Basic Information

Gene Symbol
lola
Assembly
GCA_963695495.1
Location
OY968840.1:3116561-3129701[-]

Transcription Factor Domain

TF Family
zf-C2H2
Domain
zf-C2H2 domain
PFAM
PF00096
TF Group
Zinc-Coordinating Group
Description
The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
Hmmscan Out
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc
1 20 9.5e-06 0.0008 19.4 0.8 1 21 67 87 67 88 0.96
2 20 0.028 2.3 8.5 2.7 1 23 96 119 96 119 0.97
3 20 0.0013 0.11 12.7 2.8 1 20 149 168 149 170 0.95
4 20 0.0087 0.73 10.1 0.1 3 21 207 225 205 226 0.92
5 20 0.0019 0.16 12.2 0.7 1 20 234 253 234 255 0.93
6 20 0.32 27 5.2 3.5 1 21 270 290 270 291 0.94
7 20 0.0018 0.15 12.3 3.2 1 21 347 367 347 368 0.94
8 20 4.1e-06 0.00035 20.5 1.0 1 20 386 405 386 407 0.94
9 20 0.0067 0.57 10.4 1.7 1 20 415 434 415 436 0.93
10 20 0.35 30 5.0 3.2 1 21 451 471 451 472 0.93
11 20 0.00018 0.016 15.4 0.2 1 21 480 500 480 501 0.94
12 20 0.00016 0.013 15.6 1.2 1 22 510 531 510 531 0.95
13 20 0.013 1.1 9.5 1.2 1 20 539 558 539 560 0.93
14 20 0.033 2.8 8.3 0.6 1 21 575 595 575 596 0.95
15 20 0.2 17 5.8 2.2 1 20 604 623 604 625 0.90
16 20 2.6e-06 0.00022 21.2 0.2 2 21 635 654 635 655 0.95
17 20 0.011 0.97 9.7 1.4 1 21 663 683 663 684 0.93
18 20 0.0018 0.16 12.2 0.6 1 21 699 719 699 720 0.94
19 20 0.0011 0.089 13.0 0.2 2 21 741 760 740 761 0.94
20 20 8.5e-05 0.0072 16.4 1.4 1 21 769 789 769 790 0.93

