Basic Information

Insect: Hybos culiciformis
Gene Symbol: topi
Assembly: GCA_964007475.1
Location: OZ023273.1:57760908-57765873[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 12 2.6 1.9e+02 3.4 3.5 2 23 62 84 62 84 0.94

2 12 2.2e-05 0.0016 19.3 6.8 2 23 96 118 95 118 0.93

3 12 4.9e-06 0.00036 21.4 2.0 3 23 226 246 225 246 0.99

4 12 2.2e-06 0.00016 22.5 0.4 1 23 252 277 252 277 0.94

5 12 0.00024 0.017 16.1 3.4 1 20 286 305 286 311 0.95

6 12 0.14 10 7.4 0.3 2 23 319 341 318 341 0.92

7 12 0.017 1.2 10.3 3.4 2 23 347 369 346 369 0.96

8 12 4.7e-06 0.00034 21.5 0.6 1 23 376 398 376 398 0.96

9 12 2.4e-06 0.00017 22.4 1.4 1 23 404 426 404 426 0.98

10 12 3.3e-07 2.4e-05 25.1 2.2 1 23 432 454 432 454 0.97

11 12 1.6e-07 1.2e-05 26.1 1.8 1 23 460 482 460 482 0.99

12 12 6.7e-06 0.00049 21.0 1.8 1 23 487 510 487 510 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	12	2.6	1.9e+02	3.4	3.5	2	23	62	84	62	84	0.94
2	12	2.2e-05	0.0016	19.3	6.8	2	23	96	118	95	118	0.93
3	12	4.9e-06	0.00036	21.4	2.0	3	23	226	246	225	246	0.99
4	12	2.2e-06	0.00016	22.5	0.4	1	23	252	277	252	277	0.94
5	12	0.00024	0.017	16.1	3.4	1	20	286	305	286	311	0.95
6	12	0.14	10	7.4	0.3	2	23	319	341	318	341	0.92
7	12	0.017	1.2	10.3	3.4	2	23	347	369	346	369	0.96
8	12	4.7e-06	0.00034	21.5	0.6	1	23	376	398	376	398	0.96
9	12	2.4e-06	0.00017	22.4	1.4	1	23	404	426	404	426	0.98
10	12	3.3e-07	2.4e-05	25.1	2.2	1	23	432	454	432	454	0.97
11	12	1.6e-07	1.2e-05	26.1	1.8	1	23	460	482	460	482	0.99
12	12	6.7e-06	0.00049	21.0	1.8	1	23	487	510	487	510	0.98

Sequence Information

Coding Sequence: atgGAGACTGAGAATAAAGAACtcgattatgaaaatatttgtcaCACATGTTTAAAGAATGCAGAAGATCTTCTTAATGTTGAGATTGAGAGTGGTGGTGACGGTGATGATATTGCATCTATGTTACGCACTCTTTCTGGCTATGAGAGTCACAGACATTTGGTGCATCAGAATGAACCAAATGAATGCAGATTCTGCCACAAAATATTTGGTCCATTAAATAGATTAAGGTACCATTTAATTAGTTGTCATTCTGAAAATGGATACCCTGCACCGTCACATTGCTCTTGCACACATTGTGGAAAGCAATTCGCTAGAAGTGATCATTTAAGAcgacatttaaattttgtacataatatagaaACGGTGCAATTGAGCCATAACAAAGTAGAGAATATCGActtGAAGGAAGAAATAGAAGAAGAAACATTCAATGAGAGTGCCAATGATAATGAATTGAGTGAAGACGATGTGaagaatgaaaatttgaaaactgaTAACTTAGCTGATAATTTGTTTGTAGATGTAAAACACGttgattcttttttattatactctACAAAAACTATTAAAGAAAAcgttaataatgataaaattgagataactaaaaaaaaatctaaacgaTCCgtctttaaacaaaattttaaaagagaTCCAGAAAATGGGAAGCCACTATGTGATACATGtggaaaaacattttcaatcgCCAGTCATTTATATCGTCATCAACAAACTCACACTAATCCTTCCCCATTCAGTTGTTTAGTTGGAGATTGTCAAAAAAGTTTCAgtcgaaaacaaaatttaaataatcacaTGGCAAGTGCTCATCCAGGGTCAATAGATTTGGAGCCTTTTGAATGTtctttatgtttcaaaaaatttactagaaaaGATCATGTAAAGCGACATTTAGAAATTTGTGGAAAAACTAAAGTGAGGGAGAAAACCCAAACATGCATGATATGTAATAAAACGTTTTTAAGTGAAGCAATTTTGGCAAGGCATGTTAGATCTACTCATGAAAGAACTGAGTGGAAATGTAAATATTGCAAAAtgtCTTTTGCAAGCGATGATGagaagaaaattcatttaaaaaaatgccATCCAACTCAGTTAAAACAGTATTTATGCAATTTGTGTGGAATGGGTTTCATTCGTAATGACTATTTACGGAACCATTTGAGACGGCATACAgGTGAGAAACCATTCAAATGTAAATATTGTGATAAAGGATTTCCAAGATCAACCGACTTAAATGTTCATGAAAAATATCACACTGGTGAAAAAAATCATGTATGTGATAcctgtggaaaaaaatttaccCGATCATATAATTTAGTTATTCACAGAAGAGTTCATACAGGTGAAAAACCTTACAAGTGTCCACATTGCCCGAAGAGATTTGCTCAAAGTAATGATATGAAGGCCCATATTCGCAGACACACTGGAGAAAGATTTCGTTGTGAAATTTGTAATGAAGGATTTATTCAACTTTATCATTTAACTCAGCATAAAAGAACGGTGCACAAGATATATGTGCCCTCTCATATAAAAcgattagaaaaatttttgactCCTGCAGAACCAaatgaaaagtttattaaaattgaaatgttgGAGGACGCAAAATTAAGCTCAAAAGTGATGGATTCCAGTGACTtttaa
Protein Sequence: METENKELDYENICHTCLKNAEDLLNVEIESGGDGDDIASMLRTLSGYESHRHLVHQNEPNECRFCHKIFGPLNRLRYHLISCHSENGYPAPSHCSCTHCGKQFARSDHLRRHLNFVHNIETVQLSHNKVENIDLKEEIEEETFNESANDNELSEDDVKNENLKTDNLADNLFVDVKHVDSFLLYSTKTIKENVNNDKIEITKKKSKRSVFKQNFKRDPENGKPLCDTCGKTFSIASHLYRHQQTHTNPSPFSCLVGDCQKSFSRKQNLNNHMASAHPGSIDLEPFECSLCFKKFTRKDHVKRHLEICGKTKVREKTQTCMICNKTFLSEAILARHVRSTHERTEWKCKYCKMSFASDDEKKIHLKKCHPTQLKQYLCNLCGMGFIRNDYLRNHLRRHTGEKPFKCKYCDKGFPRSTDLNVHEKYHTGEKNHVCDTCGKKFTRSYNLVIHRRVHTGEKPYKCPHCPKRFAQSNDMKAHIRRHTGERFRCEICNEGFIQLYHLTQHKRTVHKIYVPSHIKRLEKFLTPAEPNEKFIKIEMLEDAKLSSKVMDSSDF

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -