Basic Information

Insect: Hololepta plana
Gene Symbol: topi
Assembly: GCA_963695495.1
Location: OY968833.1:12463692-12465735[-]

Transcription Factor Domain

TF Family: zf-C2H2
Domain: zf-C2H2 domain
PFAM: PF00096
TF Group: Zinc-Coordinating Group
Description: The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out: # of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc

1 14 0.0011 0.093 12.9 1.1 2 21 20 39 19 40 0.94

2 14 1.6e-05 0.0013 18.7 2.0 1 23 65 87 65 87 0.98

3 14 0.02 1.7 8.9 3.9 3 23 95 115 94 115 0.95

4 14 0.94 79 3.7 0.1 2 19 134 151 133 153 0.87

5 14 5e-06 0.00042 20.3 0.6 2 23 192 213 191 213 0.97

6 14 0.084 7.1 7.0 0.0 1 21 219 239 219 240 0.89

7 14 0.0047 0.4 10.9 3.1 2 22 256 276 255 279 0.88

8 14 0.25 21 5.5 0.0 1 23 391 414 391 414 0.95

9 14 0.01 0.86 9.9 0.3 1 23 418 440 418 440 0.97

10 14 5.2e-06 0.00044 20.2 5.4 1 23 446 468 446 468 0.98

11 14 0.01 0.87 9.9 0.1 1 23 474 499 474 499 0.96

12 14 0.18 15 6.0 2.5 1 23 505 527 505 527 0.86

13 14 6.9e-06 0.00058 19.9 0.5 3 23 535 555 533 555 0.98

14 14 1.7e-06 0.00014 21.8 0.7 1 23 561 584 561 584 0.98

#	of	c-Evalue	i-Evalue	score	bias	hmm coord from	hmm coord to	ali coord from	ali coord to	env coord from	env coord to	acc
1	14	0.0011	0.093	12.9	1.1	2	21	20	39	19	40	0.94
2	14	1.6e-05	0.0013	18.7	2.0	1	23	65	87	65	87	0.98
3	14	0.02	1.7	8.9	3.9	3	23	95	115	94	115	0.95
4	14	0.94	79	3.7	0.1	2	19	134	151	133	153	0.87
5	14	5e-06	0.00042	20.3	0.6	2	23	192	213	191	213	0.97
6	14	0.084	7.1	7.0	0.0	1	21	219	239	219	240	0.89
7	14	0.0047	0.4	10.9	3.1	2	22	256	276	255	279	0.88
8	14	0.25	21	5.5	0.0	1	23	391	414	391	414	0.95
9	14	0.01	0.86	9.9	0.3	1	23	418	440	418	440	0.97
10	14	5.2e-06	0.00044	20.2	5.4	1	23	446	468	446	468	0.98
11	14	0.01	0.87	9.9	0.1	1	23	474	499	474	499	0.96
12	14	0.18	15	6.0	2.5	1	23	505	527	505	527	0.86
13	14	6.9e-06	0.00058	19.9	0.5	3	23	535	555	533	555	0.98
14	14	1.7e-06	0.00014	21.8	0.7	1	23	561	584	561	584	0.98

