Basic Information

Gene Symbol
-
Assembly
GCA_030762935.1
Location
CM060895.1:81124310-81137033[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 4 9.9e-06 0.0042 20.1 3.8 1 23 129 151 129 151 0.98
2 4 3e-06 0.0013 21.7 0.1 5 23 153 171 152 171 0.96
3 4 5e-07 0.00021 24.2 0.7 1 23 177 199 177 199 0.99
4 4 0.73 3.1e+02 4.8 0.6 1 8 205 212 205 213 0.90

Sequence Information

Coding Sequence
ATGTCTGTTGGAGATAATCTACCAGCTCAGATATGTCTCCAGTGTGCTCATCAAATTAAAGAAGAAGACGAAGATGTTGCAGAAACTTCTGAGATAACTAAAGAGTTGGTTGCAGTGAAGACAGAAGAAACTACAGTTGCAGATACAGAAAAAGATACAAATGCCATGACTAGTGGatttttagaaGATAATGGGAACTCTAATTCCTCAGATTCGTGGCCAGAAACAAAAGATGATATTAAAAAGGAAGAGTCCACTGCatcaactactaccaccaccaccactactacaactaccacctcAGGATCAACTTCCACCTCAACACCAGCAAAGCCACGCAGAGGAAGGCCGCCTTTGTCTAAGAACAAAAAGCTTGAGAGACCTTTTCACTGCACTATCTGCAACAAATACTTTGCCCAGAAGGAGGGCCTAGCAAGACATCACAGAATTCACACTGTATGTGGGAAAAGCTTTGGCCAAAACTCGGCACTGCTGAGTCACATGCGCACCCATACAGGTGAGAAACCCTTTCAGTGTAATCTCTGTGGAGCAAAGTTTGCACAGAATTATGGTCTCACCTATCACATGCGCAGTCATATGGGCGAAAAGCCATATCAGTGTACCCACTGCGGTATGATTCCTCCTAACTCCAATATGACGTTATCTCCAGGAGCAAATAGTCTTATACACCACCCTAGCCCACCCAATTTACATAGTCCAAACCACATGATGCCAACAAATATGAATAGCATGCCTCATGGTATGAACACCATCCCCACTCCTATTAACAGTGCTAATAGTGTTGATCACATGGGTAAATAG
Protein Sequence
MSVGDNLPAQICLQCAHQIKEEDEDVAETSEITKELVAVKTEETTVADTEKDTNAMTSGFLEDNGNSNSSDSWPETKDDIKKEESTASTTTTTTTTTTTTSGSTSTSTPAKPRRGRPPLSKNKKLERPFHCTICNKYFAQKEGLARHHRIHTVCGKSFGQNSALLSHMRTHTGEKPFQCNLCGAKFAQNYGLTYHMRSHMGEKPYQCTHCGMIPPNSNMTLSPGANSLIHHPSPPNLHSPNHMMPTNMNSMPHGMNTIPTPINSANSVDHMGK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-