Basic Information

Gene Symbol
topi
Assembly
GCA_964007245.1
Location
OZ023310.1:11882625-11895436[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 17 0.00014 0.013 17.1 2.9 2 21 105 124 104 125 0.93
2 17 0.026 2.4 10.0 0.4 3 23 131 151 130 151 0.94
3 17 0.014 1.3 10.8 0.8 1 23 184 206 184 206 0.94
4 17 0.037 3.4 9.5 0.8 1 23 241 264 241 264 0.92
5 17 0.00013 0.012 17.2 4.0 1 23 270 292 270 292 0.98
6 17 0.029 2.6 9.8 0.5 2 23 300 321 299 321 0.96
7 17 0.69 63 5.5 0.8 1 23 327 350 327 350 0.93
8 17 0.0042 0.38 12.5 0.3 3 23 360 381 359 381 0.93
9 17 0.00021 0.019 16.6 0.4 2 21 493 512 492 513 0.94
10 17 0.0024 0.22 13.2 0.3 2 23 547 569 546 569 0.95
11 17 9e-06 0.00082 20.9 3.5 1 23 574 596 574 596 0.98
12 17 0.36 33 6.4 4.4 2 21 600 619 600 620 0.93
13 17 2e-05 0.0018 19.8 0.6 1 23 646 669 646 669 0.95
14 17 0.0077 0.7 11.6 0.6 1 23 675 697 675 697 0.94
15 17 0.091 8.3 8.3 0.1 1 23 703 725 703 725 0.97
16 17 0.0078 0.71 11.6 0.7 1 23 731 754 731 754 0.94
17 17 1.3e-05 0.0012 20.3 0.3 2 23 761 783 760 783 0.96

