Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 6 2.4e-05 0.0018 18.6 1.6 2 23 173 194 172 194 0.97

2 6 9.7e-07 7.1e-05 23.0 1.6 2 23 202 223 201 223 0.97

3 6 0.00014 0.011 16.2 1.0 1 23 229 251 229 251 0.97

4 6 0.00049 0.036 14.5 0.1 1 17 257 273 257 274 0.95

5 6 0.0018 0.13 12.7 0.9 3 23 287 307 285 307 0.97

6 6 4.4e-05 0.0032 17.8 7.2 1 23 313 335 313 335 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	6	2.4e-05	0.0018	18.6	1.6	2	23	173	194	172	194	0.97
2	6	9.7e-07	7.1e-05	23.0	1.6	2	23	202	223	201	223	0.97
3	6	0.00014	0.011	16.2	1.0	1	23	229	251	229	251	0.97
4	6	0.00049	0.036	14.5	0.1	1	17	257	273	257	274	0.95
5	6	0.0018	0.13	12.7	0.9	3	23	287	307	285	307	0.97
6	6	4.4e-05	0.0032	17.8	7.2	1	23	313	335	313	335	0.98

Coding Sequence: ATGCAGCAAGGACAGCAGTTGAGTTCGGTTTGTCGCGCTTGTCTCACGAATGATGGTAGATTGCTCAATATCTTCACGGTTTGTTCGTCCGAGGTGTTCTTATACTGCACTTCTGTAGAGatATCGGAAAAGGATGGTCTTCCCAGTCTGCTGTGTCAGTCGTGTTCGGATCTCATAAATAaactgtattattttaaacaattagtTATCAGATCTGATGTAACTCTGAGGCATTACGGTCAAATTCAggttAAAAAAGAAACCAATCAAGACTCGGTTTCTGAATCGTCGGGTTTGCCGACAGACGATTTCGATAGACTCCAAGAAAGTACGGCTTCTAATTCAGAATTGCCTATTAAATCTCCTGTATCGTTACCAGATTTGCAATCGGATATTGAAGACGCTTTTAACAATGAAGacgaaattaaacataaaaaatcaaaaaaATCAGAAAAGTCGtctaaaaagaagaaaaaaaaggtgaaagagaaaaaagttaaattggCTAGACTTCTCAAATGTGCGAAATGCAAAAAATCGttccaaaaatatgaaaaattagaagCACACATGCGATTGCATTTCGGACTGCagCCCGACATAAGGTGCAAGGAATGTAACAAGGAGTTCACAAGCTTTAATAATCTGTACAGTCATATGCGTGTCCACACGGGCATTCGTAAATACAAGTGTAAAACATGCAATAAAGCTTTTGCTTATCTGAACGTGCTCAAGAACCACGAGAAGGCGCACGCGGGAATCAAGAAATACGTTTGCCACGAGTGCGGCGCTAAATTCGTTCAACCCACCAACTTGAAGGTATTAGAATTCAACATTGAACgcGAAAGGCCGTACGGTTGCGACTTCTGTCCTATGAAATTTATGGCGAAGAAGGATCTGAAGAACCATCGGATGACCCACACCGGCGAAAGACCACACAAATGTCACGTGTGCAGTCAAGGTTTTATCCAAAAATGCGCACTGAACCGCCATATGAAGACTCATCGAGCGACTTATTATCCACCTCCTCAACAGCCTCCTATAGTGCCGCAGATGCACGATTATATCGCTCATCATCCGCagtga
Protein Sequence: MQQGQQLSSVCRACLTNDGRLLNIFTVCSSEVFLYCTSVEISEKDGLPSLLCQSCSDLINKLYYFKQLVIRSDVTLRHYGQIQVKKETNQDSVSESSGLPTDDFDRLQESTASNSELPIKSPVSLPDLQSDIEDAFNNEDEIKHKKSKKSEKSSKKKKKKVKEKKVKLARLLKCAKCKKSFQKYEKLEAHMRLHFGLQPDIRCKECNKEFTSFNNLYSHMRVHTGIRKYKCKTCNKAFAYLNVLKNHEKAHAGIKKYVCHECGAKFVQPTNLKVLEFNIERERPYGCDFCPMKFMAKKDLKNHRMTHTGERPHKCHVCSQGFIQKCALNRHMKTHRATYYPPPQQPPIVPQMHDYIAHHPQ

Sequence clustering based on sequence similarity using MMseqs2