Basic Information

Gene Symbol
-
Assembly
GCA_009617725.1
Location
VTON01000007.1:4226835-4229450[+]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 12 0.055 4 8.1 2.8 1 23 149 172 149 172 0.96
2 12 0.24 18 6.0 0.8 1 23 197 219 197 219 0.90
3 12 0.18 13 6.5 3.5 2 23 285 306 285 306 0.94
4 12 3.5e-05 0.0026 18.1 0.9 2 23 318 339 317 339 0.97
5 12 0.0035 0.26 11.8 4.2 1 23 345 367 345 367 0.98
6 12 3.2e-06 0.00024 21.4 0.7 1 23 373 395 373 395 0.98
7 12 4.2e-07 3.1e-05 24.2 5.1 1 23 401 423 401 423 0.99
8 12 0.033 2.5 8.7 4.0 1 23 429 451 429 451 0.82
9 12 8.9e-08 6.5e-06 26.3 0.2 1 23 457 479 457 479 0.98
10 12 0.00031 0.023 15.1 6.3 1 23 485 507 485 507 0.98
11 12 3.3e-05 0.0024 18.2 0.8 1 23 513 535 513 535 0.98
12 12 0.00045 0.033 14.6 5.1 1 23 541 563 541 563 0.97

Sequence Information

Coding Sequence
ATGGCGGCGAAGGGTACGCCTTTGTACTGGAGTCAACGTTTCGTTCGGCTCGTCGCTCTGTTCGGAATGCTGGAGACGGCTCGTTGCTGCAGCACAATTTCGACGACTTTGTCGAGCTTCTGCCCGGACGCTACGAACTACGGTAGgaccAAGAACATGATAAAAGAAGAGAATTTAAGCTGTGTGAAAAATGAGCTGTTCAATCAAGGGTCTAAAGGTAGTTGGGATGCATTCGAGACGGATGATCCGTTTAATTTCAGCAATGAAATATGTCATCAAAACGAAGGGTGttatgatttcaaaaatattgattctgAAAGTATCGCGACATATACTGAGAATATGCTAGAAAGAACACCAGATAATAGAATTATGCATTTCACACCAGAAACGGCCACAAATTTTGGAATTCCtgtatcaaatgaaaatgaaaacagtaaatatttcaagtgTGAATtgtgttatgattttttcactGAAAACCACTTGTtggaaaatcatttgaaagaaaaacatttcgatAGTGCACCACaacaGATGAAAATTGAAGTACCACTCTCTGTCGATCAGAAACATGACAAATTGATATACAGATGTTTAAAATGTAACGAAGAATTtacattattgaatatatttaaagatcATCTTCAAGAACATCTAGAGAATACTAGCCAATTTTTGAACACAGTTAACGATTTTCAAGAAGTATATAATCATAGTGAAGAATTAACAAATATGGATAACCTCGCATTATTGCCacaatctaataattttattatccaaCCGTTTGACAAAAGTGAATCATCAAAAActTCTTTTGAGTctactgaaattaaaaagcttTCATTGGCTCGATGTAAATTCTGCTCAAAAAGCATTCACCAATCATTGCTTCTTAGgcatatttcacaatttcacaatggaaaaactgtTATGCACAAAAATTCCTTGAGATGTCCTAAATGTGggaaacaattcaaattgtcCAACCGGTTAGATGCACACATGAGGCAACATTATGGATTAAAAcctTTTGTTTGTCAGATATGTTTTAAAGAATTGTCCAAtcataaaacatacaaaatgcaCATGAATCGACACAACggcaagaaaaaatatgtctGTAACGTTTGTgataaaacatttacatatcCCACAGTCTTGAAAATGCATAAAAGAATTCATCTtggtatcaaaaaatttacttgCAAAGAATGTAATACAAGTTTTACCCAGTCTAACCATTTGAAGaaCCACATCAAGACTCACTCTAACGAGCGATCTTTTAAATGTGTTCAATGCGATAAATCTTTCAAAACTAAAGCTATTTTAAAATGCCACACGGACAGGCACAAAGGATTACGCAATTATGTTTGTTCTATTTGTGGTAAAAGCTTCAAAACGAGTGGTGAATTGAATGTCCATGCGCAGTCacatttaaacaataaaactttttcatgcACATTGTGCAAGAAATCTTTCAAAACACATAGGCAGCTTTCGGAACATAATCGACGACACACAGGTGAAAGACCCTTCAAGTGCGATATATGTTCGAAAGACTTCATGACGTCCCAAGTGCTGAAACGTCATCTCATGGTGCATACTGGGGCGAAACCCCACGTTTGTCATTTGTGCAATAacacatatacacaaaaatatatgttgaaTAAGCATTTAGAATCTCACAAGCAGGCTCTCGAAGGGATTCGTTTCGAAGCCTGA
Protein Sequence
MAAKGTPLYWSQRFVRLVALFGMLETARCCSTISTTLSSFCPDATNYGRTKNMIKEENLSCVKNELFNQGSKGSWDAFETDDPFNFSNEICHQNEGCYDFKNIDSESIATYTENMLERTPDNRIMHFTPETATNFGIPVSNENENSKYFKCELCYDFFTENHLLENHLKEKHFDSAPQQMKIEVPLSVDQKHDKLIYRCLKCNEEFTLLNIFKDHLQEHLENTSQFLNTVNDFQEVYNHSEELTNMDNLALLPQSNNFIIQPFDKSESSKTSFESTEIKKLSLARCKFCSKSIHQSLLLRHISQFHNGKTVMHKNSLRCPKCGKQFKLSNRLDAHMRQHYGLKPFVCQICFKELSNHKTYKMHMNRHNGKKKYVCNVCDKTFTYPTVLKMHKRIHLGIKKFTCKECNTSFTQSNHLKNHIKTHSNERSFKCVQCDKSFKTKAILKCHTDRHKGLRNYVCSICGKSFKTSGELNVHAQSHLNNKTFSCTLCKKSFKTHRQLSEHNRRHTGERPFKCDICSKDFMTSQVLKRHLMVHTGAKPHVCHLCNNTYTQKYMLNKHLESHKQALEGIRFEA

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
-