Sequence Information

Coding Sequence
ATGCTAGAATATTTCGCgGTGGAAGAAGAGGCAGACCTACCCCCCGGGCTCTGCAGACAGTGCACTGAAGAAGTCCTAACTGCATACTCCTTCAAGCAAATGTGCCATCAATCGGCACAACACTGGGAAGACGCCACCGCATACCTGGCAACAGTGGCAACCTCTACCCTACCTACCGACGAGGATAAAACAATCATTATCTGTCCTCGAGACAAAACAGTCGTCAACATCTCAGAGCCTGCAACAGCAGAAACCGCGATCAAAATCCTAAATGAACCGAAGTGTTATAAAACCAAAAAGAAACGTGCATGTTCCTGTCCACATTGTGGAAAGAGATTCAAGTCTGTAGAAAATCTGAACGAGCATTTCAGATACTCCTCGCAGCGATTCTGTGTCGTTTGCGGTAAGAGTGTCAATAAAAAAAGCTTGGCCAAACATTTGTCTGTGAAGCATAGAATAAAAGTATTGGAGTGCAAGTCTTGCCATGATATATTTAGGAACCACATCGAAGCTCAGACACATAGGGAGAAGAACCACGGATCAGATGTGCATTCGTGCACGTTTTGTGGAGCTGGATTTCCTAATGAGAGGGGTTTGCGAAGCCATACCTACTTGCATAGGCTGTTTAACTGCCACTGTGGTGCTACCTTCGAGAATATTCGATGTTATAAACACCACGGTTCCACTTGCAAGCACGAAAAGCTTTCCGAAGAGTCATTCTTTGAATGCGATCATTGCGGGAACTTATACGACAAAAAACCGTCTCTACGCATCCACATCGTTCAAAAGCACTTAAATATCTTACCATTCAACTGCAAAACATGTGGCAAGCGTACATCTACGCTTGGGCATTTGAAATCTCACGAGAAAACTCATGAAACGGAGCGGCAGCTTTTGGTATGCCGTTATTGCGGGGCCAAATTTCGGACAGATCTGGGGTACAAGTTGCATAAGAGGATACATACAGGCTCGACGCCGTATGAATGCACGTTCTGTGAAGAGAGCTTTCTATCTGCTTCTAGACGGTTAGACCATATTAAAAGACGGCATCAGTCGTCGCAAGAAATGGCTCACGGATGCAAAGAATGCAGTGCTAAGTTTATAAGGCCTTGGGAGTTAAAGAAGCATTATTTTAATATCCACGGTTCGGTTGTTAATATAATAGAAGAGGACTCCTGCCCCATCGGCGCGTGCGTAGGATGCGCAAGCGCCGCCCTCTCCGCTCAAGAATTCCGGCTATTCGTACGAAACTCAGAAAAAATGTGGTACAAAGCAATATTCAATATCGCCAACCTAAAAGTCGATTACGAAGAACGCGCAAAATCAATATGCGCCTTCCTAACACCTACCGACTTATCCGTCCAAACGGCCAAAGACTACACCGGCGGGGAACCAAAAGAAATCGTCAATAGAACTAAAACTATCGTCAAAAAGACCAAACGGAAACCGAGGCGGCACCACCCCGGACCTTTAAGCACTTGCCCTGAATGCAGCAAGACTTTTACATCCCCTTTCTTCTTGCAAGAGCATCTGAAAAACAACGGCCCAAAAACGGCTTGCGCTACTTGCGGGGCTGTAGTAGCTAGAGGACAAGAAATGATCTGCCACATGGCGTTATTTCATAAACAATCCCTAGTAACATGTTCGCAATGTcctaatttattcaaaaatgaaGACGACTTGAGCAAACATATGAAAGACGCTCACAGATCAGGAGTCTTCACTTGTTCTGATTGCGGCAGAACCTTCCCGAGAAAGTCTACGTTCGAGCATCATTCGCAAATGCACGAAGTTCGGACGTGCCGTAGTTGTAACCGGCAGTTTACAAACCGGAGTTGCTACAGAGAGCATAGGAACCAGTGTGAACCTAGCGCTAAGCCAGATAAAAGCACGGTGCCGAGAAATCGTCGCTCAAATATTCGCGATCCTGCCGTTTTTATCTGCGATTACTGCAATAAGAAATATACGTCTCGGCCGCAATTGAAGAATCATATCCTATGGATACATATGGATCATCGACCGCATCAGTGTCAATGGTGTGGAAAGAGGTTCTTTACTGTAGCACGATTAGCTGAGCACACCGTTGTGCATACGCGCGTTCGAAATTTCGAATGTGACATTTGTGGCGCGAAGTTAGTTTCCAAGATGGCGGCGGTTTACCATAGACGGCGTCATACGGGTGAAAAACCATTCAAATGTGAAGACTGCGACGCTAGCTTCATTTCTTCATCGCGTAGACTTGAACATGCTAAAAGAAAGCATAATAAAGGGAAGAGGGTTCAGTGCCCGCTTTGTCCGAATAGTTTTGTACGGAAAAATGAGCTTAAAAGGCATATGGATAAGGCTCATAGTACAGTTGATGAGGAGGATAAAAAAGGCGCACTTATGGATTGGAACGTTGCGCCAGAGCATTCAAAGTTGGAAAATGTTATTATGATATAG
Protein Sequence
MLEYFAVEEEADLPPGLCRQCTEEVLTAYSFKQMCHQSAQHWEDATAYLATVATSTLPTDEDKTIIICPRDKTVVNISEPATAETAIKILNEPKCYKTKKKRACSCPHCGKRFKSVENLNEHFRYSSQRFCVVCGKSVNKKSLAKHLSVKHRIKVLECKSCHDIFRNHIEAQTHREKNHGSDVHSCTFCGAGFPNERGLRSHTYLHRLFNCHCGATFENIRCYKHHGSTCKHEKLSEESFFECDHCGNLYDKKPSLRIHIVQKHLNILPFNCKTCGKRTSTLGHLKSHEKTHETERQLLVCRYCGAKFRTDLGYKLHKRIHTGSTPYECTFCEESFLSASRRLDHIKRRHQSSQEMAHGCKECSAKFIRPWELKKHYFNIHGSVVNIIEEDSCPIGACVGCASAALSAQEFRLFVRNSEKMWYKAIFNIANLKVDYEERAKSICAFLTPTDLSVQTAKDYTGGEPKEIVNRTKTIVKKTKRKPRRHHPGPLSTCPECSKTFTSPFFLQEHLKNNGPKTACATCGAVVARGQEMICHMALFHKQSLVTCSQCPNLFKNEDDLSKHMKDAHRSGVFTCSDCGRTFPRKSTFEHHSQMHEVRTCRSCNRQFTNRSCYREHRNQCEPSAKPDKSTVPRNRRSNIRDPAVFICDYCNKKYTSRPQLKNHILWIHMDHRPHQCQWCGKRFFTVARLAEHTVVHTRVRNFECDICGAKLVSKMAAVYHRRRHTGEKPFKCEDCDASFISSSRRLEHAKRKHNKGKRVQCPLCPNSFVRKNELKRHMDKAHSTVDEEDKKGALMDWNVAPEHSKLENVIMI

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_00827275;
90% Identity
iTF_00827275;
80% Identity
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