Basic Information

Insect: Horisme vitalbata
Gene Symbol: ZEB2
Assembly: GCA_951804965.1
Location: OX638109.1:8915020-8917197[+]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 21 1.3e-05 0.00099 20.3 2.8 3 23 126 146 125 146 0.98

2 21 3.5e-07 2.7e-05 25.2 1.2 1 23 151 173 151 173 0.97

3 21 5.1e-06 0.0004 21.5 2.0 1 23 179 201 179 201 0.99

4 21 2.6e-05 0.002 19.3 1.0 1 23 209 231 209 231 0.99

5 21 9.2e-07 7.2e-05 23.9 1.5 1 23 243 265 243 265 0.98

6 21 0.0031 0.24 12.8 2.5 1 23 270 292 270 292 0.99

7 21 6.6e-05 0.0052 18.0 0.4 1 23 296 320 296 320 0.96

8 21 4.8e-05 0.0037 18.5 1.3 1 23 326 348 326 348 0.97

9 21 0.005 0.39 12.1 2.9 1 23 354 376 354 376 0.92

10 21 0.00027 0.021 16.1 2.5 3 23 384 404 382 404 0.98

11 21 4.8e-05 0.0038 18.5 3.1 1 23 410 434 410 434 0.96

12 21 1.1e-05 0.00087 20.5 0.3 1 23 440 462 440 462 0.97

13 21 1.6e-05 0.0012 20.0 4.2 1 23 468 490 468 490 0.98

14 21 1.7e-05 0.0013 19.9 5.3 1 23 496 518 496 518 0.97

15 21 0.00071 0.056 14.8 0.2 1 23 524 546 524 546 0.96

16 21 1.3e-05 0.001 20.2 1.1 1 23 550 572 550 572 0.98

17 21 3.9e-06 0.0003 21.9 1.1 1 23 578 602 578 602 0.97

18 21 1.8e-05 0.0014 19.8 1.2 1 23 608 630 608 630 0.97

19 21 3.7e-08 2.9e-06 28.3 0.6 1 23 636 658 636 658 0.98

20 21 0.0015 0.12 13.8 0.0 1 23 664 686 664 686 0.97

21 21 1.2e-06 9.1e-05 23.6 7.7 1 23 693 715 693 715 0.99

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	21	1.3e-05	0.00099	20.3	2.8	3	23	126	146	125	146	0.98
2	21	3.5e-07	2.7e-05	25.2	1.2	1	23	151	173	151	173	0.97
3	21	5.1e-06	0.0004	21.5	2.0	1	23	179	201	179	201	0.99
4	21	2.6e-05	0.002	19.3	1.0	1	23	209	231	209	231	0.99
5	21	9.2e-07	7.2e-05	23.9	1.5	1	23	243	265	243	265	0.98
6	21	0.0031	0.24	12.8	2.5	1	23	270	292	270	292	0.99
7	21	6.6e-05	0.0052	18.0	0.4	1	23	296	320	296	320	0.96
8	21	4.8e-05	0.0037	18.5	1.3	1	23	326	348	326	348	0.97
9	21	0.005	0.39	12.1	2.9	1	23	354	376	354	376	0.92
10	21	0.00027	0.021	16.1	2.5	3	23	384	404	382	404	0.98
11	21	4.8e-05	0.0038	18.5	3.1	1	23	410	434	410	434	0.96
12	21	1.1e-05	0.00087	20.5	0.3	1	23	440	462	440	462	0.97
13	21	1.6e-05	0.0012	20.0	4.2	1	23	468	490	468	490	0.98
14	21	1.7e-05	0.0013	19.9	5.3	1	23	496	518	496	518	0.97
15	21	0.00071	0.056	14.8	0.2	1	23	524	546	524	546	0.96
16	21	1.3e-05	0.001	20.2	1.1	1	23	550	572	550	572	0.98
17	21	3.9e-06	0.0003	21.9	1.1	1	23	578	602	578	602	0.97
18	21	1.8e-05	0.0014	19.8	1.2	1	23	608	630	608	630	0.97
19	21	3.7e-08	2.9e-06	28.3	0.6	1	23	636	658	636	658	0.98
20	21	0.0015	0.12	13.8	0.0	1	23	664	686	664	686	0.97
21	21	1.2e-06	9.1e-05	23.6	7.7	1	23	693	715	693	715	0.99

