Basic Information

Gene Symbol
ZEB1
Assembly
GCA_963513945.1
Location
OY740719.1:160658716-160667948[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 22 6.3e-06 0.00054 21.1 1.7 2 23 21 42 20 42 0.97
2 22 8e-05 0.0069 17.6 1.2 1 23 48 72 48 72 0.96
3 22 1.2 1e+02 4.5 0.8 1 23 79 104 79 104 0.91
4 22 3.9e-05 0.0033 18.6 0.6 1 23 113 135 113 135 0.96
5 22 0.0068 0.58 11.6 0.6 1 23 143 167 143 167 0.97
6 22 0.0016 0.14 13.5 0.6 1 23 173 195 173 195 0.98
7 22 0.0001 0.0089 17.3 0.2 1 23 201 224 201 224 0.97
8 22 0.022 1.9 9.9 2.2 1 23 237 259 237 259 0.98
9 22 1.3e-05 0.0011 20.1 1.5 1 23 266 288 266 288 0.98
10 22 2.3e-05 0.002 19.3 2.1 1 23 293 315 293 315 0.99
11 22 3.2e-05 0.0027 18.9 0.3 1 23 322 344 322 344 0.95
12 22 0.0012 0.11 13.9 0.7 1 23 351 373 351 373 0.97
13 22 1.7 1.5e+02 4.0 0.4 9 23 389 403 387 403 0.88
14 22 0.0036 0.31 12.5 1.5 1 23 409 433 409 433 0.94
15 22 0.0074 0.64 11.4 1.8 1 23 440 464 440 465 0.96
16 22 0.23 20 6.7 3.8 1 17 484 500 484 506 0.86
17 22 0.31 26 6.4 0.3 1 23 514 538 514 538 0.96
18 22 0.0094 0.8 11.1 1.0 1 23 544 566 544 566 0.96
19 22 0.0068 0.58 11.6 1.1 1 23 572 595 572 595 0.93
20 22 0.01 0.89 11.0 0.6 1 21 612 632 612 634 0.81
21 22 5.5e-06 0.00048 21.3 0.2 1 23 640 662 640 662 0.98
22 22 0.0057 0.49 11.8 0.4 1 23 669 691 669 691 0.97

