Basic Information

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 5 2.8e-05 0.002 19.1 0.6 2 23 105 129 104 129 0.96

2 5 5.9e-05 0.0041 18.1 0.4 1 23 136 158 136 158 0.97

3 5 0.00071 0.049 14.6 0.1 2 23 164 185 163 185 0.97

4 5 0.0011 0.075 14.1 1.8 1 23 191 214 191 214 0.94

5 5 3.9e-06 0.00027 21.7 1.3 2 23 220 241 219 241 0.97

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	5	2.8e-05	0.002	19.1	0.6	2	23	105	129	104	129	0.96
2	5	5.9e-05	0.0041	18.1	0.4	1	23	136	158	136	158	0.97
3	5	0.00071	0.049	14.6	0.1	2	23	164	185	163	185	0.97
4	5	0.0011	0.075	14.1	1.8	1	23	191	214	191	214	0.94
5	5	3.9e-06	0.00027	21.7	1.3	2	23	220	241	219	241	0.97

Coding Sequence: ATGGAgcaagttataaatatattatgtgatGACATTGAAGAACAAAGCAACAGTGCTAATTTTATTACGGAAACCACTGATccTTTGCAAGAATATGGCGCTGGAGATACATTAAATACAAAGCCAAGATTCTACAGAATCAACAGTATTGTGTTTGCAGAACCTTTGAAAAGCACTTCAAATGAAGAAAACTTATCAAAAGAAAGTAAAGAAAACAATGAAATAGTGATCATAGACAACCTAATAGTATGTAAGGAGAGCggcaagaaatataaaaaatatcactTCAAAATTGAAGAGAGTTCTCCGACGAGATGTCCTCAGCTCAACTGCCTTCGTACATTCTCAACTAAAAAACTTCTCATAGCCCATATACGAAGAGTCCACTGCGCGGACCGCAAGAAGTACATCTGTGAGCAATGTGGCCGTGGGTTCCCTGAACTTCACATGTTACGCAGACATGCAGACACGCACAGTGAGAAGACAGTGGAATGTCCTGTGTGTGGTGTGAAGCTGAGGTTGCGGACCAGTCTGGCAACCCATCTCCGCTCTCACTCCAACCTGCGACCTCACGAATGCGGTGTCTGCAAGAAGACATTCACCAGAGGCTCGAGCAAGGCAACACACATCAAGTTTGTGCACAGAGAGGGATTGTTGGAATGCAATGAGTGTGACAAAAGGTTCTCATCTCGAAAACAGTGGAGTCTACACATGACGACCCACAAACAAAAGAAACCTGACTGA
Protein Sequence: MEQVINILCDDIEEQSNSANFITETTDPLQEYGAGDTLNTKPRFYRINSIVFAEPLKSTSNEENLSKESKENNEIVIIDNLIVCKESGKKYKKYHFKIEESSPTRCPQLNCLRTFSTKKLLIAHIRRVHCADRKKYICEQCGRGFPELHMLRRHADTHSEKTVECPVCGVKLRLRTSLATHLRSHSNLRPHECGVCKKTFTRGSSKATHIKFVHREGLLECNECDKRFSSRKQWSLHMTTHKQKKPD

Sequence clustering based on sequence similarity using MMseqs2