Sequence Information

Coding Sequence: ATGCTGAATATCGAGTTATCTCATAATCTATCCATCAGCGAACCACAATCCATGTTCACCATATACATGAGTGACGATTCAGCCGTCAAACTCGAGCCAATCACGCTAAAGGAGGAAACTTACCCTCAGGGGGGAATCTTCCAGATCACATTCACGGACGATGCTGAGCCTGAACAAATACTGATCAGTGAACCAATACTGATAAGTGAACCAATACTTATCAAAGACGAAGATATTCCAAGCTCATGTATCGAAGAACTTCCAACCTCCAGTATTGAAGAACTTCCGATTCAATCTACGTTACATAGCGATACAAGTTTTGAACTTCCAACTACATTAAATAGCGACGAAGACACCCAAACGTCTACCGAGCACTGTGATAAATGCGATAAACCATTCGCAAACAAATACACGTATGAGCAACATATGAAAACCCATAGAGGGAACATCTACTCTTGCAATCAATGCCCTAAAACATTTAAACGGAAAAAAAATCTGGCGAAACACGTGATCGTACACACTGAAGACAGTTCTTACACCTGTTCCATATGCAGCGAGACATTCGACCAgcagagcacattccaaaaacaTTTATCGACCCATACCAAAGATAAATCCGATACCTACAGATGTAACTTATGCAGTAAGACGGCAAACAATCTCTACAACCTACAGATTCACATGTCGACCCATAGCCGGAAGAAAACCGGAAACGTATCGGATGAGTTCGTGTGCGATATTTGCGGGAAAAGTCTCAACAACCAACACAATCTGCAGAAGCATAGAGCGACGCACGCCGTCGACTCATACACATGCGAATTTTGTTCAAAGAACTATCTGAACCGCGATTCCTGGAGAAAGCATCTCAGAACTCACTCCGCGCAACATGTTTGCTCTCACGCTGGCTGCGGGAAGGCATTCCCTCAGAGGAATCAGCTGATAGTCCACGCCAGAGTCCACACGGGAGAGAGACCTTTCGCCTGCGACACTTGCGACAAAACATACACCAAAATGGAGTCCTTAAAAATCCACCAGAAGAGCCACACGCGAGAGAAACCACACAAGTGTATCTCCTGCAACAAATCGTTCAATTTGAAAAGCAGTCTATTGGAGCATATCAAGAGCCACGCGGAGACGCAGTCGTTTGGCTGCGCGCATTGCGATAGGACGTTCCCGCTCCTCGCGCATCTCAAGCGACACATAACGACACACGACACGGCGAGACGACACACATGCGACCAGCCCGGCTGCGGGAAACAATTCGTGCGGAAATATCATCTGAAGGAACACTCCCGAGTCCACACCGGAGAGAGACCGTACGCGTGCGGCGAATGCGAGAAAACTTTCATCAAGTCGGAATCGTTGCGAGCACATCGCAAGATACACTCCGGAGAAAAACCGCACAAATGTAGCACTTGCAGCAAAGCGTTCTACAGAAAGCCCAATCTATTGAAACACATGACGACGCACGAGGAGAAGGACTCGTTCGACTGCGAACATTGCAGCAAGACTTTCTCTCACCCAGTGCATCTAGAGACGCATCTGCTGACTCACTCGGCGGCGAAATCGCACGCATGTGCGCTCTGCGATGCGACTTTTGCCGCGCGGAGCAGTCTCTCGGCGCATCTCAAGACTCACGAATACAAATTCACGTGCGACAGATGCGCTAAAAGCTTCCGCGATAAAGGAACCTTGCAGAGCCATATAAAACTACACGACGGCGTAAAACCGTACGTGTGCGAGCATCCCGGCTGCGGGAAAGCGTTCGCGAGGCGATATCACCTGAAGGAGCACGCCAGAGTCCACACCGGGGAGAAACCGTTCGTTTGTAACGAGTGCGGGAAAACGTACACTCAGAGCAGTGCGTTGTTCTTCCACCAGCGACTGCACACGGGGGAGAGACCGTACGTGTGTGATATATGCGGGAGAACGTTCACAGATAAGTATGGGTTACAGAAACACACGCGTGTTCATACGGGAGAGAAACCGTACGCGTGTGAGGAGTGCGACGTGCGGTTTGCGTACGCCGGCGCGCTGAGAGACCACAGCGCGACGCACGCCGCCGGAGAAAAACCGTACTCGTGTGACAGATGTTTTAAATCTTTCTGCAGAAAGAGTAACCTTAAGAAACATATGAAGACGCATCTAAGAGAGAAACAGTTCTTTAAAAGTCCGTAA
Protein Sequence: MLNIELSHNLSISEPQSMFTIYMSDDSAVKLEPITLKEETYPQGGIFQITFTDDAEPEQILISEPILISEPILIKDEDIPSSCIEELPTSSIEELPIQSTLHSDTSFELPTTLNSDEDTQTSTEHCDKCDKPFANKYTYEQHMKTHRGNIYSCNQCPKTFKRKKNLAKHVIVHTEDSSYTCSICSETFDQQSTFQKHLSTHTKDKSDTYRCNLCSKTANNLYNLQIHMSTHSRKKTGNVSDEFVCDICGKSLNNQHNLQKHRATHAVDSYTCEFCSKNYLNRDSWRKHLRTHSAQHVCSHAGCGKAFPQRNQLIVHARVHTGERPFACDTCDKTYTKMESLKIHQKSHTREKPHKCISCNKSFNLKSSLLEHIKSHAETQSFGCAHCDRTFPLLAHLKRHITTHDTARRHTCDQPGCGKQFVRKYHLKEHSRVHTGERPYACGECEKTFIKSESLRAHRKIHSGEKPHKCSTCSKAFYRKPNLLKHMTTHEEKDSFDCEHCSKTFSHPVHLETHLLTHSAAKSHACALCDATFAARSSLSAHLKTHEYKFTCDRCAKSFRDKGTLQSHIKLHDGVKPYVCEHPGCGKAFARRYHLKEHARVHTGEKPFVCNECGKTYTQSSALFFHQRLHTGERPYVCDICGRTFTDKYGLQKHTRVHTGEKPYACEECDVRFAYAGALRDHSATHAAGEKPYSCDRCFKSFCRKSNLKKHMKTHLREKQFFKSP

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -