Hdol007258.1
Basic Information
- Insect
- Hyposoter dolosus
- Gene Symbol
- lz
- Assembly
- GCA_963921915.1
- Location
- OY998132.1:9585553-9587382[+]
Transcription Factor Domain
- TF Family
- Runt
- Domain
- Runt domain
- PFAM
- PF00853
- TF Group
- Beta-Scaffold Factors
- Description
- The AML1 gene is rearranged by the t(8;21) translocation in acute myeloid leukemia [1]. The gene is highly similar to the Drosophila melanogaster segmentation gene runt and to the mouse transcription factor PEBP2 alpha subunit gene [1]. The region of shared similarity, known as the Runt domain, is responsible for DNA-binding and protein-protein interaction.In addition to the highly-conserved Runt domain, the AML-1 gene product carries a putative ATP-binding site (GRSGRGKS), and has a C-terminal region rich in proline and serine residues. The protein (known as acute myeloid leukemia 1 protein, oncogene AML-1, core-binding factor (CBF), alpha-B subunit, etc.) binds to the core site, 5'-pygpyggt-3', of a number of enhancers and promoters.
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 1 2.1e-44 7.1e-41 139.0 0.0 3 85 78 160 76 163 0.97
Sequence Information
- Coding Sequence
- ATGCATCTTCCGGTGGACTCAGTGAGCTGCGGCGAGAATTATGGTTGCGTCGGTTCTCATCACGATAGTGCCGGTCTCGTAGTAGGTTCTTCGTTGACGCCTCATCGGGGAGGCGTCGTCGAGCCAAGATATACGACGGAAGAACAGAACGACGAAAGGGGTGGCGGATCCGGTGAGATGAGTGAAGGCGCCGCCGTCGGCGAGCTCTGGTGGACCGAGAGACTCGTCGGCGAAGCACAGGCCGAACATCCTGGTGAACTTGTTCGCACAgGATCGCCATATTTTCTTTGTAGTCAACTTCCGACGCATTGGCGTTCGAACAAAACCCTGCCGGTAGCATTCAAGGTGGTGGCACTTGGTGACGTCAGTGATGGCACCCTCGTCACCGTTAGGGCtggaaacgatgaaaactgtTGCGCTGAGCTGAGGAACGCAACAGCCTTGATGAAGAATCAAGTTGCCAAGTTCAATGACCTCAGTTTGACTTCCCTGTTCTGGTTTTCTGCTCATCCTCCTGGAAACTCCCTGATGCCCTTCTTGTTCCTATAG
- Protein Sequence
- MHLPVDSVSCGENYGCVGSHHDSAGLVVGSSLTPHRGGVVEPRYTTEEQNDERGGGSGEMSEGAAVGELWWTERLVGEAQAEHPGELVRTGSPYFLCSQLPTHWRSNKTLPVAFKVVALGDVSDGTLVTVRAGNDENCCAELRNATALMKNQVAKFNDLSLTSLFWFSAHPPGNSLMPFLFL
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_01101102; iTF_01101840; iTF_01102556; iTF_01100362; iTF_01103321; iTF_01306169;
- 90% Identity
- iTF_01101102;
- 80% Identity
- -