Basic Information

Insect: Hyles lineata
Gene Symbol: Hnf4
Assembly: GCA_030180105.1
Location: JARJEE010000018.1:6630616-6645869[+]

Transcription Factor Domain

TF Family: RXR-like
Domain: zf-C4|RXR-like
PFAM: AnimalTFDB
TF Group: Zinc-Coordinating Group
Description: DNA-binding domain of retinoid X receptor (RXR) is composed of two C4-type zinc fingers. Each zinc finger contains a group of four Cys residues which co-ordinates a single zinc atom. RXR functions as a DNA binding partner by forming heterodimers with other nuclear receptors including CAR, FXR, LXR, PPAR, PXR, RAR, TR, and VDR. All RXR heterodimers preferentially bind response elements composed of direct repeats of two AGGTCA sites with a 1-5 bp spacer. RXRs can play different roles in these heterodimers. RXR acts either as a structural component of the heterodimer complex, required for DNA binding but not acting as a receptor, or as both a structural and a functional component of the heterodimer, allowing 9-cis RA to signal through the corresponding heterodimer. In addition, RXR can also form homodimers, functioning as a receptor for 9-cis RA, independently of other nuclear receptors. Like other members of the nuclear receptor (NR) superfamily of ligand-activated transcription factors, RXR has a central well conserved DNA binding domain (DBD), a variable N-terminal domain, a flexible hinge and a C-terminal ligand binding domain (LBD). [cite:PUB00121610], [cite:PUB00121611], [cite:PUB00121612], [cite:PUB00025660], [cite:PUB00121613], [cite:PUB00092048], [cite:PUB00092725], [cite:PUB00092726], [cite:PUB00016724], [cite:PUB00059514PMID:18971932
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 13 6.2e-63 1.9e-59 201.5 0.0 1 197 212 405 212 409 0.94

2 13 3e-09 9e-06 26.2 0.0 159 197 412 450 405 454 0.90

3 13 3.1e-09 9.2e-06 26.2 0.0 159 197 457 495 450 498 0.90

4 13 3.3e-09 9.9e-06 26.1 0.0 160 197 503 540 496 544 0.91

5 13 3e-09 9e-06 26.2 0.0 159 197 547 585 540 589 0.90

6 13 2.9e-09 8.7e-06 26.2 0.0 159 197 592 630 584 634 0.90

7 13 3e-09 9e-06 26.2 0.0 159 197 637 675 630 679 0.90

8 13 3e-09 9e-06 26.2 0.0 159 197 682 720 675 724 0.90

9 13 2.9e-09 8.8e-06 26.2 0.0 159 197 727 765 720 770 0.90

10 13 3e-09 9e-06 26.2 0.0 159 197 772 810 765 814 0.90

11 13 3e-09 9e-06 26.2 0.0 159 197 817 855 810 859 0.90

12 13 3.1e-09 9.2e-06 26.2 0.0 159 197 862 900 855 903 0.90

13 13 2.7e-09 8.1e-06 26.4 0.0 159 198 907 946 900 950 0.89

#	of	c-Evalue	i-Evalue	score	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	13	6.2e-63	1.9e-59	201.5	1	197	212	405	212	409	0.94
2	13	3e-09	9e-06	26.2	159	197	412	450	405	454	0.90
3	13	3.1e-09	9.2e-06	26.2	159	197	457	495	450	498	0.90
4	13	3.3e-09	9.9e-06	26.1	160	197	503	540	496	544	0.91
5	13	3e-09	9e-06	26.2	159	197	547	585	540	589	0.90
6	13	2.9e-09	8.7e-06	26.2	159	197	592	630	584	634	0.90
7	13	3e-09	9e-06	26.2	159	197	637	675	630	679	0.90
8	13	3e-09	9e-06	26.2	159	197	682	720	675	724	0.90
9	13	2.9e-09	8.8e-06	26.2	159	197	727	765	720	770	0.90
10	13	3e-09	9e-06	26.2	159	197	772	810	765	814	0.90
11	13	3e-09	9e-06	26.2	159	197	817	855	810	859	0.90
12	13	3.1e-09	9.2e-06	26.2	159	197	862	900	855	903	0.90
13	13	2.7e-09	8.1e-06	26.4	159	198	907	946	900	950	0.89

