Basic Information

Gene Symbol
-
Assembly
GCA_949316085.1
Location
OX438977.1:21248408-21260047[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 7 0.26 28 6.5 0.2 2 21 1719 1738 1718 1739 0.88
2 7 0.00013 0.013 16.9 0.7 2 23 1845 1866 1844 1866 0.95
3 7 0.0015 0.16 13.5 4.0 1 23 1889 1911 1889 1911 0.98
4 7 0.006 0.64 11.6 4.2 1 23 1950 1972 1950 1972 0.98
5 7 0.00029 0.031 15.7 3.4 2 23 1999 2020 1998 2020 0.95
6 7 0.022 2.4 9.8 0.5 1 20 2044 2063 2044 2065 0.94
7 7 0.66 70 5.2 0.8 5 23 2419 2438 2416 2438 0.90

Sequence Information

Coding Sequence
ATGGATAGGTTGAGCCAGTTGAGGGGTGAGGCGGGGAGTTCGCAGGACTCCACACTGGATACCACGTCCTCGCCAAGTGAGGCATTCATAACCGCCAATGAGAGCTCTTCTAAGTTTTATTCTCTGTCAGAAGACGACTCCACATTCGACATTTCGTGCATGAAAGACGACATTTCAATCAAAGATGTATCACTGGCTACAACCACCGCCGAAACTGAAGGTACTCTGACTAATTCTGATGACTTAATATCTAATTTATCACCTATTGGGAAGAAAGCTGATATCTTAGATACCTTCAAAATCCACTCTCACATTGAAGCAGCAAACATTCTATCGGGTGGTGTAGCCATTTTTGATGACAACTCTTATGATGGTAGCGAACTGGTGATAGATGACAATGTAGAAGTAGATGAGAAGTCTAACCCAGAGCTTAAGCAAACTGAGAGCTTGGAGTTTAAACCGGATGAGAACATTGAGACTGGCCTTATTAGTGAAGAAACGGACATCGCAAGTAAGGACACGGAAGTGTTGCTACAGATTGATGGTAAAAATGTTGATGCTATAGACATTGGTAATGGATTATACTTATATAGGAAGGAGGGTCAGGAGGAACTGGCTGCAGTTCAGATCATTGATGATGACCAGCACCAACCCAGTTTTAAGTTCCTCAAAGTACGTGAAAATGCTGAAGGTAACTTAGAAGTTTATGAAGAAATTGAAGTAGAAGTTTCCAAGGAAGTGCCTGCTAAAGAGGGTAAGGCAGTTGATAGAAGTACACCATCTCATGTCCCTATAAGAGATATAAACAAAGTCATTAGTGACTCTAACTGTAACAGAGCAGTAGATAAGCAAATAAAAGTACCAAAAAAAGAACCAACAGTAAGTATCTCAGAAGATAATGACAAAGATTTTGTATCAGAGAGCAAATCAGAGGTCAATTTTAATGGCAAAATGATGAAGTTAAGTGAATCCAGGAAATCGCCGGTTATAGGCAGCTATACACCTATGACTTATCATTCTACCCCTAAGAAAGAAGGTATACCACTTACAAAAACAATGGTAGACCAACAGCTACATCCTAACAGGCACTCAGACCTCTCTAACATTAAAAAGACTATCGAAGTTCATACAGATAATGGTAAAAAGACCTCTGATACACCATCTAAACCCAAAGATATAGATGACACTAAGGTCAATGAAGTTGTACCTATTGAGAAAGAAATGATAACTAATGAAAAAGAAGTTATTAATCtcgaaaatactaaaaataatatcatggTAGATGAAGAGAAAGTTGAGAGAAAATGTGAAGTAAAGGAAAGTTCCGACACGATATCAGAATTAGGTAAACTTAATGAAAAAgattttgatgataaaattaaCAAAGGTATTTCAGAAAAAAGTGAAGATATTCCAGCAAAACAGGATGATTCTATTGATTCTGCAGAAAAAAAGCTAGCTAATAAACAAATAGAAACAACTTCACCACCAAATCCTACCCTTGGAGAAGAAAATGTTAAACCAAATGAAATAGTTAATGAGAAATGTTGCCCATCAAACGATAAAATTGAAGTAATAattgatgaaacaaaaaaacctATAGAAGTAGAGGAAAAGACAGAAGTAACTTTGGTGAAAACAGATCTTTCAGCAAAGGAAAGTAAAGTAGTTTGTGAAGATAATACTCAAAATAAGCAGAAAGAATCTGAAAAAGATAAGGATGTCGATAATACTAAGATTGCTACCAGTGAGCCTATTGTTATTGAGGATGATGATGTGAATATTGTTGAAGTTGTTGTAGAAAACAAAAATCAGAAAGACAATACAGTTAAAGTTACTGATAGTAAGAGCCAGCAACAATTAGATGAAAATAAAGAAGATAATTTGAAAGTACGTGACACCACTGCAATTCCTAGTAAAGATAACAAAGAACCCGAAAAAACAACTGAAAAGGATACAGGTATCATTGTTGTAAAATCTCTCACCGTAGACTCTTTAGCTATGAACTCTGTAGTTCAACCTAAACTCATAAACGAAACAGTTAACAAATCGGAAATGCCTGAACAAGAGCTTAAAAACCCTCCACCTCCAACATCTTCCAGTATTAAAAAGGATACAGTAACTCCACAAGTTCAAGCTaaatcaactgatgatgaagTGGTTAACCCTATAAAAATTGTGAATAAGGATATTTCACatcaagaaaatgaaaatattttagtaaagcCACCTGTAAATGACCCAAAACCAATAGATCTGCTTTCCAATGTTGTAGATGATATGCAAAATAACAAACCAATCGAATCTGCAACAAAGAAAAATGCTGTCCCAAAAGATGGGACAGGAAAACACGTCTTTGCACCTAACATTTCTCCATTATTAGAGCAAAAGCAACAGTCTTTAGTCACATCTAGGGTGGGGTCAATAAAATCAGGATTACCAGAAAAAACGGAAGAAAAGAATCTGTCTCCACCAATTAATGAAATCAGAACAGTCCATAAATTTGTGGAACAGAACATGGAAAAGAAGTTATTTGCTGTAAATTCAAAAACTGTTACCTCAAAACCAATTCCAGGCACTAAATCTACGCCTATCGTGGTACAAATGCAAGTGCACTCAATTAATGCACCTCctcaacattttaataaaaataaagctgTAAGCATAGTCACCAGTGGCATTGAACTTAGAAAAAATACAATCCCAGTACCCACTAAAAATGTAACAGTAGATAAACCTCGACCTGGACTTGCCACTCAAAGAAATGAAGTCAAAGTACCTCCTAAAATGAATGCGCGTGAAAAAGCCAGTTGTGTGATGAATATTGAAATCAGTAAGGTACCCAAGGCAGAATCAGTTAAAACTAGTACTCTAGTAGTCAAACAAACCGACCATAATACGGACAGTAAAGTGAATAATCAAggcttgaaaaataaaattgaaccaAAAGATAAAAAggatatttcaaaaatttctgAATCAAAAcctataaataataatcatgCAGCAGTGCCTTTCGGTAAGTGGACAGAGGCTAACAAGCaagaattcttaaataaatttaaaataaaaacatctgtTACGTCATCCAATAGTAACCAGCTTAAAAATTCCAATGATTTGAATAGAAGAGATGTTCTTAAGAAAATCGACAGTCAAAGACAATCTAGTACTGCTTTATCAAAAACTCAAGAAGCTAACAAGCATATCATGAAATCAGAAATAAGTGCTTTTTCGAATAAACCCAATATAATAACTAAAGAAAGCACACAAGGgagtaaaatattacaaaagactGATATAATAGAAGTCAAACCAAAACCTGCGGTTCCCATAATTGCAACTAAGACAGATGTTGTACCAAAGCAGCAAATTGAATCACAAACAACTGCTGTGAGTGGTTTATCCAAAAAAGAAGTTTGTCAGACAAAAGAGAAAGTACAAAATTTGATTGATATAACGATTGAAGGTATGATACACAGGAATACACATGCTAATAAACCACAAAATGAGActaaacaaaatacaacaaaagaACCTAATCCTCCAAGGACAGCAGCTAGCACAATAGActctcaaaaaaatttaaaaatcattcaaCAACCAACTTCTGACGCTAAACTAGATGAAatagaaatgaaaatgaatgagTTACATGGAATCCCATTCATAGAAAGACCAGCACATGAATTACCACAAGTGCCTAAGGCTGATTCTAAAACTTATTCtattatagaaaaagaaaaggtgGCAGTTCCAGTAAAAACCAAAATACCAAATCTCCTACCATTCCCTAACAAGACTCAACAAAAAATTAGTAAAGAAAGTGTTATAGAAGTAGACTCTGAGGATGAAATTATTGAGCACGAACCTATCACAGGCGATATTGAACTTAATAAGAAAAATCTAATTGTAAAGTCATTAGTTAAGGAAAAGTTACCGATTCAACAAGAAAAAGCAACAATTGAAGCACCTAAAGCCGAACCCATAATTACTGAAAAAGATTTTGATAAATTCGCAAGGAGAAATTCGATTACATGTGAAAATTATCTAACTGTAAATTATGATGGAAAAGAACCACATAATGTGGTTCAAACTGTAGTGGAAAAAGAACcgaatcttaaaaaaaatccaagaaATGATACAGGACGAACGGATCCCATGACAAAACTGTCATATAAACATCAAAATGTACGTCCTTCCACACAAGCAGCGAAACATCATCCAGAAAATACGTTTGCACCAGCAACTGATGATGCTTCAAATAGAAATcaatcaaaattacaaaaagcTTATCATTCCGCTTTGACAGAGAAACGCCAAATGGCTTCAGATTGTCCAATTACTATTATTGAGGATAAACCAGTTAAGGTACTCTTTGTGAATAATGCTGAATATGGTCCAACTCAGTTAAATGTACAGGGTCAAGATCTTTCACccgtaaaaaaaactattcctGACTCAGATGTAACTGATAACACATGCGATTCCCCTAATACAGATTTACTTGATCCTACTGATGATATTAAATCACAAGATGACATGAAAGGCAAGACTAAACATCAAAGAAAACAAGTACTTACTCCCGTTGAAGAACCAGAGTTGGAACTAATTGAACCACAAGACTTAGATATTGATGTTTCacctaaaaagaaaagaagaattGATGAcgataaaattgataaaaacttaaaatatccAATGCGCAAGAAGTATTTACTCAGTTCTAGTACTGTAACAGAAGAGAAAGTAACCAGCCCTATTGAAACAGTGAAACATCCATTAAAAGAGTCTGTTAACCTCAACGATAGTGGCGTGGCACATAGTAATCCTGTTTCAGCATTAGATAGTTTAGTAAAAGCAGCTGAATTAATTGAGACACAAACAGAGAATATGAACAATAGCCTCACATCAAATTCTGACAGTCAGTCAAGTACACCTGTAAAACGAGGACGGGGCCGTCCAAGAAAATATCCTTTAACTCCTGATGGAACAGTTGACAAAAGTAAAGTGACAGTTCCCAGCCCTCAAAAGAAGCCACGACTCATAGATGCTATAAAACCTAAACGAGACGTCACCACTGATGACGACACAGACAGTGAAGGTGAAATTATCAAAGAAAACTGGACTATGGGCAAAATCAACGAAAATATCGTATGCCCAATTTGTAATAAACTGTTCAGAACTGAGAACGTAGTTTTTAAACATGTTAAACATTGCACAGGCCCATCTCCTAACAGATCTGATTCAGATAAGAGAAGTCCAAGAAGAATGAGAATAGACTCTGACAGTAAATCTCAGGACAGTAAGTCCGATGATATGGATATTGATGACGACAAGCCATTAATTACACAAAAATTAAGTCCTAAGAAACGTAAATCCAAAGATTCTAGAACCAAATCACTTGATAAAGATGATGTTATTATCATCGAAGACACactaattaaagaaaaactcgAAAAAACTGAGGAACGAAAAACTCACGTGTCAAGACAATTGACGACTAAGATACCgctcaaaaacaacaatttagttTGTGAATTTTGCGGCAAAACATTTAGGCAACTATCGTATTTGGTAAGCCATAAACTACAACACAAAAAACCACAAAAAGTAGAACCAAGCAAAACGGAAAAGACTGCTCCAATTACTGATAAATCAATATATAGTTGTGAAGTATGTAAAAAAGAGTTCAGAAAATTGCATCACTTGGTTCAGCATCGCATAATACACAACCCCAGCTCAGTAACAGCAAGGTCTTCAAGAAAGAGTTCTTCAGAACAGCCAGAAAACAAAGTTGATAAAGAGCCCAGCACTTCTAAACAAAGTGATGATCCAAGTGCCGGTTTTCGTTGCGAACCGTGCGATAAGTCATTCAGAAAACTACACCATTTAGTGGAACACAGGGAAACCCACGATGGTATAAATCGACAAAAAACAATCACAGTTACTCCAAATAAAGAAGAGAAACCTGTAGAGAAGCCTATTGTGCTTCAATGTGACATTTgcaagaaaacatttaaaaaattatcacaTTTGAATGAACATAAAGAACAACATGTTGAAACGAGTTCAGAAAAATCAGATGACAAAAGTGTTAAGAGTTCTCTTTCTACTAAAGACATTATACACGAATGTTCACTTTGCTACATGGTTTTCCCCAATGAGCATTCACTTAATAAGCATACAGTTATTTGTCAAAGGAAAAAGCGACAGTCTAAACAACCTAAACCAGCAGATGAAACAGAGGGTAACGAGGATGTCATTGAATGTTTATCACCAGAAGAAGAGATTGAGAGTTCGGATTCTAAAAAAACTGAAGTCAGTGAAATTGAAAAAGATGAGGCAAAGAATGAGTTTGTTGAAAAAGTGGAAGTACCAAAAGATAAACCTGTAGAAAAAGAATCATATGCTAGCCAAGAGAAACCGATGGAAAAAGTAAAAGTTGAAGaaccagaaaaaaaattagcaaaatTAGAAGCGAAGACCTCTGAATCACAAACACCACCTCCAAAAACAGATTTGGTATTAGTCGAACCCTCTAACAAAGAGGCAACAGCTGAAATATCtgaaaaaccaaaaaaatcAGAAATCAAAGAGTCTACAAAGATACACGAGACgcctaaaaagaaaatattaattaaagataaaacaGATAAAACGAGTGCTACCAAACGTCCTAAAGCTACGGCCTCCTCCACATCAGCCACTACAGATATAAAACTAGTAGTAGAATCGAGCGATGACGACGAAATCCGGTATATGCTCAACCCGAACTTTAAAGTCGAAGATGTCACTGAAGAAAAAGTCTTCATGAAAGTCAGAGCTAAGAAACGTAGTTCTCTTCAAATAGAACGACCAGACTCCAAAGACTTAATGAAAAGGCGAACTTCATTACAACATCCACCAAAAATACCGCGACTCAAATCAAAATCAATGGAGGCAAATATAACAAtgaaaaaagaagtaaaaactcACAAAGTAGAACCCGTACCTTCAACGGACTCTGACGATAGTGAAACTACAAAATACTCCTTTCCATCGACCATTCCTGAGAAATCGACCAGGCCTGCACAAAATCGGACACCTAAAGATACCGAAAGAAAATCAAGAAAGAAATCCATCGTCGATAAGAGAAAGTCATTAAGTGGGATAGCTAAAAGAAAATCTTTGGGGAAAGCAGCCCCTGCTAGGCACAAACTAACTCCGGTGAAGCAAGTTAAGAAAAGGACGTTGGATGCGGAGCACCGATGCGACTGCGGGCAGTTGTTCAGTAGCGCGGCGCTGCTGTCGCGCCACACCACGCTCGCGCACACGCCGCCGAGGATAAGGCGCCGGCGCTCACCCCCTCCCGACGACAAACCCACACCCATGGAGAAGTCTACGGCCAAACCGGCACCGCGCAAGTCGACCGCACCGGAGAACTCCAAGTCGACTAAGTTACCGCAAGTCGCTGCGTCTAGAAAATCCAACGTTCGAAGCGTCAGCGCCGCGTCGAATGTGAAGTTATCGAAAAGCGAGATCAAACCTGGAAGGAAAACCTTGGATAAGAGTACTAAGTCTCCGAGCGATGCTAAAAAAGCTAAATCGGAGAAGCGCGAGGAGGAATCGAGCGTCAAATCCAGACGGACGACCGCCCATCGAGGCGTTCCCGTTCCGGAAAAGATGAAAAAACTTCAAGGGAAGACCAAGTAA
Protein Sequence
MDRLSQLRGEAGSSQDSTLDTTSSPSEAFITANESSSKFYSLSEDDSTFDISCMKDDISIKDVSLATTTAETEGTLTNSDDLISNLSPIGKKADILDTFKIHSHIEAANILSGGVAIFDDNSYDGSELVIDDNVEVDEKSNPELKQTESLEFKPDENIETGLISEETDIASKDTEVLLQIDGKNVDAIDIGNGLYLYRKEGQEELAAVQIIDDDQHQPSFKFLKVRENAEGNLEVYEEIEVEVSKEVPAKEGKAVDRSTPSHVPIRDINKVISDSNCNRAVDKQIKVPKKEPTVSISEDNDKDFVSESKSEVNFNGKMMKLSESRKSPVIGSYTPMTYHSTPKKEGIPLTKTMVDQQLHPNRHSDLSNIKKTIEVHTDNGKKTSDTPSKPKDIDDTKVNEVVPIEKEMITNEKEVINLENTKNNIMVDEEKVERKCEVKESSDTISELGKLNEKDFDDKINKGISEKSEDIPAKQDDSIDSAEKKLANKQIETTSPPNPTLGEENVKPNEIVNEKCCPSNDKIEVIIDETKKPIEVEEKTEVTLVKTDLSAKESKVVCEDNTQNKQKESEKDKDVDNTKIATSEPIVIEDDDVNIVEVVVENKNQKDNTVKVTDSKSQQQLDENKEDNLKVRDTTAIPSKDNKEPEKTTEKDTGIIVVKSLTVDSLAMNSVVQPKLINETVNKSEMPEQELKNPPPPTSSSIKKDTVTPQVQAKSTDDEVVNPIKIVNKDISHQENENILVKPPVNDPKPIDLLSNVVDDMQNNKPIESATKKNAVPKDGTGKHVFAPNISPLLEQKQQSLVTSRVGSIKSGLPEKTEEKNLSPPINEIRTVHKFVEQNMEKKLFAVNSKTVTSKPIPGTKSTPIVVQMQVHSINAPPQHFNKNKAVSIVTSGIELRKNTIPVPTKNVTVDKPRPGLATQRNEVKVPPKMNAREKASCVMNIEISKVPKAESVKTSTLVVKQTDHNTDSKVNNQGLKNKIEPKDKKDISKISESKPINNNHAAVPFGKWTEANKQEFLNKFKIKTSVTSSNSNQLKNSNDLNRRDVLKKIDSQRQSSTALSKTQEANKHIMKSEISAFSNKPNIITKESTQGSKILQKTDIIEVKPKPAVPIIATKTDVVPKQQIESQTTAVSGLSKKEVCQTKEKVQNLIDITIEGMIHRNTHANKPQNETKQNTTKEPNPPRTAASTIDSQKNLKIIQQPTSDAKLDEIEMKMNELHGIPFIERPAHELPQVPKADSKTYSIIEKEKVAVPVKTKIPNLLPFPNKTQQKISKESVIEVDSEDEIIEHEPITGDIELNKKNLIVKSLVKEKLPIQQEKATIEAPKAEPIITEKDFDKFARRNSITCENYLTVNYDGKEPHNVVQTVVEKEPNLKKNPRNDTGRTDPMTKLSYKHQNVRPSTQAAKHHPENTFAPATDDASNRNQSKLQKAYHSALTEKRQMASDCPITIIEDKPVKVLFVNNAEYGPTQLNVQGQDLSPVKKTIPDSDVTDNTCDSPNTDLLDPTDDIKSQDDMKGKTKHQRKQVLTPVEEPELELIEPQDLDIDVSPKKKRRIDDDKIDKNLKYPMRKKYLLSSSTVTEEKVTSPIETVKHPLKESVNLNDSGVAHSNPVSALDSLVKAAELIETQTENMNNSLTSNSDSQSSTPVKRGRGRPRKYPLTPDGTVDKSKVTVPSPQKKPRLIDAIKPKRDVTTDDDTDSEGEIIKENWTMGKINENIVCPICNKLFRTENVVFKHVKHCTGPSPNRSDSDKRSPRRMRIDSDSKSQDSKSDDMDIDDDKPLITQKLSPKKRKSKDSRTKSLDKDDVIIIEDTLIKEKLEKTEERKTHVSRQLTTKIPLKNNNLVCEFCGKTFRQLSYLVSHKLQHKKPQKVEPSKTEKTAPITDKSIYSCEVCKKEFRKLHHLVQHRIIHNPSSVTARSSRKSSSEQPENKVDKEPSTSKQSDDPSAGFRCEPCDKSFRKLHHLVEHRETHDGINRQKTITVTPNKEEKPVEKPIVLQCDICKKTFKKLSHLNEHKEQHVETSSEKSDDKSVKSSLSTKDIIHECSLCYMVFPNEHSLNKHTVICQRKKRQSKQPKPADETEGNEDVIECLSPEEEIESSDSKKTEVSEIEKDEAKNEFVEKVEVPKDKPVEKESYASQEKPMEKVKVEEPEKKLAKLEAKTSESQTPPPKTDLVLVEPSNKEATAEISEKPKKSEIKESTKIHETPKKKILIKDKTDKTSATKRPKATASSTSATTDIKLVVESSDDDEIRYMLNPNFKVEDVTEEKVFMKVRAKKRSSLQIERPDSKDLMKRRTSLQHPPKIPRLKSKSMEANITMKKEVKTHKVEPVPSTDSDDSETTKYSFPSTIPEKSTRPAQNRTPKDTERKSRKKSIVDKRKSLSGIAKRKSLGKAAPARHKLTPVKQVKKRTLDAEHRCDCGQLFSSAALLSRHTTLAHTPPRIRRRRSPPPDDKPTPMEKSTAKPAPRKSTAPENSKSTKLPQVAASRKSNVRSVSAASNVKLSKSEIKPGRKTLDKSTKSPSDAKKAKSEKREEESSVKSRRTTAHRGVPVPEKMKKLQGKTK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
iTF_01198257;
90% Identity
-
80% Identity
-