Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 0.00061 0.067 15.0 1.1 1 23 112 134 112 134 0.97

2 6 6.7e-05 0.0073 18.1 0.5 2 23 137 159 137 159 0.94

3 6 2.3e-05 0.0025 19.5 1.1 3 23 167 187 166 187 0.97

4 6 4e-06 0.00043 21.9 0.2 1 23 193 215 193 215 0.97

5 6 0.00039 0.043 15.6 0.0 1 23 221 243 221 243 0.97

6 6 0.0018 0.2 13.6 1.1 1 23 268 291 268 291 0.96

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	0.00061	0.067	15.0	1.1	1	23	112	134	112	134	0.97
2	6	6.7e-05	0.0073	18.1	0.5	2	23	137	159	137	159	0.94
3	6	2.3e-05	0.0025	19.5	1.1	3	23	167	187	166	187	0.97
4	6	4e-06	0.00043	21.9	0.2	1	23	193	215	193	215	0.97
5	6	0.00039	0.043	15.6	0.0	1	23	221	243	221	243	0.97
6	6	0.0018	0.2	13.6	1.1	1	23	268	291	268	291	0.96

Coding Sequence: atgtccGATGAATCGGACCGAGAAGCCGAAAGTCAACGCGACACCGATGACTCGGACGAGCGCCCGCTGGCCAGTCTCTGCAACGACAAGAGTGAAGCGTTTCTGTCCTTTTACGACGCGCTCGTTCGTTTCCGGAACCACGTCGCGAATGAACACAATCGCCGCTCAGAAACGGAATCGAGCGAAGACGACCGAGAGAAGATTATGGAAGAAACTGGAGTGGAAGCTTACGATGATCTATCTCACAGAAACCGGCGACGATCGCGACTCGATCTCGCCACGCGGCAGGAGATAGCGACCGCGCGGACCCGCACTGACGACGGACGGATCGTCTATATCTGCTCTATATGCGGGAAACGTTTAAGCTCGGCACATACCCTAATATTCCACCGTCGAATTCATACAGGCGTGTGCCACATCTGCGGCGCTCAATTCCGCACAGGATCGGGTCTTCAGAGACATTTACAAGAAACTCACGAGCGAAGGCGTCGAGTCGCGTGCCGCACGTGCCAGCGGACGTTCGCGAACGCGCAGaacctcaaacaacacacacgGATACATACAGGGGAGCGGCCGTTTGAATGCGGGGTGTGTGGCAAACGGTTCGCGCAGAGCGGCACCTTGCACGCTCATCGGGCCGTGCATAGGGAAGCTAGGCCGTTTGTTTGTGCGGAGTGCGGGGCGGCTTTTAGACTGAGAGGGGGGCTAGTGAGGCATAGGGCGAGGCATGCGGGACTCCGCGCGCCGTGCCCAAGGAACTCGTTACCACGTGATTCGCGCTCGGCGGGGGAAACGCGGCCGCATGCTTGCCAGCTCTGTCCCGCCGCGTTCCGAGCGCGACGGGCCTTAGCGCACCACCAGCGGAGACTGCACCAGCTGCCCGCGCAACAGCTGCCGATGCAAGCCACGCTAGACAGTCTGCCGCCACCTTATTAA
Protein Sequence: MSDESDREAESQRDTDDSDERPLASLCNDKSEAFLSFYDALVRFRNHVANEHNRRSETESSEDDREKIMEETGVEAYDDLSHRNRRRSRLDLATRQEIATARTRTDDGRIVYICSICGKRLSSAHTLIFHRRIHTGVCHICGAQFRTGSGLQRHLQETHERRRRVACRTCQRTFANAQNLKQHTRIHTGERPFECGVCGKRFAQSGTLHAHRAVHREARPFVCAECGAAFRLRGGLVRHRARHAGLRAPCPRNSLPRDSRSAGETRPHACQLCPAAFRARRALAHHQRRLHQLPAQQLPMQATLDSLPPPY

Sequence clustering based on sequence similarity using MMseqs2