Sequence Information

Coding Sequence
ATGCCAGATTATACCGAGGCACCAGACGTTATAGAAAAAACCCGTAGCAAATATCCACTCAAATGTGACATTTGCCCGAAAGCGTTTCGCTATTCACATCGTCTAGAAGCCCACCAACGGAGGCATAGGGGCTTGCCAGAATATCCCTGTTCGTTTGAAAATTGTTCACGAGCTTTCAGTCGCCTGTCTGACTTGAGACATCACATCAATGACCACAATGGCATCGTTAATGCCTATAAATGTGACATCGAAAATTGCGACGTGGTGTTTCCAAGCATGCATTTACGCTACCAACATAAGATCAAAGACCATAAAGTCGGGAAAGAGTTGAAGACATATTCTTGTGAAACATGCGGTAAAACATTAACAACACCGCGATCACTTCAAGCCCATCGTTTTCTTCATCGAGATAAATCAGAATGGCCGTTTAGTTGTGATGTAGAAGGTTGCGACATAAAATTCAGATTTTTGGCCCAAAAGAAAATTCATATGAAGCGTCATGCCGGCATAAAGAACTATGTTTGTCCCCATTGTGGCATGCGAAAAACCACTAGCACGGAACTTAGTATTCACATCAACTTACACACATTCGAAAAAAAGTATCCCTGTCGTATTTGCTCGAAAGTGTTCAAAAGTGTGGGATCCATGAGCACGCACATTCGGGTCGTCCACGAAGGAAAACTAAGAACGGCTGCCAGAATTGGGACTTTTCAGTGTAGCTACTGTGATCGCAAATTAAGCACAGCTATGACCAAGAAATACCACGAAATGACTCATACAGGAGAAAGTAAACCGTACGAGTGTGATGAATGTGGCAAAACATTCGTGTCGCCATCAATCCTAAAGCATCATAAGAATAAGCACGGTGAGAAAAAATACGAATGTAAGGAATGCGGCAAGCGGTACAAATGGCCAATGCACTTGAAGACACATATGAAGGTTCATTTGGAGGGAGCCAATCCGTTTCCTTGTGAGATCTGTGGTAAAAGATTCAAATGGCAAGATAACTTAAAGTCTCATTTAGTGTTACACAATGAAGGAGTAACTCCCTATACATGTGAGATATGCGGCAAGGGATTCAGATGGCCAGGATCTTTTTATACTCATAAGAAAAATCACTTGAAACAGAAAGTAGATGTTAAACAAGAAGACGATGCAAGAGAAGTTTTTTATGCACAACATTGCTTGGAGGCGCACCAGCGAAGGCATCAAGGTTTATCCGGACATCCCTGTACATTTGAGAATTGCAATCGTGCTTACAATCGCATCACTGACTTGAAAAGGCATCTCAATGAACACAGTGGCATTCCAAATATCTTCAAGTGCGACATCGACAATTGCAACAAGGAATATTCGGCCTATGCTGCGCTGAACTATCACAGAAGGAAACACCACAAACATGGAAAGGAACTGCGAAATCCCAAGTATCAAATACAAATGTCCAAGGACTTCATATGCGAAACATGCGGCAAAGCCTTTTCTAGCGCATTTCGTCTGAAATGTCACTGTTTACTGCACGTCGATAAGTCCGAATGGCCGTTTGTCTGCGATGCCGAGGGCTGTACGATGAGATTTCGAGCTATGGAAAGGTTGAAAATACACAAAATGCGCCATACCGGTATCAAGAACTTTGTTTGTCCCCATTGTGGCGTGCGTAAAACGACCAAGAATGAACTCAATATTCATGTAAATTTCCATACATTCGAACGGAAATATCCTTGTCATCTGTGTTCCAAAGTGTTCAAAAGTGTGGGGCTGGTCAGTACACATGTGCATATCGTTCACGAAGGCAAACGCCCTAAACCAAAGCCAAAAAAGCCGGCAAATACCATTTATGCGTGTAGTTATTGTGATCGTACATTCCGCAATCCCCTGGGCAAGAAATATCATGAAATAGGCCATACGGGCGAAAAGCCCTATGAATGTGAGGaatgtggcaaaaaatttgccGTACCGGGAAGTTTGAAGTCCCATAAGAAGTTGCACGTAGAAGGCGCCACACCGTACGCGTGTGAGGAGTGTGGTCAAAAATTCCGATGGCCAGGATCCTATTACGCTCATAAGAAAAAGCATGTTATGCAGAAGGATGAAAATGTGCAAGGAGACGGAGAGATAACGAAAGATAGCGTTGAGCCACAGAACCCGAAGAAAGATTTCaactaa
Protein Sequence
MPDYTEAPDVIEKTRSKYPLKCDICPKAFRYSHRLEAHQRRHRGLPEYPCSFENCSRAFSRLSDLRHHINDHNGIVNAYKCDIENCDVVFPSMHLRYQHKIKDHKVGKELKTYSCETCGKTLTTPRSLQAHRFLHRDKSEWPFSCDVEGCDIKFRFLAQKKIHMKRHAGIKNYVCPHCGMRKTTSTELSIHINLHTFEKKYPCRICSKVFKSVGSMSTHIRVVHEGKLRTAARIGTFQCSYCDRKLSTAMTKKYHEMTHTGESKPYECDECGKTFVSPSILKHHKNKHGEKKYECKECGKRYKWPMHLKTHMKVHLEGANPFPCEICGKRFKWQDNLKSHLVLHNEGVTPYTCEICGKGFRWPGSFYTHKKNHLKQKVDVKQEDDAREVFYAQHCLEAHQRRHQGLSGHPCTFENCNRAYNRITDLKRHLNEHSGIPNIFKCDIDNCNKEYSAYAALNYHRRKHHKHGKELRNPKYQIQMSKDFICETCGKAFSSAFRLKCHCLLHVDKSEWPFVCDAEGCTMRFRAMERLKIHKMRHTGIKNFVCPHCGVRKTTKNELNIHVNFHTFERKYPCHLCSKVFKSVGLVSTHVHIVHEGKRPKPKPKKPANTIYACSYCDRTFRNPLGKKYHEIGHTGEKPYECEECGKKFAVPGSLKSHKKLHVEGATPYACEECGQKFRWPGSYYAHKKKHVMQKDENVQGDGEITKDSVEPQNPKKDFN

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
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90% Identity
-
80% Identity
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