Basic Information

Gene Symbol
-
Assembly
GCA_963513945.1
Location
OY740718.1:29312187-29322202[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 10 6.6e-05 0.0057 17.9 0.9 1 23 233 255 233 255 0.97
2 10 0.00016 0.014 16.7 7.3 1 23 264 286 264 286 0.98
3 10 5.8e-05 0.005 18.1 1.1 1 23 345 367 345 367 0.98
4 10 6.5e-07 5.6e-05 24.2 2.6 1 23 381 403 381 403 0.99
5 10 1.1e-05 0.00096 20.3 1.3 1 23 409 431 409 431 0.95
6 10 0.00064 0.055 14.8 0.3 1 23 437 459 437 459 0.96
7 10 0.00056 0.048 15.0 1.0 1 23 465 487 465 487 0.96
8 10 0.0039 0.33 12.3 5.1 1 23 493 515 493 515 0.98
9 10 3.4e-06 0.0003 21.9 0.6 1 23 521 543 521 543 0.98
10 10 5.5e-05 0.0047 18.1 0.7 1 23 549 571 549 571 0.99

Sequence Information

Coding Sequence
ATGGGAGAAAACGAATCATATTTTAACTGCCAACCAAGACTGAGAAGGCATACGCCAGATCTAATTTCCATATTCAATGAACCACAATCAAGTACAACTACCCTGGGAGTTACAATAATGGACCTACTTCAATTAACCGTTCCGCGGCTAACAATCGCAGCCGACGACTTCTTaccaaaaaaagtatgttcttaCTGCGTTGACAATTTGGTAACAATTCAGGAATTTCAACAAATGTGCATCCGAGTGGAGCAGCGATTTCAGGAGTTAATAAATGGGCACCAAGAGACGACGGAGGTTAATGTAACCGATCCCTTGAATAGCAATACAATGGATCAAGCTTTCAATGATTTAAGTAATGTGTTGAAGATTGAAATGGACGATACCGTAGCAGATGACATTGCTTATGCCGCCCAAAAAGACGAGAGAATAAAGGTTGTTGAAGTGTGCAAAACTGGCAATGATTCTGTTACTGGGGAACAAGACGAGACTGACAGCTGTAATGATGGGAATGACCTTGATGAGTCAGATTCTGAGTGGGAACCCGATGCTGACAATAATACTAGAAAACGTAAATGTGAGAGCCCTGACAAAACTGCGAAACCACATTTGGAAGTGTATAACAAAAGTGACGATTCACGGGAATTCCCTATACCTGAAATATGTAAACCAGAGGACTTTGACGATAAGAAGCCATTTGCATGTGATGAATGCGGCAATAGactgaaaacaagtaaaagtctTAAAAGACACCAACTAATGCATTTACGACAATCTAACGAAAAGGAGCATAAGTGTAAACATTGTAATAGAGTTTTCCAAAAGCTAAGCTCTTtaagaaatcatttaaaaagtcaTAGAGATAACTATTGTGATGCTGATATCAATGACCACAGTGAGAGCAGTAATGAAGATGATGATTTAGAGGATGCAGATGGAGAACATCACAATAAGACCGAAACAAATGAGGGCGAAATCACACAGGCAAGTAATgaagttgaaaaacaaaaagatgacTTCCAACAAAAGCCATATGTCTGTGGGCAATGTGGTAGTCGACTGAAAACTCGCAAAAGTCTAAAGCGCCATCTTCGAATACACTTACGACAACCTGGCGAAAGAggacaaataaaagcaaaatatgAATGTGAACATTGCAAGAAagTGTTTCAACAATCCAGTTCGCTTAAGGATCACTTAAGAGTACATACCGGTGAACAGCCGTATCTTTGTTCCGAATGTGGCAAAGCATTCAAAAGCTTAAGTAATATGAAACAACATTTTCTACGTCACGGTACTGATCGTCCGTACGAATGTCCCGACTGTCCTAAAAAATTTCCCTGTCTCAGTGATTTGGCGTCCCATAAGGCGGTGCATTCAAAGCAGAAATCGCATGTGTGTGATGTGTGTGGAGCTGGTTTCTTTAAACCCTACTTgctgaaaaaacataaaatgtaccataatggagaaaaaaatcacaaatgtGATTACTGCGAAATGAGATTTGTCCTAGCTGACCAATGCAGACGACACATGCGAACTCACACTGGGGAAAAGCCCTACAAATGTAAATACTGCGTCAGAGCATTTGCGCAAAGTAATGATTTGATCAAGCACCTACGCGGTCACTTGGGAGACAATGTATACAAATGTGATATGTGTCCTCAGGGATTCCGTTTGCAAGGAGATTTAAGAACGCATTTTAATACACACAAAAACGATGATGATGAAACTAGACTACGAAATTTACAAGCCCTTAAGGATGATGAATTACGAATACAAATGAAATTCGGTCTTGTGCAAGCCAGCAAAGAGCACTGA
Protein Sequence
MGENESYFNCQPRLRRHTPDLISIFNEPQSSTTTLGVTIMDLLQLTVPRLTIAADDFLPKKVCSYCVDNLVTIQEFQQMCIRVEQRFQELINGHQETTEVNVTDPLNSNTMDQAFNDLSNVLKIEMDDTVADDIAYAAQKDERIKVVEVCKTGNDSVTGEQDETDSCNDGNDLDESDSEWEPDADNNTRKRKCESPDKTAKPHLEVYNKSDDSREFPIPEICKPEDFDDKKPFACDECGNRLKTSKSLKRHQLMHLRQSNEKEHKCKHCNRVFQKLSSLRNHLKSHRDNYCDADINDHSESSNEDDDLEDADGEHHNKTETNEGEITQASNEVEKQKDDFQQKPYVCGQCGSRLKTRKSLKRHLRIHLRQPGERGQIKAKYECEHCKKVFQQSSSLKDHLRVHTGEQPYLCSECGKAFKSLSNMKQHFLRHGTDRPYECPDCPKKFPCLSDLASHKAVHSKQKSHVCDVCGAGFFKPYLLKKHKMYHNGEKNHKCDYCEMRFVLADQCRRHMRTHTGEKPYKCKYCVRAFAQSNDLIKHLRGHLGDNVYKCDMCPQGFRLQGDLRTHFNTHKNDDDETRLRNLQALKDDELRIQMKFGLVQASKEH

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-