDLPFKCHLCESSFGERNQALDHIRDKHASEYDLLMSKNALETQATEESSTPHHDDEEGGGDIRGKFPDYSNRKVICAWCMRRFWSAEDLRRHMRTHTGERPFSCDICRRRFTLKHSMLRHRKKHALNNFEQDTTHSDEDGLVQEEVLKSVTGHGKIEDEQSDVQDGGGDLISNLLGLGDRSIVDKALDAPADDVAKLLGVKNGIKE

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-