Hpse021586.1
Basic Information
- Gene Symbol
- ZFY
- Assembly
- GCA_947369225.1
- Location
- OX376312.1:20139985-20154631[+]
Transcription Factor Domain
- TF Family
- zf-C2H2
- Domain
- zf-C2H2 domain
- PFAM
- PF00096
- TF Group
- Zinc-Coordinating Group
- Description
- The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter [1].
- Hmmscan Out
-
# of c-Evalue i-Evalue score bias hmm coord from hmm coord to ali coord from ali coord to env coord from env coord to acc 1 10 1.4 87 4.3 0.3 1 23 389 411 389 411 0.96 2 10 0.00025 0.016 16.0 0.5 3 23 420 440 419 440 0.98 3 10 0.0026 0.16 12.8 0.2 1 23 473 496 473 496 0.91 4 10 0.00072 0.046 14.6 2.2 2 23 504 525 503 525 0.97 5 10 0.8 51 5.0 0.3 2 23 533 554 532 554 0.94 6 10 0.82 53 4.9 3.7 1 22 559 580 559 584 0.92 7 10 0.00033 0.021 15.6 0.2 1 23 589 612 589 612 0.93 8 10 5.3e-05 0.0034 18.1 3.6 1 23 619 642 619 642 0.98 9 10 0.00013 0.0085 16.9 0.2 2 23 652 673 651 673 0.96 10 10 0.0016 0.1 13.5 6.6 1 23 679 702 679 702 0.95
Sequence Information
- Coding Sequence
- ATGGAATCATATTTAAAAACTATAATTTGCGCAACATGTCTTAGCAATGATCGAGAATTATTTCAAGACAAACTTTTGGGACAAATAATGCTGTTGTTTCCGAAATATCTCCGGTTGAACCTGAACGAAGATCGAGTGTGCTGGGAGTGCCGTGCTGTTCTGATGAAACTCTGGAAATTCCACCAACAGGCTGTGAGAGCTCAGCAGCTGATGAATAATATCCTCTTGAATCAAGAGGGTGAACTAACTAATCTATCAAGCTTAGATCAACGTGACAAAATAGCCGTTGTTGATATTCCTTCTAACTTAGTAACAGTTACAAGTGGTCCCGTAGTCACAAACACTAATAATAGAACAATGAACAGTGCAATAGACAACGGGAAATTTTATTTTATGGAAAATGAAGATTTAACTAATACGAGTAGAACTCAGCAAGTTGCAAGTTCAACTAATAATAGTAAAGTTGTGCCCGTTGTAGTTCGTAATGACAAGGATTATATTCAAAGCAATATTGTACCTTCAGAAGGTACTAAAAATGCAGCTGAATGTCAAAATGACAGAATTACCAATCCAAATATCAATAAGGTAGTTCTATATTCTGTGCCAATGGAGGTAAAGATAATTAACGATAACAATAATGAAGACATAGAAAAACTCAACGTAAATGTCAATAAGGTGATGCGAGATCACATGCCTCTGGAGGTAAACAATGATGACTGTAATGATGACGTAGAAAATAGTATAATTAGAAAAACTTATATTGTCAGAAAAAATAAGAATAAAAAGGATATGAATTATAATGATTTAATTAAATTCGTAAATATTTTAAAAGAAAATAAAATCAGATATAGAGATGTTGATGTATTCGATGAAATACCTATAGTAAACATGAGACATATAGAAATAAAAGGACTTAATGAGAATAATGATGATGAATTTGAATCAAACGATAGATCTGAAGGAAACGATGACACAAACAGCCTAGAAGGGGAAAACGAACCGAACACAACCAAACCAACCTACAAGAGAGCAACGGGAAAACGTAGATACAATTGTAAAGACATTAGAGTTTACAGCAATATTATAGAAATCGAAGTGAGTGAGACACAAATGCAAGAGCTACGCATGAAAGACCGAGACAGTGAATATTACTTGAAAGCAAAATTCAAGTGTGAGAAATGTATATTTGGATATGCAGACATAGGATTATATAAAGCACATCTTTATAAACACAAAGAGGGCTATGGACCAGAACTCTGCAGTGTATGCGAGCAGAGATTCAAGGATCCAGCGGCTTTGAACAAACATCACTTGATCCATCTTAGAGCGTTCCAGTGCACCGTGTGTCAACTCTGGAGCCGCTTCGTGCACACCTTGCTGGGGCAGTGCCGCTGTCGACCAACTCCGGACGGCTTGTTCGTTTGCAAAGAATGCCAGGAGCCGTTCAAGACAGCCGAGCAGCGGAGAGTGCACACAGCAGCGACCCACCCGCCTCCCGACGGGAGGGTGCAGTGCCTCAAGTGCCGCAAATACCTCAAGTCTCAAGAATCGCTCAAAAAACACATGTTACGGCATACGCCTGCCGGCCAGATGGTCCAGTGTGAGATCTGCCAAGCCAAAGTGCACATACGGTCTCTTACTGCACATATGGACAAAATACACGAGAGGGGAAGCCACTACTGCAAGCCATGCGACAAGTTCTACAAGTCTAGATTATCGTACATTACACACTTGAAGACTAATTCCAAGCACGTGTCGACACGGTACGAGTGCGACCACTGCAAGCGGACGTTCGCGAGCAAGGCGTACGTCGCGGATCACATTGCGGCGGCGCACCTCTCCAATACCAAGGTTCATCAGTGCAAGTTCTGTGACAAGAAATACCAGCAGGCTATAAGTCTGCGTGTGCACATGAGGACTCGGCACGGGGTGGGGGTCGCGGTCAAAGACAAGGTGTGCTACGTGTGCGGGAAGGCTTTCGCGGATAGCCATGTTCTTCGTGACCACCTGATGATCCACACGGGGGAGAAACCGCACCAGTGTCAGTACTGCGAGTGGAAGTTCGCTCAGAGATCCACTCTGAGGACACACCACAAGTTCAAACACAAGGGGCTGCCTCTAACACCGCCAGTGACACACAAGTGA
- Protein Sequence
- MESYLKTIICATCLSNDRELFQDKLLGQIMLLFPKYLRLNLNEDRVCWECRAVLMKLWKFHQQAVRAQQLMNNILLNQEGELTNLSSLDQRDKIAVVDIPSNLVTVTSGPVVTNTNNRTMNSAIDNGKFYFMENEDLTNTSRTQQVASSTNNSKVVPVVVRNDKDYIQSNIVPSEGTKNAAECQNDRITNPNINKVVLYSVPMEVKIINDNNNEDIEKLNVNVNKVMRDHMPLEVNNDDCNDDVENSIIRKTYIVRKNKNKKDMNYNDLIKFVNILKENKIRYRDVDVFDEIPIVNMRHIEIKGLNENNDDEFESNDRSEGNDDTNSLEGENEPNTTKPTYKRATGKRRYNCKDIRVYSNIIEIEVSETQMQELRMKDRDSEYYLKAKFKCEKCIFGYADIGLYKAHLYKHKEGYGPELCSVCEQRFKDPAALNKHHLIHLRAFQCTVCQLWSRFVHTLLGQCRCRPTPDGLFVCKECQEPFKTAEQRRVHTAATHPPPDGRVQCLKCRKYLKSQESLKKHMLRHTPAGQMVQCEICQAKVHIRSLTAHMDKIHERGSHYCKPCDKFYKSRLSYITHLKTNSKHVSTRYECDHCKRTFASKAYVADHIAAAHLSNTKVHQCKFCDKKYQQAISLRVHMRTRHGVGVAVKDKVCYVCGKAFADSHVLRDHLMIHTGEKPHQCQYCEWKFAQRSTLRTHHKFKHKGLPLTPPVTHK
Similar Transcription Factors
Sequence clustering based on sequence similarity using MMseqs2
- 100% Identity
- iTF_00807111;
- 90% Identity
- -
- 80% Identity
- -