Sequence Information

Coding Sequence
ATGGGGAAACCGTTCTCTCGTTTGGTGGACCGCGAAGCGACAAGTGGCGCGAAGCCGTGCAAGAAGAAAGCAACGTCGAACGGACAGCGCAAATCGCTGAACGAATCGTTACGACTGATCGACAACATCGAGAACGTGCAAGGGAACATTTTCCTGCACAACATTCACGACGCGAACGCCACGTCCGAGGAGTTCGTCTACGAGTGCAACGACTGCGGCCGCAGGTACAAGCTGAAGAGCTCGCTGCGGAACCATCGGAAATGGGAGTGCGGCAAGGAGCCGCAGTTCGAGTGCCTCTACTGTTCGTACAAGGCCAAGCAGAAGATGCACATGTTGCGGCACATCGAGCGCATGCACAAGAACATGGAACTGGTGCAGAACGTGCTCGATCTGAACGTCGACTCGTGCGACTACAAGGATCGCCGTTGCGGTAAACCGTTAACGTTCAAGTGCGACACGTGTAATCGTCGGTACGCCAGCAAGAATTCGTTATGGAAACATAAGCACTATTATTGCGGCAAAGAGCCGAAATTCATGCGAGAAAGACGCAACGTCCCGTTGGAAGGTATTGCGGAAACACATACAGGAAGCGATGCCAGCAAAGGGAAGCGTCTAATTTGTCGGGCTTGCAATAAGACATACGAGAATCGCGCTTCTTTAATATCGCACATCAATCTAGACTGCAACAAGCCGAAGAGTTTCGCatgcgatttttgcaatttcacgtCGAGCAGAAGCTACAATCTGAAGGTACACGTGACTCGTTGCAAACGTCTGAATTTAGAGCGTCCTGGTGGACAATCGCAATTCAAATGCGACACTTGCGATCGACGATACGGCTGCAAGAGTTCGTTGGACAATCACAAGCGTTATTATTGCGGCAAAGAGCCGCAATTCATCTGCACAAAATGTGATGCCGGCAACAGGAAGCGTCCGATTAGCGGCAGTTACAAGAAGACAAGCGGGAAGCCCCACTATTTCTTTGCGAAAGGCGATTATTGCGATTACCGATCGACCAGCCTCTATAATCCGTTAAAATTCAAATGCGACACGTGCAATCGACAGTACACCAACAAGAAATCGTTGTACAATCATAAGCAATATTATTGTGGCAAGGAACCGAAATACGTCTGCGCCATCATCCCACGGGAACAGCACGTCTGTAATTATTGCCAGAGATCGTTTACGAACCAGAGCTCTTTATACGCGCACATTAGTCAGGACTGCAACAAACCCAGACGGTTCGCGTGCAATTATTGCAGCTTCAATTCGATCAGAAAACATAATCTGAAGCAGCATTTGGACCGTGGCATGTGCGTGGTTTTCAAACGTCGCCGTCAACCGTTAAACTTCGTATGCGACACGTGCAATCGGCGGTACGCTTGCAAGAGCTCGTTGTACACGCATAAGCAGTACTATTGCGGCAAAGAGCCGCAATTCGTCTGCCCAAAATGCGGTTACCAATCGTATACGAAGGCCAATCTTCAGTCGCACCTCATTAAATGCGCTATCACCAGACTCAAACGGCATGTTTGTAGTTTTTGCAAGATATCATTCAAGAACCGTAACACATTACTCGCGCACATTCGTCGGGACTGCAACAAACCCGGACGGTTTGCGTGCAATTATTGCAGTTTCAATGCGATCAGAAAACATAATCTGAAGCAGCATTTGGACCGTGGCATGTGCGTGGTTTTCAAACGTCGCCGTCAACCGTTAAACTTCGTATGCGACACGTGCAATCGACAGTACGCTTGGAAGGATTCGTTATCGAGACATAAGCGCTATTATTGCGGCAAAGAGCCGCAATTCGTCTGCCCGAAATGTGATCATCAATCGTATACGAAGTCCAATCATCAGTCGCACCTCATTAAATGCACCATCAGCAGACCGAAGCAGCGCGTCTGCAATTATTGCGGGAGGTCATTTAAGAACCGGAAAACTTTGGTCGCGCACATTCGTCTGGGCTGCAACAAACACGGAAGGTTCGCGTGCAAATATTGCAGTTTCAGGTCGATCAGAAAGTATAAGCTGAAGCAGCATCTAGAAAGTGGCATGTGTCCGGATTTCAAACGTCGCCGTCAACCGTTAAGCTTCATGTGCGACACGTGCAGTCGACGGTACGCTTACAAGAGCTCGTTGAACATGCATAAGCAGTATTATTGTGGCAAAGAGCCGCAATTCGTCTGCCCAAAATGTCTCATCAGAAGGAAACGTCTAGTTTGTCGTGGTTGCAATAAGACGTACATGAACCGGTACTCGTTATTATCGCACATTAATCAAGACTGCAACAAACCGAAAAGTTTCGCGTGcgattattgtaatttcacGTCGACCAGAAAATATAATCTGAAGAAGCACTTGGAACGATGCATCTTGCGTCAGATGAAACGGAGGAAATTATTGTTTCGATTGAAATAA
Protein Sequence
MGKPFSRLVDREATSGAKPCKKKATSNGQRKSLNESLRLIDNIENVQGNIFLHNIHDANATSEEFVYECNDCGRRYKLKSSLRNHRKWECGKEPQFECLYCSYKAKQKMHMLRHIERMHKNMELVQNVLDLNVDSCDYKDRRCGKPLTFKCDTCNRRYASKNSLWKHKHYYCGKEPKFMRERRNVPLEGIAETHTGSDASKGKRLICRACNKTYENRASLISHINLDCNKPKSFACDFCNFTSSRSYNLKVHVTRCKRLNLERPGGQSQFKCDTCDRRYGCKSSLDNHKRYYCGKEPQFICTKCDAGNRKRPISGSYKKTSGKPHYFFAKGDYCDYRSTSLYNPLKFKCDTCNRQYTNKKSLYNHKQYYCGKEPKYVCAIIPREQHVCNYCQRSFTNQSSLYAHISQDCNKPRRFACNYCSFNSIRKHNLKQHLDRGMCVVFKRRRQPLNFVCDTCNRRYACKSSLYTHKQYYCGKEPQFVCPKCGYQSYTKANLQSHLIKCAITRLKRHVCSFCKISFKNRNTLLAHIRRDCNKPGRFACNYCSFNAIRKHNLKQHLDRGMCVVFKRRRQPLNFVCDTCNRQYAWKDSLSRHKRYYCGKEPQFVCPKCDHQSYTKSNHQSHLIKCTISRPKQRVCNYCGRSFKNRKTLVAHIRLGCNKHGRFACKYCSFRSIRKYKLKQHLESGMCPDFKRRRQPLSFMCDTCSRRYAYKSSLNMHKQYYCGKEPQFVCPKCLIRRKRLVCRGCNKTYMNRYSLLSHINQDCNKPKSFACDYCNFTSTRKYNLKKHLERCILRQMKRRKLLFRLK

Similar Transcription Factors

Sequence clustering based on sequence similarity using MMseqs2

100% Identity
-
90% Identity
-
80% Identity
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