Sequence Information

Coding Sequence: ATGCCGGTACTGGGCTACGGAGAGATGGCCTCGCAAGACATGTGTCCCATGGGATACAGCTCGGACTACATGCTGCCGACCTCCTGGGACAAGCACGTTGAAGGGTACTCGGCATACGCGCACCGCGTCCCGGTCTCCAGCGCCGTCGCCACCACATACAACACAGAAGACAGTGACATGCAACTGGAGACGAGCAGCAGCGAGGCGAGCGCCACCAGCTCGACGCCGCTGTCGCAGCACTGCGCCATCTGCGGCGACCGCGCCACCGGCAAGCACTACGGAGCCTCCTCCTGCGACGGCTGCAAGGGATTCTTCAGGCGAAGTGTCAGGAAGAACCATTTGTATACGTGCAGATTTAGCAGAAACTGCGTGGTGGACAAAGACAAAAGGAATCAGTGCCGATACTGTAGGTTAAGGAAATGTTTCAAAGCGGGAATGAAAAAAGAAGCGGTGCAGAACGAACGCGATCGTATCAACTGCCGGCGGCCGTCGTACGAGGAGCCCACGCAGGCCAACGGCCTGTCTGTCGTGTCGCTGTTGAACGCTGAGCTGCTCAGCAGAAAGGTCATTGATGAAACGATAAACGTGAGCGACGCGGAGATAAACAACAGAAAGCTGGCGAAGATCAACGACGTGTGCGACTCCATAAAGCAGCAGCTGCTCATACTGGTGGAGTGGGCCAAGTACATCCCCGCCTTCACAGAGCTGCATCTAGATGATCAGGTGGCGCTGCTGCGCGCGCACGCGGGCGAGCACCTGCTGCTGGGCTGCGCGCGCCGCTCGCTGCACCTGCGCGACATCCTGCTGCTCGGCAACAACTGCATCATCACCAAGCACAACATCGACGGTCGCATGGACATCGACATCAGCATGATCGGCATGCGCGTGATGGACGAGATCGTGAAACCGCTGCGAGAGATCGACATCGACGACACTGAGTTTGCGTGTCTCAAAGCGATCGTGTTCTTTGACCCTAACGCGAAAGGCCTCTCGCAGCCGCAGAAGATCAAGCAGCTGCGCTACCAGATCCAGATCAACCTGGAGGACTACATCAGCGACCGGCAGTATGACGGCCGCGGCCGCTTCGGAGAGCTGCTGCTGTGTCTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGTGAGATATTACTGTATGTAGTGGGAGTGCCGCCGCTGCAGAGCATCACGTGGCAGATGATCGAGCAGATACAGTTCGCCAAGCTGTTCGGAGTCGCGCACGTGGACAGCCTGCTGCAGGAGATGCTGCTTGGAGGCGCATCAACAGAAGCGGGTATAGAGGAGGGCAGCGCCGcgtgcgcggcgggcgcgggcgcggccgaGTGTCGCGCGGGGTCGCCGCCGCTCGTGCCCACGCTGCCGCTCGCCTTCACGCCCATGCCCTTCAAGCAGGAGCCCAACATGAGCCCAGGGCCCGACTCACAAATGGCGAAGACTGCtgacattacattattatag
Protein Sequence: MPVLGYGEMASQDMCPMGYSSDYMLPTSWDKHVEGYSAYAHRVPVSSAVATTYNTEDSDMQLETSSSEASATSSTPLSQHCAICGDRATGKHYGASSCDGCKGFFRRSVRKNHLYTCRFSRNCVVDKDKRNQCRYCRLRKCFKAGMKKEAVQNERDRINCRRPSYEEPTQANGLSVVSLLNAELLSRKVIDETINVSDAEINNRKLAKINDVCDSIKQQLLILVEWAKYIPAFTELHLDDQVALLRAHAGEHLLLGCARRSLHLRDILLLGNNCIITKHNIDGRMDIDISMIGMRVMDEIVKPLREIDIDDTEFACLKAIVFFDPNAKGLSQPQKIKQLRYQIQINLEDYISDRQYDGRGRFGELLLCLPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGEILLYVVGVPPLQSITWQMIEQIQFAKLFGVAHVDSLLQEMLLGGASTEAGIEEGSAACAAGAGAAECRAGSPPLVPTLPLAFTPMPFKQEPNMSPGPDSQMAKTADITLL

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: iTF_00819277;
90% Identity: iTF_00819277;
80% Identity: iTF_00819277;