Sequence Information

Coding Sequence: ATGGCCGTGGTGAAGCAATTGAAGAAACCCGAAAGTACCCCGTCTAAAGGTACGATAGTCTGCCAGAATTGCGAGATGAACTTCCCGACGAAATACCAATACCAACGGCACCAGTGCGAATTCAATGCGGCCAAAGTCGTGCTAAAAGCGAACGCCGACATGAAGGACGTCGATAAGGGGATGCGAATGAAGTACGAGTGTTCGACGTGCAGCAAACAGTTTGTCAGTAAGAACAATTTGGATCGGCATCAGACTAGCCACGACGAGAGTAACGTCAACATTTGCGAACACTGTCAGAAGCATTTCGTCAGCGAGAACCGTTTGCGTATACACAAGGAGAATCATTGCAAGAAGGCCGGCGACATATCAAAATTTTATAGGAGCGACGTGGCCGTGTGGCAGTGCATCAAGTGCAATCGCGTTTTCGCAACCGTCACGTCCGCGAACAAACACGCGGCGAACTGCAACGAATTGGCGATCGACGACAACGTGCGACAATCGAATCGCAACGATTCGGACGCGTTGAACGGGCCGTTGAAATCCGTAGTGAAGGTGCTAACCGAATTACTGTTGCAGTGCGAGTTTTGCAATCGAACGTACGCCGACAAAGCGTTACTGTTGCAGCACCAGCGAACGCACACGACGACGATCAATTACGTGTGCGTGCGGTGCGACGAAACGTTCGATTCGTACGTGACGGCAGCGAAACACTGGCTCACCAAATGCTCGGACGAGGAGAATCTCTTCTATCTACCGAAACTCACGTACTGCGAATACTGCGATCGCACGTTCAAGTCGCACGACGTCCTCTACACGCACAAGATCAAGAAGAAGCATTACACGCCGAAAGCGCAATCGACGAACGGACCGGTGGCGGCAGCAGAAGACGGGACGAAGGACAACAAAAGCTCGATCGTGAAACTGATCGAGGACACGTTGATGGCGATCAACGTGCCGAATCTGACGCCGAACGAGCCGGCGAACGTGAAGAAGGAAGTCGAGATGCAACCGACCACCGAAAACGTAATAGACATAACCGTCGATCGCAAAGACGAGGAGATGCCGCCgccggagaagaagaagaaacgcggGCGCAAGAGTAAACAATCGAAACAGCAATCGATTGGCAAGAACAAGAGGATTTCGGCGACGGCCGAACCGGGATATAAGTATCAATGCGAGCGGTGCATCAAAGAGTTCGATGGGATCGCGGATTTGGAACTGCATCGCGAAATTGAGCATCCGACTAATTTCAAGTGCGACGAATGCTCGCAAgtTGTCCACAGTGCGAAAGCTTTGCTCATACACAGTCGCGCCCATCAAAGCTTGAAACCATACGTCTGCGAGATATGCAAGAGATGTTACTCGCAGACCTCACATTTATGGCAACACATGCGGTTTCATCAAGGTATAAAACCGTTTGCTTGTCCTCATGCCGGTTGCGAGGCCCGTTACACGATACGTCCGGACCTAAAAGATCATATCCGCAAAGTACACACGCGCGAGAGACCGTTCAAGTGTGCCGTTTGCAATAAGTGCTTCTTAACCGGATCGGTTTATTATCAACACCGGTTGATACATACGAATGATAGAAGATACGGTTGCGATATATGCCAGAAACGTTTCTTTCGCGCTGACGCCCTCAACAATCACCGTCGTATACATACGGACGAACGGCCGTATCCGTGCGAGATTTGCGGCCGACAGTTTAGACAGAAGGGCGATAGGAACAAACACGTCCGCACGCAACATCCTTCGTCGTGA
Protein Sequence: MAVVKQLKKPESTPSKGTIVCQNCEMNFPTKYQYQRHQCEFNAAKVVLKANADMKDVDKGMRMKYECSTCSKQFVSKNNLDRHQTSHDESNVNICEHCQKHFVSENRLRIHKENHCKKAGDISKFYRSDVAVWQCIKCNRVFATVTSANKHAANCNELAIDDNVRQSNRNDSDALNGPLKSVVKVLTELLLQCEFCNRTYADKALLLQHQRTHTTTINYVCVRCDETFDSYVTAAKHWLTKCSDEENLFYLPKLTYCEYCDRTFKSHDVLYTHKIKKKHYTPKAQSTNGPVAAAEDGTKDNKSSIVKLIEDTLMAINVPNLTPNEPANVKKEVEMQPTTENVIDITVDRKDEEMPPPEKKKKRGRKSKQSKQQSIGKNKRISATAEPGYKYQCERCIKEFDGIADLELHREIEHPTNFKCDECSQVVHSAKALLIHSRAHQSLKPYVCEICKRCYSQTSHLWQHMRFHQGIKPFACPHAGCEARYTIRPDLKDHIRKVHTRERPFKCAVCNKCFLTGSVYYQHRLIHTNDRRYGCDICQKRFFRADALNNHRRIHTDERPYPCEICGRQFRQKGDRNKHVRTQHPSS

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity: -
90% Identity: -
80% Identity: -